Zhao Mingyao
BMC.ZZU
2006-3-20
• I cannot and should not be cured of
by stress, but merely taught to enjoy
it.
-- Hans Selye
Hans Selye 1909~1982
Stress
General Adaptation Syndrome
• Experiment found :
• ?
• ?
• ?
STRESS MODEL
BLACK
BOX RESPONSE CONSEQUENCES
WELLNESS
?
FLIGHT
STRESSOR FIGHT
ADAPT ILLNESS
stress in medicine ?
protect effect
Non-specific response
harmful effect
Stress
Pathologica
l status
Physiological
status
New Pathological status
when against pathological process
Stress
wide meaning in medicine
physiological & pathological
somatical & schycological
eustress & distress
narrow meaning here
somatical & pathological & distress
Stress around us
Exam now
Tour now
⑶ Other hormones
⑷ AP ( Acute phase protein )
⑸ HSP( Heat shock protein, stress protein )
①Cardiovascular function
②hypermetabolism: glycogenolysis
③respiration
④promoting secretion of other hormone
2)Peripheral detrimental effects :
Central: ?
Peripheral: interact with adrenaline to affect, blood flow,
cardiac output, respiration
① blood glucose↑
②promote catecholamine and glucagon to
activate fat
③maintain response of circulatory system to CA
④stabolize lysosomal membrane: inhibits PLA 2
Cortisol
• Energy Mobilization
• Immune System Regulation
3. effects of Other hormones
during stress
Central
Peripheral
Section 3 Cellular and humoral
response
1. Acute phase protein
positive
negative
AP origin : comes from
7 subfamilies
Conserved
Little quantity
Drosophila
HSP70
molecular chaperone
• Heat shock proteins
(HSPs) play essential
roles in protein folding
and membrane
translocation.
Section 4 functional an d
metabolic response
Total tendency