Alireza Mehrdadfar Transport Phenomena in Biological system

Dec. 7, 2013

Modeling of Hydrogels in Controlled release in Drug Delivery

Professor: Dr. Osfouri

Overview
Introduction Hydrogel Design & modelling criteria for hydrogels in drug delivery formulations Drug

Key findings / results Results 1 Results 2 Conclusion

release mechanisms for Hydrogel

Diffusion Swelling

Fit of the model to the experimentally determined Conclusion

Introduction

Since the establishment of the first synthetic hydrogels by Wichterle and Lim in 1954 the growth of hydrogel technologies has advanced many fields ranging from food additives to pharmaceuticals to biomedical implants

A successful drug delivery device relies not only on intelligent network design but also on accurate a priori mathematical modeling of drug release profiles.
In a complimentary fashion, a quantitative mathematical understanding of material properties, interaction parameters, kinetic events, and transport phenomena within complex hydrogel systems assists network design by identifying the key parameters and mechanisms that govern the rate and extent of drug release

Hydrogel
Hydrogels

are polymeric networks that absorb large quantities of water while remaining insoluble in aqueous solutions due to chemical or physical crosslinking of individual polymer chains.

For

example, hydrogels are excellent candidates for encapsulating bio macromolecules including proteins and DNA due to their lack of hydrophobic interactions which can denature these fragile species

Hydrogel

Hydrogel

2, =

Vp ratio of polymer volume Vg swollen gel volume

number average molecular weight between crosslinks

polymer volume fraction in the swollen state

M n is the average molecular weight of the linear polymer chains, is the specific volume of the polymer, V1 is the molar volume of water, and 12 is

the polymerwater interaction parameter

network mesh size

Hydrogel

Modelling & Design criteria for hydrogels Drug delivery

Molecule release mechanisms for hydrogel Modelling

Diffusioncontrolled

Swellingcontrolled

Diffusion-controlled delivery systems

Diffusion-controlled

is the most widely applicable mechanism for describing drug release from hydrogels. Fick's law of diffusion with either constant or variable diffusion coefficients is commonly used in modeling diffusion-controlled release.

Diffusion-controlled

hydrogel delivery systems can be either reservoir or matrix systems

Diffusion-controlled delivery systems

For a reservoir system

For a matrix system

From solving two system

Power law function

Swelling-controlled delivery systems

In diffusion-controlled delivery systems, the time-scale of drug diffusion, t, (where t=(t)2 /D and (t) is the time-dependent thickness of the swollen phase) is the rate-limiting step while in swelling-controlled delivery systems the time-scale for polymer relaxation () is the rate limiting step. The Deborah number (De) is used to compare these two time-scales

Diffusion-controlled delivery systems

Power law function

a sequential layer model

Fit of the model to the experimentally determined

Releases The drug release kinetics of propranolol hydrochloride
in 0.1Mphosphate buffer (pH 7.4)

Conclusion
Hydrogels

have played a very important role in biomedical applications. With increasing efforts devoted to controlled molecule release, the applications of hydrogels will continue to grow in the future.
network design and accurate mathematical modeling are keys to tuning the drug release rates as well as to modulating tissue regeneration.

Proper

References
J.

Siepmann, N.A. Peppas, Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC), Adv. Drug Deliv. Rev. 48 (2001) 139157. Lin, Andrew T. Metters , Hydrogels in controlled release formulations: Network design and mathematical modeling, Adv. Drug Deliv. Rev. 58 (2006) 13791408.

Chien-Chi

The End