-

- IgE (side chain) penicillin

- T cell ( )
sulfamethoxazole

- NSAIDs


- Beta-lactam
- side chain

 < 10
anaphylaxis 0.015 0.004
. penicillins 1020 skin test
Skin test :
- 60

 18.7 penicillin
ampicillin / amoxicillin
- diamino acyl side
chain
- Epstein-Barr virus,
leukemia allopurinol
( 69-100)

 0.9 - 2.8
* anaphylaxis 0.1 0.0001
* Penicillin ( 10.9-13.3)
1 cep. = 7.2 10.9%
2 cep = 1.9%
3 cep = 0.8 %
7

cephalosporin 86.7

..
generation

* Cephalosporin
( 1 , 2 , 3 )
* Cephalosporin
side chain (R1)

* .. 1987
- 50 penicillin
skin test penicillin
skin test imipenem

* .. 2000
- imipenem
penicillin 9.5

*
Sulfonamide

- IgE
- metabolism

 IgE ( )

- Anaphylaxis , urticaria,angioedema

Non-IgE
- Hemolytic anamia,

Interstitial
nephritis, maculopapular exanthem, SJS

* Skin test: (
quinolone
histamine)

* Desensitization :
*
IgE

* 1:1,000- 1:10,000
* 3 -13
* 60

- phenytoin : 2.3 4.5 :10,000

- Carbamazepine : 1-4.1 : 10,000

* aromatic
anticonvulsants 70 - 80

* phenytoin , phenobarbital,
carbamazepine
* BZD, valproic acid, gabapentin ,
topiramate, vigabatrin

. 30 40 /

ASA NSAIDs
15 60
- nasal congestion, severe
asthma, anaphylaxis (dose
dependent)

 ASA & NSAIDs :

urticaria, angioedema,pruritus,
dyspnea, rhinitis

:Celecoxib = 1.3 6.6%

:Paracet = 15.6%
:nimesulide = 2.8-17.6%
:meloxicam = 4.1%


- paracetamol salsalate
COX2
- Graded challenge ASA
150 325 650 mg
NSAIDs
- Desensitization ( )
ASA 3-10 mg