PowerPoint Lecture Slides prepared by Vince Austin, University of Kentucky

The Cardiovascular System:

Human Anatomy & Physiology, Sixth Edition Elaine N. Marieb

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Heart Anatomy

Figure 18.1
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Pericardial Layers of the Heart

Figure 18.2
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External Heart: Anterior View

Figure 18.4b
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External Heart: Posterior View

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Figure 18.4d

Gross Anatomy of Heart: Frontal Section

Figure 18.4e
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Pathway of Blood Through the Heart and Lungs

Figure 18.5
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Coronary Circulation: Arterial Supply

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Figure 18.7a

Coronary Circulation: Venous Supply

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Figure 18.7b

Heart Valves

Heart valves ensure unidirectional blood flow through the heart

Atrioventricular (AV) valves lie between the atria and the ventricles AV valves prevent backflow into the atria when ventricles contract Chordae tendineae anchor AV valves to papillary muscles
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Heart Valves

Aortic semilunar valve lies between the left ventricle and the aorta
Pulmonary semilunar valve lies between the right ventricle and pulmonary trunk Semilunar valves prevent backflow of blood into the ventricles

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Heart Valves

Figure 18.8a, b
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Heart Valves

Figure 18.8c, d
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Atrioventricular Valve Function

Figure 18.9
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Semilunar Valve Function

Figure 18.10
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Microscopic Anatomy of Heart Muscle

Cardiac muscle is striated, short, fat, branched, and interconnected The connective tissue endomysium acts as both tendon and insertion Intercalated discs anchor cardiac cells together and allow free passage of ions

Heart muscle behaves as a functional syncytium

PLAY InterActive Physiology: Cardiovascular System: Anatomy Review: The Heart

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Microscopic Anatomy of Heart Muscle

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Figure 18.11

Cardiac Muscle Contraction

Heart muscle:
Is stimulated by nerves and is self-excitable (automaticity) Contracts as a unit Has a long (250 ms) absolute refractory period

Cardiac muscle contraction is similar to skeletal muscle contraction

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Heart Physiology: Intrinsic Conduction System

Autorhythmic cells:
Initiate action potentials

Have unstable resting potentials called pacemaker potentials

Use calcium influx (rather than sodium) for rising phase of the action potential
InterActive Physiology: Cardiovascular System: Cardiac Action Potential

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Pacemaker and Action Potentials of the Heart

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Figure 18.13

Heart Physiology: Sequence of Excitation

Sinoatrial (SA) node generates impulses about 75 times/minute

Atrioventricular (AV) node delays the impulse approximately 0.1 second Impulse passes from atria to ventricles via the atrioventricular bundle (bundle of His)

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Heart Physiology: Sequence of Excitation

AV bundle splits into two pathways in the interventricular septum (bundle branches)
Bundle branches carry the impulse toward the apex of the heart

Purkinje fibers carry the impulse to the heart apex and ventricular walls

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Heart Physiology: Sequence of Excitation

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Figure 18.14a

Heart Excitation Related to ECG

Figure 18.17
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Extrinsic Innervation of the Heart

Heart is stimulated by the sympathetic cardioacceleratory center Heart is inhibited by the parasympathetic cardioinhibitory center

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Figure 18.15

Heart Sounds

Heart sounds (lub-dup) are associated with closing of heart valves

First sound occurs as AV valves close and signifies beginning of systole

Second sound occurs when SL valves close at the beginning of ventricular diastole

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Cardiac Cycle

Cardiac cycle refers to all events associated with blood flow through the heart
Systole contraction of heart muscle

Diastole relaxation of heart muscle

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Phases of the Cardiac Cycle

Ventricular filling mid-to-late diastole

Heart blood pressure is low as blood enters atria and flows into ventricles

AV valves are open, then atrial systole occurs

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Phases of the Cardiac Cycle

Ventricular systole
Atria relax
Rising ventricular pressure results in closing of AV valves Isovolumetric contraction phase

Ventricular ejection phase opens semilunar valves

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Phases of the Cardiac Cycle

Isovolumetric relaxation early diastole

Ventricles relax
Backflow of blood in aorta and pulmonary trunk closes semilunar valves

Dicrotic notch brief rise in aortic pressure caused by backflow of blood rebounding off semilunar valves
PLAY InterActive Physiology: Cardiovascular System: Cardiac Cycle

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Phases of the Cardiac Cycle

Figure 18.20
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Cardiac Output (CO) and Reserve

CO is the amount of blood pumped by each ventricle in one minute

CO is the product of heart rate (HR) and stroke volume (SV)

HR is the number of heart beats per minute SV is the amount of blood pumped out by a ventricle with each beat Cardiac reserve is the difference between resting and maximal CO
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Cardiac Output: Example

CO (ml/min) = HR (75 beats/min) x SV (70 ml/beat) CO = 5250 ml/min (5.25 L/min)

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Regulation of Stroke Volume

SV = end diastolic volume (EDV) minus end systolic volume (ESV)

EDV = amount of blood collected in a ventricle during diastole ESV = amount of blood remaining in a ventricle after contraction

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Factors Affecting Stroke Volume

Preload amount ventricles are stretched by contained blood

Contractility cardiac cell contractile force due to factors other than EDV Afterload back pressure exerted by blood in the large arteries leaving the heart

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Frank-Starling Law of the Heart

Preload, or degree of stretch, of cardiac muscle cells before they contract is the critical factor controlling stroke volume Slow heartbeat and exercise increase venous return to the heart, increasing SV Blood loss and extremely rapid heartbeat decrease SV

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Preload and Afterload

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Figure 18.21

Extrinsic Factors Influencing Stroke Volume

Contractility is the increase in contractile strength, independent of stretch and EDV Increase in contractility comes from:
Increased sympathetic stimuli Certain hormones Ca2+ and some drugs

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Extrinsic Factors Influencing Stroke Volume

Agents/factors that decrease contractility include:

Acidosis
Increased extracellular K+

Calcium channel blockers

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Contractility and Norepinephrine

Sympathetic stimulation releases norepinephrine and initiates a cyclic AMP secondmessenger system
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Figure 18.22

Regulation of Heart Rate

Positive chronotropic factors increase heart rate Negative chronotropic factors decrease heart rate

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Regulation of Heart Rate: Autonomic Nervous System

Sympathetic nervous system (SNS) stimulation is activated by stress, anxiety, excitement, or exercise
Parasympathetic nervous system (PNS) stimulation is mediated by acetylcholine and opposes the SNS PNS dominates the autonomic stimulation, slowing heart rate and causing vagal tone

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Atrial (Bainbridge) Reflex

Atrial (Bainbridge) reflex a sympathetic reflex initiated by increased blood in the atria
Causes stimulation of the SA node

Stimulates baroreceptors in the atria, causing increased SNS stimulation

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Chemical Regulation of the Heart

The hormones epinephrine and thyroxine increase heart rate Intra- and extracellular ion concentrations must be maintained for normal heart function

PLAY

InterActive Physiology: Cardiovascular System: Cardiac Output

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BLOOD PRESSURE
Tekanan yang dibentuk oleh darah terhadap dinding pembuluh darah Sistole: pada saat jantung kontraksi Diastole: pada saat jantung relaksasi Tekanan Darah = Cardiac Output x Total Peripheral Resistance

ESC 2003

ESH 2003 & JNC VII(2003)

BP BP

ESH-ESC 2003 BP Classification

JNC 7 2003 JNC VII(2003) Bp Classification

Optimal
Normal High normal Grade 1 Hypertension (mild) Grade 2 Hypertension (moderate) Grade 3 Hypertension (severe)

<120 / <80
120-129 / 80-84 130-139 / 85-89 140-159 / 90-99 160-179 /100109 > 180 / >110

<120/<80
120-129 /80-84 130-139 / 85-89 140-159 / 90-99

Normal
Prehypertension Prehypertension Stage 1 Hypertension Stage 2 Hypertension

>160 / >100

Isolated Systolic Hypertension

> 140

< 90

Isolated Systolic Hypertension

Capillaries

Capillary Beds
Capillary beds consist of two types of vessels
Vascular shunt directly connects an arteriole to a venule

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Figure 11.10

Slide

Capillary Beds
True capillaries exchange vessels Oxygen and nutrients cross to cells Carbon dioxide and metabolic waste products cross into blood
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Figure 11.10

Slide

Diffusion at Capillary Beds

Figure 11.20

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Slide

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