• Comparison:
– Nigeria of 3 cases per 100,000 people (very low).
– USA 40 per 100,000
Incidence
• Some religious groups (Mormons & Seventh Day
Adventists) have much lower rates of colon
cancer.
– No booze or tobacco
– Chaste lifestyle?????
• Accumulation of mutations –
multi-step nature of cancer.
Other Risk Factors
• Family history. Some colon cancers are hereditary.
• Total
• Hemi
• Depending on
stage of
tumour
Chemotherapy
• For stage I tumours and above some form of
adjuvant therapy is normally recommended.
17p 75%
18q 75%
22q 50%
MSH1/MLH2
Summary
• Incidence, classification and treatment options for colon
cancer