Digestive System
Objectives
2. To understand the mechanism of defecation
GI Wall
SNS PNS
Intense vasoconstriction to Inc local blood flow due to
dec blood flow (direct) inc glandular sec (indirect)
Needed for emergency for
inc blood flow to other
areas during heavy ex and
circulatory and
hemorrhagic shocks
Digestive System
GI Reflexes:
Within gut wall From gut to From gut to
ENS prevertebral SC/brainstem
sympathetic and back to GIT
ganglia and back
to GIT
For GI secretion, Gastrocolic By vagus n
peristalsis, Enterogastric Pain (inhibitory)
mixing cx, local Colonoileal defecation
inhibition
Digestive System
Gastric inhibitory Mucosa of upper Fatty acids and Dec stomach motor
peptide small intestine amino acids, activity (mild),
carbohydrate (less) slowing emptying of
gastric contents into
duodenum when
upper small
intestines
overloaded);
stimulates sec of
insulin by pancreas
*chewing reflex
*rate of digestion depends on total surface area
exposed to digestive sec
2. Swallowing (Deglutition)
3 stages: voluntary, pharyngeal (reflex),
esophageal
Digestive System
Digestive System
Secretory glands:
2. Digestive enzymes – all are proteins
Autonomic Regulation
SNS PNS
Slight to moderate inc in Inc rates of alimentary
sec glandular sec (upper
Vasoconstriction (so tract and of large
reduces sec more than intestine)
inc)
Digestive System
Secretion of Saliva (800-1500 mL/day; pH: 6.0-7.0,
suitable for ptyalin; has K and bicarbonate)
Parotid serous
Buccal mucus
Sour taste
Rough Smooth objects in mouth
Favorite foods
PNS
Digestive System
4. Tubular glands
1. Oxyntic/gastric (acid-forming) – HCl, pepsinogen
(+HCl = pepsin for protein digestion in acid
solution of pH of 5), intrinsic factor (for vit B12
absorption in ileum), mucus (prox 80% stomach)
2. Pyloric – mucus (alkaline), gastrin (distal 20%)
Digestive System
Phases of Gastric Secretion
Even before food enters
stomach; 20% of total
gastric sec; inc c greater
appetite
chyme
Digestion Inactive Secretions Activated Enzymes (p secreted into
intestinal tract)
Protein Trypsinogen trypsin (most), chymotrypsin, etc
Chymotrypsinogen
Carbo pancreatic amylase
Water Diffusion
Fats
Digestive System
electrolytes/day
Digestive System