Regions manifesting a rise in rCBF (ACC, insula & parahippocampal gyrus) showed a similar response with 0.5 MAC SV also.
A TCI system
A TCI system is very convenient because a syringe pump with a built-in DiprifusorTM can adjust the Propofol dose by means of just inputting the expected target concentration of Propofol during anesthetic management after inputting the patients characteristics such as weight and age before starting administration.
A TCI system
However, confirmation of matching dose with predicted plasma concentration (Cp) displayed on the syringe pump is thought to be always necessary for preventing human errors such as inputting incorrect weight.
A TCI system
It has been calculated the predicted Cp using TIVAtrainerTM (http://www.eurosiva.org/; accessed on May 1, 2010) with Marshs parameter when it was assumed that Propofol was administered using TCI with 3 g/mL of the target concentration in a 40-year-old male with a height of 170 cm and weight of 70 kg (Figure 1).
Advantages of TCI
A. Benefits to Pharmaceutical Companies 1. Maintenance of a desired drug concentration may improve therapeutic effect and minimise toxicity or undesirable effects associated with high peak concentrations obtained with bolus dosing. 2. Use of TCI in drug development allows early determination of concentration/effect data. A number of stepped drug concentrations can be studied in the same subject. Early availability of PK/PD data may help to shorten drug development times. 3. Simplification of dosing strategy and improved ease of use
TCI Propofol
A comparison of three different TCI RF rates during TCI PR for oocyte retrieval.
Coskun D, Gunaydin B, Tas A, Inan G, Celebi H, Kaya K. A comparison of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion for oocyte retrieval. Clinics (Sao Paulo). 2011;66(5):811-5. Department of Anaesthesiology and Reanimation, Faculty of Medicine, Gazi University, Ankara, Turkey. dcoskun@gazi.edu.tr