By
Dr. M. Anthony David, MD
Professor of Physiology
G
L
A
N
02/09/08
D NOMAD:ENDOPHYSIOL: THYROID PARA 3
THYROID GLAND
EMBRYOLOGY:
Begins development in the 4thwk
of IUL
Hormones secreted from the 12th
week.
Fetal Thyroid Hormones useful for:
Intermediary
metabolisms:
CHO
Fats
Proteins
02/09/08 NOMAD:ENDOPHYSIOL: THYROID PARA 11
EFFECTS OF THYROID
HORMONES: Developmental
REGULATION:
Growth in Homeotherms
Metamorphosis in
Poikilotherms.
CONTROL:
Protein
02/09/08 Synthesis.
NOMAD:ENDOPHYSIOL: THYROID PARA 12
CALORIGENESIS: Heat Production
How?
By increasing Oxygen consumption
in:
Heart
Gastric Mucosa
Smooth Muscles
Kidneys
Liver
Skeletal Muscles.
02/09/08 NOMAD:ENDOPHYSIOL: THYROID PARA 13
CALORIGENESIS: Heat
Production
No response to Thyroxine in
T: Testes
U: Uterus
L: Lymph nodes
S: Spleen
A: Anterior Pituitary
Results:
Tachycardia
Sensitivity to Adrenal Lipolysis.
Catecholamines
Proportion of
HYPOTHALAMUS
TRH
STIMULATING
ANT
PIT INHIBITORY
TSH
Paper test
Warm, soft skin
Sweating
BMR: +10 to
+100
02/09/08 NOMAD:ENDOPHYSIOL: THYROID PARA 36
HYPERTHYROIDISM: GRAVE’S
DISEASE
EXOPHTHALMIC
GOITRE:
Exophthalmos:
Protruding eyeballs
Is an autoimmune
disorder
Can be also
Hashimoto’s
Thyroiditis
Iodide trapping.
Others block iodisation of
Tyrosine.
Examples:
Perchlorates
Thiocyanates
Rutabagas &
Turnips
02/09/08 NOMAD:ENDOPHYSIOL: THYROID PARA 39
02/09/08 NOMAD:ENDOPHYSIOL: THYROID PARA 40