Ouchi,201 1
Adipokines
Heart Vascular tissue Skeletal muscle Liver
Cardiovascular function
Insulin sensitivity
ApN Leptin Apelin
Adipocytes
Visfatin
Stimulation Inhibition
E. Maury, 2010
Inflamati on
4
APELIN
Adiponectin
The largest amount adipokin in the bloodThe gen located on chromosome 3q27
MMW
LMW
In Japanese non obese subject adipoQ levels 3-30 g/dl and decrease 50% in obesity
6
Pathophysiology of atherosclerosis
LDL
ROS
DL oxL
-1 LOX
endothel
Intima
Macrophage
DC
T limphocyte
Media
SMC
Atherosclerosis
Pathophysiogy
Bone marrow
Monocyte
M-1 VCA ICA M-1
DL oxL
-1 LOX
endothel
DC
Intima
di ffe
i nt e r
M CP
n io t a
-1
C M-
SF
T limphocyte
Media SMC
Atherosclerosis
Pathophysiogy
-1 M-1 ICAM A VC
-1 LOX
Intima
Macrophage
PD GF TN F -
Media
Mi gr
ati o
SR
Foam cell
References
Ouchi,1999 Fasshauer, 2003
IL-6
CRP
Insulin
Glucocorticoids
Fasshauer, 2002
Beta-adrenergic agonist
inhibits gene expression of adiponectin
Fasshauer, 2001
Fasshauer, 2002
Han, 2007 11
References
Hotta,2000; Kobayashi,2004 Esposito,2003; Monzillo, 2003 Miyazaki,2003; Iwashima,2005 Fasshauer, 2001
Renin-Angiotensin System Blocking Agent Koh, 2005 Termocapril and Ramipril increase adiponectin levels Koh,2004; Koh,2006; Losartan and Candersartan increase adiponectin levels PPAR Agonist Chinetti , 2004 PPAR Agonist induces AdipoR2 on human primary macrophage Chinetti , 2004; Koh,2005; Fenofibrate increase adiponectin levels
Koh,2006
Hypoglicemic Drugs
Increase plasma adiponectin levels in elderly patients Tsunekawa, 2003 with type 2 diabetes Metformin does not alter plasma adiponectin levels in obese patients Philips, 2003 with type 2 diabetes
Glimepiride
Statin Simvastatin, atorvastatin, and rosuvastatin do not change plasma Koh, 2004; Koh, 2005; Avest,
levels of adiponectin 2005
12
Barseghian, 2011
13
Adiponecti n
Inflammation
SMC
Atherosclerosis
Summary
Adipose tissue dysfunction obesity associated with CHD in
Adiponectin is adipokine which has the effect of anti-atherosclerotic Adiponectin has been the target of future research to fight against atherosclerotic Optimism arising to recombinant adiponectin as a treatment and prevention of CVD
15
Human Adipocyte
16