Docente: Dr. Carlos Lizrraga Stucci Adiccin. Definicin RAE Hbito de quien se deja dominar por el uso de alguna o algunas drogas txicas, o por la aficin desmedida a ciertos juegos DEPENDENCIA VS IMPULSIVIDAD VS COMPULSIVIDAD CARACTERSTICA DE LAS ADICCIONES CONDUCTUALES 1. Conducta anormal en un perodo de 1 ao. 2. Prdida del control al inicio de la conducta. 3. Efecto de recompensa. 4. Desarrollo de tolerancia. 5. Cambio de la percepcin de la conducta. 6. Impulsividad y deseo de ejecutar la conducta. 7. Funcin de la adiccin para regular el humor. 8. Expectativa del efecto. 9. Patrn limitado de la conducta. 10. Ocupacin cognitiva en la realizacin de la conducta. 11. Percepcin distorsionada e irracional de diferentes aspectos de la conducta. 12. Sndrome de retirada. 13. Continuacin de la conducta a pesar de los efectos negativos. 14. Reacciones aprendidas/condicionadas. 15. Sufrimiento.
F63 Trastornos de los hbitos y de los impulsos Esta categora abarca ciertos trastornos de la conducta que no son clasificables bajo otros cdigos. Consisten en acciones iterativas que no tienen una clara motivacin racional, que no pueden ser controladas y que generalmente atentan contra los propios intereses de la persona o los de otras. El paciente suele indicar que esta conducta se asocia con impulsos para la accin. La causa de estos trastornos no ha sido dilucidada y se los agrupa debido a sus amplias similitudes descriptivas y no porque se sepa que compartan alguna otra caracterstica importante entre s.
F63.0 Juego patolgico (ludomana) Y en el DSM V? In psychiatry, the only disorders that have been considered addictions are those involving alcohol or other drugs. Now, proposed revisions for the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders include for the first time "behavioral addictions"a change some say is long overdue and others say is still premature. So far, only one behavior has made the cut: gambling, which under the new proposal would join substance-use disorders as a full-fledged addiction. Y en el DSM V? In addition to the substance-related disorders, this chapter also includes gambling disorder, reflecting evidence that gambling behaviors activate reward systems similar to those activated by drugs of abuse and produce some behavioral symptoms that appear comparable to those produced by the substance use disorders. Other excessive behavioral patterns, such as Internet gaming, have also been described, but the research on these and other behavioral syndromes is less clear. Thus, groups of repetitive behaviors, which some term behavioral addictions, with such subcategories as "sex addiction", "exercise addiction, or "shopping addiction, are not included because at this time there is insufficient peer-reviewed evidence to establish the diagnostic criteria and course descriptions needed to identify these behaviors as mental disorders. ADICCIN AL JUEGO (LUDOPATA) ADICCIN AL INTERNET 5 criterios The DAT images of the bilateral corpus striatum in the control group showed a panda-eye shape and DATs were distributed uniformly and symmetrically in the corpus striatum. The DAT images of the IAD subjects displayed different levels of abnormity, in which the corpus stratums were much smaller and showed different shapes, dumbbell, thin strip, lunate shape, or sporadic spot. ADICCIN AL SEXO ADICCIN AL SEXO ADICCIN A LOS EJERCICIOS ADICCIN A LAS COMPRAS FACTORES DE RIESGO No existe una personalidad pre mrbida del adicto . Individuals with behavioral addictions and those with substance use disorders both score high on self-report measures of impulsivity and sensation-seeking and generally low on measures of harm avoidance (1620). However, individuals with some behavioral addictions, such as internet addiction or pathological gambling, may also report high levels of harm avoidance (21; see also Weinstein and Lejoyeux, this issue). Other research has suggested that aspects of psychoticism, interpersonal conflict, and self-directedness may all play a role in internet addiction (see Weinstein and Lejoyeux, this issue). In contrast, individuals with obsessive compulsive disorder generally score high on measures of harm avoidance and low on impulsivity (17,21). Individuals with behavioral addictions also score high on measures of compulsivity, but these may be limited to impaired control over mental activities and worries about losing control over motor behaviors (22). Impaired inhibition of motor responses (impulsivity) has been found in individuals with obsessive compulsive disorder and pathologic skin picking (a behavioral addiction with arguably closer phenomenological links to obsessive compulsive disorder), whereas cognitive inflexibility (thought to contribute to compulsivity) was limited to obsessive compulsivity disorder (23,24). FACTORES DE RIESGO Sin embargo, existir un genotipo pre mrbido? Due to the lack of genetic studies on compulsive buying, compulsive sexual behavior and compulsive computer use, it is early to speculate whether genetic findings in these behavioral addictions would be similar to the findings on pathological gambling. FISIOPATOLOGA The Dopamine Reinforcement Pathway MS NEUROTRASMISORES Noradrenalina: Arousal y excitacin, elevada. Serotonina: Iniciacin del comportamiento (modulador del impulso) y cese. Disminuida. Dopamina: Recompensa y refuerzo, resultados ambiguos. Opiodes: Placer y urgencia. Elevados? Tx con naltrexona. Glutamato: Procesos motivacionales. Excitador. Disminuidos? Tx glutamatrgico en PG. Primero la adiccin y despus el dao cerebral o viceversa? BACKGROUND: Gambling is a form of nonsubstance addiction classified as an impulse control disorder. Pathologic gamblers are considered healthy with respect to their cognitive status. Lesions of the frontolimbic systems, mostly of the right hemisphere, are associated with addictive behavior. Because gamblers are not regarded as "brain-lesioned" and gambling is nontoxic, gambling is a model to test whether addicted "healthy" people are relatively impaired in frontolimbic neuropsychological functions. METHODS: Twenty-one nonsubstance dependent gamblers and nineteen healthy subjects underwent a behavioral neurologic interview centered on incidence, origin, and symptoms of possible brain damage, a neuropsychological examination, and an electroencephalogram. RESULTS: Seventeen gamblers (81%) had a positive medical history for brain damage (mainly traumatic head injury, pre- or perinatal complications). The gamblers, compared with the controls, were significantly more impaired in concentration, memory, and executive functions, and evidenced a higher prevalence of non-right-handedness (43%) and, non-left-hemisphere language dominance (52%). Electroencephalogram (EEG) revealed dysfunctional activity in 65% of the gamblers, compared with 26% of controls. CONCLUSIONS: This study shows that the "healthy" gamblers are indeed brain-damaged. Compared with a matched control population, pathologic gamblers evidenced more brain injuries, more fronto-temporo-limbic neuropsychological dysfunctions and more EEG abnormalities. The authors thus conjecture that addictive gambling may be a consequence of brain damage, especially of the frontolimbic systems, a finding that may well have medicolegal consequences. Abstract INTRODUCTION: In Parkinson's disease, the degeneration of the dopaminergic system and the longstanding exposure to dopamine replacement therapy (DRT) may cause, in a group of vulnerable patients, dysregulation of the brain reward system. STATE OF THE ARTS: These patients develop DRT-related compulsions, which include addiction to levodopa or dopamine dysregulation syndrome (DDS), punding, and impulse control disorders (ICDs). ICDs or behavioral addiction reported in Parkinson's disease include pathological gambling, hypersexuality, compulsive buying and binge eating. Although the underlying pathophysiology is still poorly understood, these behaviors are linked by their reward-based and repetitive nature. Such behaviors may result in devastating psychosocial impairment for the patients and are often hidden. PERSPECTIVE AND CONCLUSIONS: The recognition of these behaviors is important and allows a better clinical management. Although the limited data do not permit particular therapeutic strategies, some approaches are worth considering: DRT reduction, trials of non- dopaminergic medications and subthalamic chronic stimulation.
TRATAMIENTO RECOMENDACIONES AUSTRALIA Terapia de grupo deberan ser utilizados en reducir la severidad del juego patolgico en personas slo con dicha enfermedad (B). Antidepresivos no deberan ser utilizados en reducir la severidad del juego patolgico en personas slo con dicha enfermedad (B). Naltrexona puede ser utilizado en reducir la severidad del juego patolgico (C). Estabilizadores del nimo/anticonvulsivantes, N- acetilcistena y olanzapina: se recomienda investigando con ECR.
RECOMENDACIONES SINGAPUR Terapia de grupo deberan ser utilizados en reducir la severidad del juego patolgico en personas slo con dicha enfermedad (B). Fluvoxamina y paroxetina podran ser considerados en reducir la severidad del juego patolgico (B). Naltrexona puede ser utilizado en reducir la severidad del juego patolgico (A).