KELOMPOK A.

1
1. Alfian Reddy S (0710710001)
2. Richi Aditya (0710710003)
3. Dwi Priyadi D (0710710004)
4. Felix Kusmana (0710710007)
5. Sandy Wijaya (0710710018)
6. Sujarot Dwi S (0710710021)
7. Joshua Sutikno (0710710023)
8. Jefry Pratama S (0710710029)
9. B. Indah Alona (0710710033)



10. Davin Pratama C (0710710036)
11. John Tuahta .P.S (0710710038)
12. Jeffi Wahyu (0710710044)
13. Andreas R. (0710710046)
14. Novia A. Astiti (0710710050)
15. Madya Kusuma (0710710055)
16. Akmal Fawzi (0710710056)
17. Vita Uxiana (0710710070)
18. Rizky Tania F (0710710077)

Modul 1 (No : 1-3)
Anggota Kelompok :

Modul Answer
1.
Name the three layer of the skin.
What composes them ?
What are each their function ?

2 Layer of the Skin
E
p
i
d
e
r
m
i
s

D
e
r
m
i
s

H
i
p
o
d
e
r
m
i
s

Thick skin
Thin skin
4
LAYER OF THE SKIN
EPIDERMIS
Permeabilitiy barier
Protection from patogen
UV protection
Wound repair
Termoregulation
Komponen Penyusun:
Keratinosit, sel merkel, sel langerhan dan grainstain.
Cont (Layer Of The Skin...)
Dermis
Protection from patogen
Termoregulation
Sensation
Wound repair
Physical apearence
Layer Composes Consist Of:
Papilary layer, reticular layer, vaskuler, free nerve,
dermatan sulfan, hair folicle, sweet gland,
Sebacea gland, arrector pili muscle
Cont (Layer Of The Skin...)
Hipodermis
Termoregulation
Sensation
physical appearence
Komponen penyusun:
Jaringan lemak, sensori aparatus, blood vesel, nerve
Modul Answer
2. What are the four primary
function Of Skin :
Four Primary Function of Skin
2. What are the four primary function Of Skin :
a. Barrier Function and Prevention of
desiccation.
b. Immune Surveillance.
c. Cutaneous Sensation.
d. Temprature Control
The Other Function of Skin
FUNCTION TISSUE LAYER SOME ASSOCIATED DISEASES

Permeability barrier Epidermis Atopic dermatitis
Protection from pathogens Epidermis Verruca vulgaris
Dermis Cellulitis
Thermoregulation Epidermi Ectodermal dysplasias
Dermis Raynaud
Hypodermis Hyperthermia
Sensation Epidermis Diabetic neuropathy
Dermis Leprosy
Hypodermis Pruritus
Ultraviolet protection Epidermis Xeroderma pigmentosum
Wound repair/regeneration Epidermis Keloid
Dermis Pyoderma gangrenosum
Physical appearance Epidermis Melasma
Dermis Vitiligo
Hypodermis Scleroderma

Modul Answer
3. What are the Etiological
factors may cause skin disease?
What Is Pathomechanisms of the
generation of skin lesions
(Skin Changes) ?
ETIOLOGY SKIN DISEASE
Kongenital
Herediter
Non-herediter

Acquaire
External faktor
Agent
Physics
chemical
Internal faktor
Sistemik
Genetik
Physiology
Drug
Internal disease


DISTURBANCES of SUPERFICIAL REACTIVE UNIT
1. DISTURBANCES of EPIDERMIS
* DISTURBANCES of EPIDERMAL CELL KINETICS
* DISTURBANCES of EPIDERMAL CELL DIFFERENTIATION
* DISTURBANCES of EPIDERMAL COHESION
2. DISTURBANCES of DERMAL-EPIDERMAL COHESION
3. PATHOLOGIC REACTIONS of the ENTIRE SUPERFICIAL
REACTIVE UNIT
DISTURBANCES of EPIDERMAL CELL KINETICS
1. CELL PROLIFERATION THE GENERATIVE CELL PLATE >
EPIDERMAL CELL POPULATION
ELONGATION of the RETE RIDGES ( ACANTHOSIS )
2. CELL PROLIFERATION THE GENERATIVE CELL VOLUME <
FLATENING of the RETE RIDGES
EPIDERMIS BECOME THINNER ( ATROPHY )
3. PRODUCTION of CORNEOCYTES
DESQUAMATION of CORNEOCYTES

}
THICKENING of the STRATUM
CORNEUM
( HYPERKERATOSIS )
DISTURBANCES of
EPIDERMAL CELL DIFFERENTIATION
1. INCOMPLETE DIFFERENTIATION in POSTMITOTIC GERMINATIVE
CELLS / REDUCED TRANSIT TIME / DIRECT CELLULAR INJURY
RETENTION of PYKNOTIC NUCLEI in STRATUM CORNEUM
( PARAKERATOSIS )
2. DIRECT PHYSICAL / CHEMICAL / BIOLOGICAL INJURY
PREMATURE CORNIFICATION of INDIFIDUAL CELLS
( DYSKERATOSIS / apoptosis )
DISTURBANCES of EPIDERMAL COHESION
1. INFLUX of TISSUE FLUID INTO THE EPIDERMIS SPONGIOSIS
EDEMA INDIVIDUAL CELLS RUPTURE and LIZE
SPONGIOTIC VESICLES LARGE BLISTER
2. MIGRATION of LEUKOCYTES SPONGIFORM PUSTULE
3. TRAUMA DISSOLUTION of CELLS (CYTOLYSIS) BLISTERS
4. SEPARATION of the INTERDESMOSOMAL REGIONS
SPLITTING and DISAPPEARANCE of DESMOSOMES ( ACANTHOLYSIS )
INFLUX of FLUID from THE DERMIS
SUPRABASAL / MID EPIDERMAL / SUBCORNEAL CAVITATION
Acanthosis
Hyperkeratosis
Parakeratosis
dyskeratosis and acantholysis
Spongiform vesicle
Acantholysis
Pemphigus Vulgaris
Pemphigus vulgaris
Pemphigus Vulgaris
Herpes simplex infection
DISTURBANCES of DERMAL-EPIDERMAL COHESION
DESTRUCTION of the JUNCTION ZONE SUBEPIDERMAL BLISTER
( by Light Microscope )
PATHOGENESIS :
- Auto-Ab Specific Ag on the CYTOMEMBRANE of BASAL CELLS
(JUNCTIONAL BLISTERING)
- INFLAMMATORY PROCESS on the ENTIRE JUNCTION ZONE
( Auto-Ab type VII COLLAGEN / PHYSICAL / CHEMICAL CHANGES )
SUBEPIDERMAL / DERMOLYTIC BLISTERING
Bullous Pemphigoid
Bullous Pemphigoid
Epidermolysis bullosa
Epidermolysis bullosa
PATHOLOGIC REACTIONS of the ENTIRE SRU
MOST PATHOLOGIC REACTIONS of the SUPERFICIAL SKIN
INVOLVE > 1 SUB UNITS of the SRU JOINTLY (incld. Papillary body)
CLINICAL PICTURES DEPEND ON THE PROMINENCE of
INVOLVEMENT
* A FEW SKIN DISEASES ARE EXAMPLES :
contact dermatitis
psoriasis
interface dermatitis
erythema multiforme
lupus erythematosus
lichen planus
dermatitis herpetiformis