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Anggota :

Rosalia Suryaningtyas 108114162


Marcelina Widani A R 108114163
Elizabeth Sita 108114165
Naomita Joice 108114168
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Pulsatile Drug Delivery System
(PDDS) didefinisikan sebagai
suatu sistem penghantaran
obat dengan pelepasan obat
pada waktu yang tepat dan
dalam dosis yang tepat.
Sistem pelepasan ini
umumnya didasarkan pada
irama sirkadian pada tubuh
Kontol pelepasan PDDS dapat
berupa kontrol terhadap
waktu, kontrol terhadap
tempat pelepasan atau
kombinasi dari keduanya.

(Raghavendra Rao et. aL., 2013) only for study purposes
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Tujuan dibuatnya PDDS biasanya untuk mengatasi :
1. Chronopharmacotherapy of diseases which shows
circadian rhythms in their pathophysiology.
2. Avoiding the first pass metabolism e.g. protein and
peptides2
3. For which the tolerance is rapidly exists,
4. For targetting specific site in intestine e.g. colon,
5. For time programmed administration of hormone
and drugs,
6. For drugs having the short half life and their
mechanism.

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KELEBIHAN PDDS
Mengurangi efek samping
Mengurangi frekuensi
dosis
Mengurangi ukuran dosis
Meningkatkan kepatuhan
pasien
Mengurangi biaya harian
pasien karena unit dosis
yang dibutuhkan pasien
untuk terapi lebih sedikit
Obat menargetkan ke sisi
spesifik seperti kolon
Melindungi mukosa dari
obat yang mengiritasi
KELEMAHAN PDDS
Banyak proses yang
bervariasi
Tahap formulasi yang
banyak
Biaya produksi yang tinggi
Membutuhkan teknologi
maju
Membutuhkan orang
terlatih/berkemampuan
untuk produksi
By Sagar Vekariya, Parul K. Patel, Rishad
Jivani, 2011
By Saikrishna Reddy Chinnavontari, 2012
4
(Raghavendra Rao et. aL., 2013) Only for study purpose

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(Chandani et. aL., 2012) Only for study purpose

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(Jain et. aL., 2011) Only for study purpose
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Critical
Factors
1.
Temperature
2. PH
3. Enzym
4. Osmotic
Pressure
5. Type of
polymer
6. polymers
thickness
Type of plug
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1.Time controlled delivery system
a. Rupturable coating layer
b. Erodible coating layer
c. Capsule shaped system provided with
release controlling plug

2. Stimuli or Site Specific Delivery Systems
a. Temperatur induced system
b. Chemical stimuli induced pulsatile system

3. Externally regulated systems


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Only for study
purpose
Source : Ritika, S., et al., 2012, Pulsatile Drug Delivery System: A Review,
International Reaserah Journal of Pharmacy

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Source : http://www.pharmatutor.org/articles/pulsatile-drug-delivery-system-a-review?page=0,2
Only for study
purpose
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Only for study
purpose
Source : http://www.slideshare.net/optimpharma/pulsatile-drug-delivery-system
13
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Only for study
purpose
Source: http://www.pharmainfo.net/reviews/osmotic-drug-
delivery-update
15
(Satinder et. aL., 2013) Only for study purpose

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Source : Ritika, S., et al., 2012, Pulsatile Drug Delivery System: A Review,
International Reaserah Journal of Pharmacy, only for study purpose
17
Only for study
purpose
Source : http://www.empr.com/tikosyn/drug/256/
http://www.business-review-webinars.com/pdf/presentation/Aptalis_Webinar_Formulation_Design_for_Max_Drug_Performance_060811.pdf
http://www.erowid.org/pharms/show_image.php?i=oxymorphone/oxymorphone_tablet__i2008e1035_disp.jpg

Pulsincap
TM
technology
Diffucaps

Opana
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