Nerium Oleander

Outline of the Discussion

Basic Information
Toxins Present Receptors Uses Symptoms and Treatment

Nerium Oleander
is a flowering shrub or small tree
which bears clusters of flowers. The

plant originated from Eurasia and is

often used as an ornamental plant.

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Toxins
Cardiac Glycosides
nerioside oleandroside saponins Digitoxigenin

Neriin
Oleandrin

Toxins
Oleandrin

Oleandrigenin (16-Acetylgitoxigenin), Oleandroside

Toxins
Saponin
consist of a polycyclic aglycone that is either a choline steroid or triterpenoid attached via C3 and an ether bond to a sugar side chain

Toxins
Digitoxigenin
obtained especially by hydrolysis of digitoxin

Receptors
Peroxisome Proliferator-activatedreceptor- (PPAR-) ;;

Receptors
PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms.

Uses
used for heart
conditions

painful menstrual
periods

asthma
epilepsy

Leprosy
malaria

Cancer
venereal disease

ringworm
indigestion

Toxicity
Oleander poisoning occurs when
someone sucks nectar from the flowers or chews leaves from the

oleander or yellow oleander plant.

Poisoning can also happen if you eat honey made by bees that used the oleander plant for nectar or when inhaled smoke from the oleander leaves are
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Symptoms
Nerium oleander toxicity typically
arise within a few hours after consuming this plant. This include nausea, vomiting, diminished appetite, bloody diarrhea,

drowsiness, dizziness or dilated

pupils.

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Symptoms
Handling Nerium oleander may also cause skin irritation, such as redness

or itching.

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Complications
Eyes, ears, nose, mouth, and throat
Blurred vision Vision disturbances, including halos

Heart and blood

Irregular or slow heartbeat Low blood pressure Weakness
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Complications
Gastrointestinal
Diarrhea

Loss of appetite
Nausea Stomach pain Vomiting
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Complications
Nervous system
Confusion Drowsiness

Death
Depression

Fainting
Headache

Disorientation
Dizziness

Lethargy

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Treatment
activated charcoal in conjunction
with intravenous fluids gastric lavage

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Treatment
breathing support and
electrocardiogram

Digoxin-specific antibody fragments

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References
http://www.rightdiagnosis.com/o/oleander_poiso ning/intro.htm
http://www.livestrong.com/article/395483nerium-oleander-toxicity/#ixzz2GQ6blvWV http://health.nytimes.com/health/guides/poison/ oleander/overview.html http://www.hindawi.com/journals/ije/2012/94 7187/

Thank You !