Marzieh Hadei Koik Shuh Jie Heng Wen Zhuo Goh Sue Yin
Neurolinguistics
The study of the relationship between language and the brain .
Cerebral cortex
Top layer of the brain Contains wrinkles called Fissures. The Fissures increase surface area of the brain. Its huge . This feature makes humans different from animals .
Right hemisphere controls the left side of the body and vice versa . Any areas not dealing with our senses or muscles movements are called association area. The main connection between the two hemispheres is a bundle of nerves fibers known as Corpus callosum . Its primary function is to allow the two hemispheres to communicate with one another.
Corpus callosum
Split - brain
The corpus callosum make sure that there is a connection from the right side of the brain to the left side of the brain. A procedure in which the two hemispheres of the brain are isolated by cutting the connecting fibers ( corpus callosum ) .
Motor cortex
The strip of brain issue at the rear of frontal lobes Responsible for the voluntary movement Different parts of cortex control different part of body The motor cortex in the left hemisphere control the right part of body and vise versa.
Brocas area
Brocas area : in the left frontal lobe that directs muscle movements involved in speech . Language production area actually deals with taking words ,forming structured sentences. Basically, this area is your grammar center that puts the words together in a coherent fashion.
Brocas Area
Or Anterior speech cortex Marc Dax, during the rst years of the 19th century, concluded that the loss of language was more frequently associated with damages to the left half of the brain. After the 19th century physician Pual Broca , a French Surgeon , reported that damage to this specific part of the brain was related to extreme difficulty in producing speech.
Brocas Area
He believed out of 100 people with permanent language disorder caused by brain lesions approximately 97 will have damage on the left side.
Wernickes area
Or Posterior speech cortex Carl Wernicke was a German doctor , in the 1870s, reported that damage to this part of the brain was found among patients who had speech comprehension difficulties.
Wernickes area
in left Temporal lobe that is involved in language comprehension and expression . General rule - associated with language understanding that is, the meaning of words in a sentence rather than the sentence structure.
Example: sometimes people with damage to this area ramble meaninglessly, but can sometimes speak their words fluently.
Lateralization: The specialization of function between the left and right hemispheres of the brain. Lenneberg (1967) and others suggested that lateralization is a slow process that begins around the age of 2 and is completed around puberty. It has been found that children up to the age of puberty who suffer injury to the left hemisphere are able to relocalize linguistic functions to the right hemisphere, to relearn their first language with relatively little impairment. CPH.
While language production is left-lateralized in up to 90% of righthanded subjects, it is more bilateral, or even right lateralized in approximately 50% of left-handers. Thus, left handed people tend to be less lateralized than right-handed people. In terms of muscle movement and sensation, each hemisphere is responsible for half the body, the opposite half. The left hemisphere controls the right side of the body and vice versa. Stroke?
Left hemisphere : analytic tasks such as arithmetic Right hemisphere : recognition of familiar faces and melodies Language; Left hemisphere : grammar, vocabulary and literal meaning Right hemisphere : intonation and accentuation
Perhaps to differing degrees, complex mental activities involve the coordinated functioning of both hemispheres in the normal human brain. Example: The representation of language in the brain. Not every aspects of language is represented in the left hemisphere. Adults who have had their left cerebral hemispheres surgically removed lose most, but not all, of their linguistic competence. They typically lose their ability to speak and process complex syntactic patterns but retain some language comprehension ability. Right hemisphere?
Patients who suffer damage to the right cerebral hemisphere exhibit difficulty in understanding jokes and metaphors in everyday conversation. He was wearing a loud tie. Frequently misunderstand people: loudness and intonation as cues. Thus, the right hemisphere has a distinct role to play in normal language use. Although the left and right hemispheres have different abilities and different responsibilities, complex skills such as language do not always fall neatly into one hemisphere or the other.
Example: Counting is momentarily interrupted, but with nondominant deactivation, it resumes within 5 to 20 seconds. Yet if the dominant hemisphere is involved, dysphasic responses may persist for as long as 1-3 minutes.
Right/ left-handed/ ambidextrous left/ right/ tri lateralization for language? Early brain damage?
Shifting of lateralization: Brocas view that the right hemisphere can assume any language functions if damage occurs early enough. Rasmussen and Milner (1977) found that damage after five years of age rarely results in shift of laterality. CPH
All information presented to the right visual field is projected to the left (generally language dominant) hemisphere and vice versa.
Myers (1955) sectioned both the corpus callosum and the optic chiasm in a group of laboratory animals. Corpus callosums function not only to hold both hemispheres together. Experiment example: Monkeys. Learning in one hemisphere totally fails to transfer to the other hemisphere.
In vast majority, only the dominant hemisphere can produce verbal output, but the nondominant hemisphere is not without language abilities. Right hemisphere does have some language understanding, but it is mute.
The left and right hemispheres operate together as a team. Through the corpus callosum, messages are sent back and forth so that both hemispheres are involved in much of the neurological activity of the human brain. Most problem solving involves the capacities of both hemispheres, and often the best solutions to problems are those in which each hemisphere has participated optimally (Danesi, 1988).
The basic paradigm for this approach was created by Donald Broadbent (1954). Presented subjects with a sequence of three digits to one ear, while simultaneously presenting another sequence to the opposite ear. In administering this test, Kimura (1961) discovered that digits presented to the ear contralateral to the dominant hemisphere were reported more accurately. Kimura attributed this effect to cerebral dominance, coupled with the greater strength of the contralateral pathways over ipsilateral (on the same side) ones. When stimuli were presented monaurally, the right ear advantage was not observed.
The left hemisphere more quickly and accurately processes words (aural & written), identify letters and has an advantage when processing nonsense syllables and backward speech. The right hemisphere appears to do better when asked to process musical stimuli, human nonspeech stimuli (cough) and has an advantage during visual-spatial processing tasks.
Most of the input to your right ear goes to the left hemisphere of your brain. In general, the right ear shows an advantage for words, numbers, and Morse code, whereas the left ear shows advantage for the perception of intonation, melodies and environmental sounds.
These observations support the view that the left hemisphere is primarily responsible for language and that there are specific language areas within the left hemisphere.
Aphasia
Heng Wen Zhuo
What is Aphasia?
OED: from Greek, from aphatos 'speechless', from a- 'not' + phanai 'speak Some semantic purist dislike the term aphasia, pointing our that some aphasic patients actually produce more speech than normal people do. (Freemon, F.R, 1981)
Aphasia are the consequence of lesions of the language centres and/or connections, input and output pathways. Aphasias are not disorders of intelligence
They occur in symptom groupings; essential syndromes are identified (motor, sensory, conduction aphasia)
The syndromes depend on the localisation of the lesion Aphasias are the disorders of the normal flow of speech/ language processing
(Tesak & Code, 2008, p83)
What is Aphasia?
Acquired disorder of symbolic communication (Freemon, F.R, 1981) Difficulty in producing and understanding speech, reading , and writing What about those who are deaf ? Americal Sign Language
(Goodglass and Kaplan , 1963)
Specific disorder of higher cerebral function Not applicable to everyone who does not speak
(Freemon, F.R, 1981)
What is Aphasia?
A disorder of linguistic processing. Not a disorder of perception Not a disorder of movement Not a result of disordered thought processes.
(Mesulam, 2000)
What is Aphasia?
Aphasia not only disrupts communication but any ability whose final performance depends on the use of internal speech. - Decision making - Creativity - Ability to perform calculations often compromised because of a primary language defect
(-Marsel Mesulam, 2000)
Anxiety
Types of Aphasia
Fluent Aphasia VS Non-Fluent Aphasia mid of the 20th century, Goodglass and colleagues a major division between two types of aphasia : phrase length.
Fluent Aphasia
Fluent - the defining characteristic normal rate without the effort and hesitation association with non-fluent aphasia 4 types of Fluent Aphasia : Wernickes aphasia Transcortical sensory aphasia Conduction aphasia Anomia.
Types of Non-Fluent Aphasia Brocas Aphasia Transcortical motor aphasia Global Aphasia
brain ?
Becoming increasingly clear that the anterior language area is larger than previously supposed the area implicated in Brocas aphasia was now taken to encompass most of operculum, insula, and subjacent white matter, exceeding Brocas area (Mohr 1976, p202) cited in (Grodzinsky, 2000).
brain ?
Demonstrated that there is, at best, a weak association between site of lesion and syndrome.
Patient: Yes, sure, Me go, er, uh, P.T (physical theraphy) non ocot, speechtwo times readr.. ripe. .rike..uh write practiceget ting..better
(Fromkin et al, 2007)
Wernickes Area
no universally accepted boundary Usually defines as the region which causes Wernickes aphasia when damaged. One of the very few lesion sites that elicits two-way naming deficit May give impression of word representation storage, but unlikely
(Mesulam, 2000)
Wernickes Area
Wernickes area coordinates reciprocal interactions between the sensory representation of word forms & arbitrary (second-order or symbolic) associations that give them meaning)
(Mesulam, 2000)
Conduction Aphasia
Unable to repeat sentences verbatim Phonemic paraphasia Defective naming
Able to produce and comprehend simple sentences Right facial weakness
Conduction Aphasia
According to Geschwin (1965) , Lesion located in the arcuate fasciculus, the fibre tract that connects Brocas and Wernickes areas Arcuate fasciculus is part of the system required to assemble phonemes into morphemes, necessary for vocalization of word perceived auditorily or generated internally, in the minds ear
Global Aphasia
Almost complete loss of ability to comprehend language or formulate speech, Deliberate speech is reduced to a few words and sentences. May use the same word repeatedly in a vain attempt to communicate an idea.
Global Aphasia
Some non-deliberate automatic speech is preserved stock expletives, eg: Goddamn it- are used appropriately and with normal phonemic, phonetic and inflectional structures.
(Mesulam, 2000)
Global Aphasia
Other automatic speech routines , such as counting or reciting the days of the week, are often intact the ability to sing parts of previously learned melodies and their lyrics.
right facial weakness and right hemiplegia (paralysis of one side of body)
(Mesulam, 2000)
Global Aphasia
Presence or absence of hemiplegia is an important clue to the chance of recovery When hemiplegia is present, there is large degree of damage, patients severely aphasics from outset and show little or no improvement With transcient hemiplegia or no weakness, the patients tend to recover (Mesulam, 2000)
Aphasia Management
No standard approach , each require customized program . Following damage, the brain and its impaired functions tend to show some degree of spontaneous recovery, assuming the cause of damage is removed. The fact that therapeutic intervention is beneficial is generally accepted.
Aphasia Management
Techniques Melodic intonation therapy Syntax training programmes Visual Action Therapy Sentence Level Auditory Comprehension Treatment programme Visual Communication Therapy
(Mesulam, 2000)
Aphasia Management
In aphasia caused by stroke and head injury, the maximal recovery seems to occur in the first 3 months following onset.
Factors affecting success of therapeutic intervention: Premorbid characteristics of patient Types and severity of language / non-language defect Emotional status Human support
Images of dyslexic people's brains revealed: Larger right-hemisphere reduced structural integrity of the white-matter tracts linking the auditory cortices and the left inferior frontal gyrus a brain area involved in language processing, including speech production. activity in these areas was less correlated in the brain weaker communication between auditory and speech centres
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from dys - 'difficult' + Greek lexis 'speech' (apparently by confusion of Greek legein 'to speak' and Latin legere 'to read') A learning difficulty that is neurological in origin Affects the way people* read, write & spell* A processing problem A different way of thinking (visual) A most widely known Learning Disability (LD) NOTE! No physical manifestation Not a disease
What is DYSLEXIA?
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Type 1: Acquired dyslexia/Alexia What causes? Few cases: injuries, stroke or some other type of trauma Both Can Result? A disorder where reading skills are lost
Type 2: Developmental Dyslexia What causes? Common cases: Inherited, dyslexia often runs in families - Wide range of people, producing different symptoms and varying degrees of severity - 5 to 10% of the worlds population Result? A disorder where the reading skills are not gained/reading difficulties
83
2. Surface dyslexia: cannot recognise words as wholes can read regularly spelt words Example: regularly spelt word = bat /bt() irregularly spelt word = yacht /jt/(x)
understand the word produced, not what they see Example: worm = /warm/ = opposite of cold
(OGrady et al, 1996) 84
But people with dyslexia seem to have difficulty identifying and manipulating the speech sounds to be linked to written symbols
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one bilingual boy has reading problems in English, but none in Japanese Japanese is a halfway house between alphabetic languages and Chinese Readers often have to match shapes to syllables, a different task that is likely to involve a third, as yet unidentified brain region The boys left temporoparietal cortex was probably under active, whilst the unknown Japanese language-related area was fine
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Languages: A comparison
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Children with dyslexia have trouble learning to read, but the cause of their difficulties depends on what language they are attempting to learn: you could be fine in one language and struggling in the other," (Gabrieli, 2008) "Previous genetic studies suggest that malformations of the brain are associated with different genes (Tan L.H., 2004) neural basis of reading is complex and differs depending on the nature of the writing system, (Wydell T. N. & Butterworth B. B.,1999)
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A Testimonial
Cassandra is born dyslexic and suffered in school Confused over left and right shoes up to age of 12. Dyslexics cannot tell left from right. Couldnt distinguish a 2b pencil and went looking all over for a 2d Supportive teacher & parents Put many extra hours in her studies One-on-one attention & additional coaching Tried different studying techniques to find which worked best Scored 7As in her PMR Going to college Dreams to be a lawyer Cassandras remedy in triumphing despite dyslexia: DETERMINATION!
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video
http://www.youtube.com/watch?v=TxA_rvSNpx8 http://www.youtube.com/watch?v=UyyjU8fzEYU Important part : 11.17 mins & 12.40 mins
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References
Griggs, Richard A. Psychology: A Concise Introduction. p. 69. Boeree, C.G. (2004). "Speech and the Brain". Retrieved February 17, 2012. Taylor, I. & Taylor, M. M. (1990). Psycholinguistics: Learning and using Language. Pearson.
Beaumont, J.G. (2008). Introduction to Neuropsychology, Second Edition. The Guilford Press.
Ross ED, Monnot M (January 2008). "Neurology of affective prosody and its functional-anatomic organization in right hemisphere". Brain Lang. 104 (1): 5174. George MS, Parekh PI, Rosinsky N, Ketter TA, Kimbrell TA, Heilman KM, Herscovitch P, Post RM (July 1996). "Understanding Emotional Prosody Activates Right Hemisphere Regions". Arch Neurol. 53 (7): 665670. Brown, H.D. (2007). Principles of Language Learning and Teaching. New York: Pearson.
Fadiga, L., Craighero, L., & DAusilioa, A. (2009). Brocas Area in Language, Action, and Music. THE NEUROSCIENCES AND MUSIC III DISORDERS AND PLASTICITY.
Reference
Siegel, L.S., Paediatr. Child Health. 11(9), 581587 (2006). Siok, W. T. et al. Proc. Natl Acad. Sci. USA 105, 5561-5566 (2008). Siok, W. T., Perfetti, C. A., Jin, Z. & Tan, L. H. Nature 431, 71-76 (2004). Wydell T. N. & Butterworth B. B. Cognition, 70. 273 - 305(1999). Mesulam, M.M (2000) Principles of Behavioral and Cognitive Neurology, second edition. Oxford University Press
http://www.ncld.org/types-learning-disabilities/dyslexia/what-is-dyslexia
Questions
1. Please explain about the strip of brain issue at the rear of frontal
Questions
5. Based on the parts of the video clips shown from (Jills Stroke of insight), explain what was happening to her, by relating the phenomenon to what has been mentioned about Aphasia. 6. Perform a dialogue between a non-aphasic individual, and an aphasic individual (either Brocas aphasics or Wernickes aphasic).
Questions
7. In this fast moving technology era, do you think dyslexics find life easier or more challenging? Support your answer with 2 justifications. 8. If a child cannot tell his left shoe from his right shoe by the age of 7 or 8, he is most likely dyslexic.
a) What can be done to help him put on his shoes correctly? b) Why will your suggestions be successful?
The End
Thank You
Stress ??? @ .@