Blood Glucose levels - What, how & when to monitor

NIDUS, BEIJING JUNE 2006

Assessment of glycemic control.

2 handy tools that are commonly used: SMBG / Laboratory blood sugar estimations HbA1c. ? S. fructosamine

The frequency and timing of SMBG/ BS estimations

should be dictated by the particular needs and goals of the patients. Daily SMBG/BS estimations is especially important for patients treated with insulin to monitor, diagnose and prevent asymptomatic hypoglycemia and hyperglycemia. For most patients with type 1 diabetes and pregnant women taking insulin, SMBG is recommended three or more times daily.

In type 2 DM
The optimal frequency and timing of SMBG for patients with type 2 diabetes on oral agent therapy is not known. Patients with type 2 diabetes on insulin typically need to perform SMBG more frequently than those not using insulin. When adding to or modifying therapy patients should test more often than usual. The role of SMBG in stable diet-treated patients with type 2 diabetes is not known

Chasing the prandial glucose spikes

Elevated postchallenge (2-h OGTT) glucose values have been associated with increased cardiovascular risk independent of FPG in some epidemiological studies. There are now pharmacological agents that primarily modify PPG and thereby reduce A1C in parallel. (since you have a therapy, you now are bothered about it) Thus, in individuals who have premeal glucose values within target but who are not meeting A1C targets, consideration of monitoring PPG 12 h after the start of the meal and treatment aimed at reducing PPG values <180 mg/dl may lower A1C.

Monnier L, Lapinski H, Colette C: Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetes Care 26:881 -885, 2003

Weighing pros & cons

Because the accuracy of SMBG is instrument and user dependent it is important for health care providers to evaluate each patients monitoring technique, both initially and at regular intervals thereafter. In addition, optimal use of SMBG requires proper interpretation AND USE OF the data in order to decide alterations in therapy. (heard of Suppandi) SMBG becomes handy when you need estiamtions at times when the lab is closed e.g. 3 AM, post dinner etc.

SMBG is not a panacea for all evils

You cannot ignore the laboratory, it helps verify if your meter is accurate, and of course reminds you to check your lipids, creatinine etc; i.e. a holistic approach to the management of diabetes.

COMMON RECOMMENDATIONS
In well controlled type 2 diabetes patients an idealistic goal would be to have at least a FBS and PPBS (breakfast) value done once a month. Pl. inform the patient how they need to prepare themselves for sampling. The frequency of BS estimations ultimately depends upon the clinical judgment of the physician; e.g. a patient with complications or in the peri-operative phase, during intercurrent illness, when initiated on glucocorticoid therapy, when the oral drugs are altered will require more intensive monitoring of glycemia since there will be fluctuations in the therapy according to the situation.

HbA1c: Recommendations ADA 2006

Perform the A1C test at least two times a year in patients who are meeting treatment goals (and who have stable glycemic control). Perform the A1C test quarterly in patients whose therapy has changed or who are not meeting glycemic goals. Use of point-of-care testing for A1C allows for timely decisions on therapy changes, when needed.

HbA1c
Measures average glycemia over the preceding 23 months and, thus, assess treatment efficacy. A1C testing should be performed routinely in all patients with diabetes, first to document the degree of glycemic control at initial assessment and then as part of continuing care. For any individual patient, the frequency of A1C testing should be dependent on the clinical situation, the treatment regimen used, and the judgment of the clinician.

Advantages of HbA1c
It can be done any time of the day. Helps to detect malingering. A high A1c can help influence therapy e.g. an elevated value would indicate that monotherapy may not help achieve the target.

LIMITATIONS OF A1c TESTING

Conditions that affect erythrocyte turnover (hemolysis, blood loss) and hemoglobin variants must be considered, STANDARDISATION is another malady; there are many methods Immunosorbent assay ELISA, RIA; many kits have added to the confusion. It doesnt detect hypos It doesnt help in adjustment of the day-to-day insulin dosage.

Whats in a name?
Glycated Hb Glycosylated Hb Glycosylated HbA1c.

The best assessment of glycemic control:

combination of the results of the patients SMBG testing (as performed)/ recent BS reports and the current A1C result The A1C should be used not only to assess the patients control over the preceding 23 months but also as a check on the accuracy of the meter (or the patients self-reported results) and the adequacy of the SMBG testing schedule. Lack of correlation between the two should alert the physician to probe for the cause.

Glycemic goals Recommendations

Lowering A1C has been associated with a reduction of microvascular and neuropathic complications of diabetes. The A1C goal for patients in general is an A1C goal of <7%; this is achieved by having a Fasting < 100 mg and prandial glucose < 180 mg% (ADA), it would be wonderful to chase 140mg% (AACE goal) The A1C goal for the individual patient is an A1C as close to normal (<6%) as possible without significant hypoglycemia. Wait for ACCORD

 Less stringent treatment goals may be appropriate for patients with a history of severe hypoglycemia, patients with limited life expectancies, very young children or older adults, and individuals with comorbid conditions. Aggressive glycemic management with insulin may reduce morbidity in patients with severe acute illness, perioperatively, following myocardial infarction, and in pregnancy.

Thanks