Benign and malignant breast disorders are common in Libyan

women particularly among younger individuals when compared

to the western counterparts. As per the Benghazi cancer
registry, 26% of all the cancers among the Libyan women are
breast cancers. The present study is to compare the serum
levels of Follicular stimulating hormone, luteinizing hormone
and prolactin in benign and malignant disorders of breast.
Introduction
A total of 12 cases of carcinoma of breast patients in the age
group 30 55 years of age; 10 cases of fibroadenosis in the
age group 18 to 50 years were selected from department of
surgery, 7
th
October Hospital, Benghazi, Libya. Similarly 12 age
matched controls free from both malignant and benign
disorders of breast were included in this study. Venous blood
samples were collected from all the patients and controls and
estimation of serum follicular stimulating hormone, luteinizing
hormone and prolactin levels were estimated by using
appropriate kits with Cobas E411 analyser. Statistical analysis
was done using SPSS software using Mann-Whitney and
Wilcoxon tests.
.

The relationship between pituitary hormones and breast cancer
risk is shown here by a significant raise in prolactin level and
although the anterior pituitary is the major source of prolactin,
the hormone is synthesized and secreted in many other tissues
such as the human breast cancer cells as shown by many
tissue culture studies and further follow-up studies are required.

Conclusion
Materials and methods
Results
References
FSH and LH were not significantly elevated in carcinoma breast
(p= 0.136 & 0.619) when compared with controls. FSH and LH
levels in patients with benign disorders also did not show
significance when compared with controls (p=0.266 & 0.336).
However, Serum prolactin was significantly elevated in patients
with carcinoma breast when compared with controls (p=0.016)
as well as with cases of fibroadenosis (p=0.017). Results are
summarized table .1,2 and 3
Serum FSH, LH and Prolactin levels in Benign and Malignant Breast Disorders in
Libyan women.
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1
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S. Shakila
1
, J. R. Peela
1
,A. R. Said
1
, H. Beloch
2
, S. Nang
2
, L. T. Peela
3
, A. M. Jarari
4
, S. O. Alsaeoti
5
, H. El Awamy
4
, F. Elshaari
4
, N. M. Jarari
6
, M. J. Kadeer
4
.

1.Department of Biochemistry, Faculty of Medicine,Quest International University Perak, Ipoh, Malaysia,
2.Department of Community Medicine,Faculty of Medicine,Quest International University Perak, Ipoh, Malaysia,
3.Great Eastern Medical School, Srikakulam, India,
4.Department of Biochemistry, Faculty of Medicine,University of Benghazi, Benghazi, Libya.
5.Department of Surgery, Faculty of Medicine,University of Benghazi, Benghazi, Libya.
6.Department of Pharmacology, Faculty of Medicine,University of Benghazi, Benghazi, Libya.

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FSH

LH

PRL
No of cases 12 12 12
Mean 55.44 28.52 207.81
Std. Error of Mean 14.47 8.88 66.53
Std. Deviation 50.12 30.78 230.47


FSH

LH

PRL
No of cases 10 10 10
Mean 22.41 25.73 860.83**
Std. Error of Mean 15.72 10.25 518.61
Std. Deviation 41.60 29.00 1466.87


FSH

LH

PRL
No of cases 12 12 12
Mean 8.62 9.63 267.64
Std. Error of Mean 3.03 2.46 24.87
Std. Deviation 9.08 7.40 74.62
Table.1 Mean and standard values of carcinoma breast. FSH: Follicular
Stimulating hormone,LH: Luteinizing hormone and PRL: Prolactin
** Statistically significant ( p-Value < 0.05)
Table.3 Mean and standard deviation values of Fibroadenosis. FSH: Follicular
Stimulating hormone,LH: Luteinizing hormone and PRL: Prolactin.
.
Table.2 Mean and standard values of Controls. FSH: Follicular Stimulating
hormone,LH: Luteinizing hormone and PRL: Prolactin.