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WHY LUPRON IS USED

IN IVF TREATMENT
Introduction To Lupron
O Lupron (leuprolide) overstimulates the body's own
production of certain hormones, which causes that
production to shut down temporarily. Leuprolide reduces
the amount of testosterone In men or estrogen in women.
O Lupron is used in men to treat the symptoms of prostate
cancer. Lupron treats only the symptoms of prostate
cancer and does not treat the cancer itself.

Why Lupron Is Used In IVF
Treatment
O Lupron
- Has several possible uses in assisted reproduction: as the
trigger injection prior to egg retrieval to reduce the risk of
hyperstimulation
- As part of the flare protocol to help women who
respond poorly to fertility medications.
- Suppression of the pituitary to prevent ovulation

How Lupron Works In IVF
O Lupron acts by suppressing the pituitary gland (the gland which
is normally responsible for triggering ovulation). However, before
suppression occurs, Lupron will briefly stimulate the pituitary
causing an increase in the pituitary hormones LH (luteinizing
hormone) and FSH (follicle stimulating hormone). This is called
the agonist or flare phase (see picture). If the Lupron is continued,
it will eventually stop the pituitary from producing LH and FSH.
This is known as the suppression phase.
O Since it requires an extended period time to reach the suppression
phase, Lupron is usually started a few weeks before starting the
other medications needed for a particular treatment.
How Lupron Works In IVF
O This allows the patient to get past the stimulation phase
and into the suppression or desensitization phase.
O During the suppression phase, spontaneous ovulation will
not occur. You may hear the staff refer to the patient during
this phase as being down-regulated or "suppressed". This
suppression effect will even persist for a few weeks after the
Lupron is stopped.
O Today, Lupron suppression is used primarily for frozen
embryo transfer cycles and egg donation cycles. Some
programs may still use Lupron for fresh IVF cycles .


How Lupron Works In IVF
O At IVF1, we use a newer class of medications to prevent premature
ovulation in fresh IVF cycles. We like to use Cetrotide or Antagon
instead of Lupron.
O The flare effect of Lupron can be used at the beginning of a fresh
IVF cycle to help stimulate the development and maturation of
eggs. Lupron is given for a few days and then injectable fertility
medications are started. The flare protocol is rarely used anymore
since it does not appear to produce any benefit over other simpler
protocols.
How Lupron Works In IVF
O The flare effect of Lupron can also be used at the end of an IVF
stimulation in place of the hCG trigger injection. This use of
Lupron is primarily reserved for women who have responded too
vigorously to the fertility medications and are at risk for ovarian
hyperstimulation syndrome.
O You can buy Lupron online n isrameds.com with lower price
which you will not get anywhere else.
Contact Us
O Phone : 1-866-477-2289 ,
1-866-ISRA-BUY Or 1-877-247-4717
O Email :Address : IsraMeds.Com Online Pharmacy PO Box
5029 Yavne, Israel 80500
O SALES@IsraMeds.Com
O Fax : 1-888-477-2365

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