Microbiological study correlated with

pathological aspects of newborn enterocolitis

Camelia Budisan (1), Rodica Ilie (2), Constantin Ilie (1), !natescu Ileana (1),
Mirabela "ima (1), Ioana Bortea (1), Cristina Moldo#an (1)
Results

$n important incidence of the enterocolitis among the total newborns with letal e#olution in the studied
period (%,&&')(

$ great pre#alence of the disease to the premature newborn &&,&&'()*2%) + (Chart 1) and the age to the
death , (-able 2).

In abnormal pregnancy and birth / maternal infections 11,%0'. premature rupture membrane 11,21'.
coloured amniotic li3uid 22,42' . $56$R less than 4 , 41,)2' . intensi#e therapy needed to birth
27,12'(

-he microbiological study re#ealed / !nterobacter 11,11'. 5yocianic %,0'. !scherichia coli &,%'.
8taphilococus aureus 22,22'. Candida albicans %,0'. 9lebsiella 11,11' + (Chart &).
5athological forms of the enterocolitis were / pyo+haemorrhagical %%,%%'. haemorrhagical 22,22' +
(:ig( 1, 2).

5athological complications disco#ered were / peritonitis 2),22'. bowel perforation 10,11' + (:ig( &, 0)(
:ig( 2 ;aemorrhagical necroti<ing
enterocolitis, with thrombosis of some loops
Conclusions
=e consider that in the Bell III necroti<ing enterocolitis, the ris> factors as/ maternal infections during the
pregnancy,
prematurity, intensive therapy needs at birth, infectious factors, lead to hypo?ia with bacterial migration from the
intestinal lumen, inhibition of suppresor pathways, massi#e cyto>ines release with systemic sepsis and multiple organ
failure(
@ecroti<ing enterocolitis remains one of the most common emergencies for the newborn because of the usual
complications / peritonitis and bowel perforation, leading to death(
References
1. Hsueh W, Caplan MS, Qu W, !an ", "e #laen $%, %on&ale&'Crussi (. )eonatal necroti&ing enterocolitis* clinical considerations and pathogenetic concepts. #ediatr "ev
#athol +,,-./011*/'+-.
+. Henry MC, 2a3rence Moss R. Surgical therapy for necroti&ing enterocolitis* bringing evidence to the bedside. Semin #ediatr Surg +,,4.150-1*161'7,.
-. 2in #W, Stoll 89. )ecrotising enterocolitis. 2ancet +,,/.-/60745-1*1+:1'6-.

011 ;niversity of Medicine and #harmacy, )eonatology, !imisoara, Romania.
0+1 <mergency Children Hospital, #athology, !imisoara, Romania
:ig(1 Classic findings of diffuse pyo+
haemorrhagical necroti<ing enterocolitis
:ig( & ;(!(, ?17( "estruction of #illi, dilated
capillary and inflammatory cells
:ig( 0 ;(!(, ?27( @ecroti<ing peritonitis, with
thrombosis and some areas of pneumatosis
8-A"B
B!$R8
$6! C: -;! @!=BCR@8
-C -;! "!$-; ("$B8)
1+% 1+10 14+21 22+&7
2770 & 2 1 1
2774 0 2 1 2
2772 2 1 + 2
277% 1 1 + +
2771 + + + 2
277) + + + 2
-C-$D
17 2 2 )
-able 2 $ge of the newborn
Chart 1 5rematurity Chart 2 Microbiological study
8ac=ground
=e intended to determine the pre#alence of the microbiological pathogens in necroti<ing enterocolitis,
correlated with the pathological aspects and abnormal pregnancy and birth signs, as an important neonatal
death cause(
Microbiological study
3,70%
22,22%
11,11%
11,11%
37,06%
7,40%
7,40%
Enterobacter
Pyocianic
Escherichia coli
Staphilococusaureus
andida albicans
!lebsiella
"n#no$n
%ncidence o& pre'aturity
33(33 %
66(66 %
Premature
newborns