Inversia chirala la R-ibuprofen

Eliminarea

Chloramine-T ,Cloramina T

Tosylchloramide is an antiseptic/disinfectant,
often used as the sodium salt tosylchloramide
sodium. It is available under the brand name
Disifin.

Hidantoine dactin, dibromantin, BCDMH

Some N-Halogenated derivatives of hydantoin are used

as chlorinating or brominating agents in
disinfectant/sanitizer or biocide products. The three
major N-halogenated derivatives are
dichlorodimethylhydantoin (DCDMH),
bromochlorodimethylhydantoin (BCDMH), and
dibromodimethylhydantoin (DBDMH)

Iodoform

Formaldehyde, Glutaraldehyde

Acid salicilic

Faringosept

Quaternary Ammonium Compounds

Also known as Quats or QAC's, include the chemicals

benzalkonium chloride (BAC), benzethonium chloride
(BZT) and
Benzalkonium chloride is used in some pre-operative
skin disinfectants (conc. 0.050.5%) and antiseptic
towels.

Derivati de acridina

Ethacridine lactate (ethacridine monolactate

monohydrate, acrinol, trade name Rivanol) is an
aromatic organic compound based on acridine. Its formal
name is 2-ethoxy-6,9-diaminoacridine monolactate
monohydrate. It forms orange-yellow crystals with a
melting point of 226 C and it has a stinging smell.

Quinoline oxichinol, cliochinol,

saprosan,decalina

Prima Sulfamida Prontozilul rosu

prodrug

Sulfonamide drugs were the first antimicrobial drugs, and paved the way for
the antibiotic revolution in medicine. The first sulfonamide was trade named
Prontosil, which is a prodrug
Sulfonamidochrysoidine (KI-730), first synthesized by Bayer chemists Josef
Klarer and Fritz Mietzsch, was tested and found effective against some
important bacterial infections in mice by Gerhard Domagk, who
subsequently received the 1939 Nobel Prize in Medicine. Prontosil was the
result of five years of research and testing involving thousands of
compounds related to azo dyes.

Sulfanilamida

Jacques and Thrse Trefouel and their team at the French Pasteur
Institute found in 1936 that prontosil is metabolized to sulfanilamide
(para-aminophenylsulfonamide), a much simpler, colorless
molecule, redefining Prontosil as a prodrug. Prontylin became the
first oral version of sulfanilamide by Bayer.
Its synthesis had been first reported by Paul Gelmo, a chemistry
student working at the University of Vienna in his 1909 thesis, but he
had not realized its medical potential.

Short acting sulfonamide

Sulfisomidine (INN), also known as

sulphasomidine (BAN until 2003),[1]
sulfamethin and sulfaisodimidine, is
a sulfonamide antibacterial. It is
closely related to sulfadimidine.
(A British Approved Name (BAN) is
the official non-proprietary or generic
name given to a pharmaceutical
substance, as defined in the British
Pharmacopoeia (BP). The BAN is also
the official name used in many
countries across the world, especially
those of the Commonwealth of Nations
Sulfanilamida
Sulfaisodimidine Sulfamethizole
Sulfadimidine Sulfapyridine
Sulfafurazole Sulfanilamide
(Prontosil) Sulfathiazole
Sulfathiourea

Intermediate-acting sulfonamide

Sulfadiazina - Silver sulfadiazine is

a sulfa derivative[1] topical
antibacterial historically used as a
topical burn cream on second- and
third-degree burns
Sulfamethoxazole (abbreviated
SMX[1][2] and less reliably[3]
SMZ[4][5][6]) is a sulfonamide
bacteriostatic antibiotic. It is most often
used as part of a synergistic
combination with trimethoprim in a 5:1
ratio in co-trimoxazole (abbreviated
SXT, SMX-TMP and SMZ-TMP,[7] or
TMP-SMX and TMP-SMZ), also known
under trade names such as Bactrim,
Septrin, or Septra.
Sulfamethoxazole Sulfadiazine#
Sulfamoxole

Biseptol (400-50)

Sulfatiazol

Sulfametoxazol

Sulfamethoxazole (abbreviated SMX[1][2] and less reliably[3] SMZ[4][5][6]) is a

sulfonamide bacteriostatic antibiotic. It is most often used as part of a synergistic
combination with trimethoprim in a 5:1 ratio in co-trimoxazole (abbreviated SXT,
SMX-TMP and SMZ-TMP,[7] or TMP-SMX and TMP-SMZ), also known under trade
names such as Bactrim, Septrin, or Septra. Its primary activity is against susceptible
forms of Streptococcus, Staphylococcus aureus (including MRSA), Escherichia coli,
Haemophilus influenzae, and oral anaerobes. It is commonly used to treat urinary
tract infections. In addition can be used as an alternative to amoxicillin-based
antibiotics to treat sinusitis.

Trimetoprim

Trimethoprim was commonly (since1969 in the UK-GlaxoSmithKline )

used in a 1:5 combination with sulfamethoxazole, a sulfonamide
antibiotic, which inhibits an earlier step in the folate synthesis
pathway (see diagram above). This combination, also known as cotrimoxazole, TMP-sulfa, or TMP-SMX, results in an in vitro synergistic
antibacterial effect by inhibiting successive steps in folate synthesis.
This claimed benefit was not seen in general clinical use.[2] [3]

Antibiotice beta-lactamice
Penicillin, the first natural
antibiotic discovered by
Alexander Fleming in
1928.
In 1999, Time Magazine
named Fleming one of
the 100 Most Important
People of the 20th
Century for his discovery
of penicillin

Testing the susceptibility of Staphylococcus aureus to antibiotics by the

Kirby-Bauer disk diffusion method. Antibiotics diffuse out from
antibiotic-containing disks and inhibit growth of S. aureus resulting in a
zone of inhibition

Efitard

Moldamin

Ampicilina

Oxacilina

Cefalosporine

Cephalosporin compounds were first

isolated from cultures of Cephalosporium
acremonium from a sewer in Sardinia in
1948 by Italian scientist Giuseppe Brotzu [2].
He noticed that these cultures produced
substances that were effective against
Salmonella typhi, the cause of typhoid fever,
which had beta-lactamase. Guy Newton and
Edward Abraham at the Sir William Dunn
School of Pathology at the University of
Oxford isolated cephalosporin C. The
cephalosporin nucleus, 7aminocephalosporanic acid (7-ACA), was
derived from cephalosporin C and proved to
be analogous to the penicillin nucleus 6aminopenicillanic acid, but it was not
sufficiently potent for clinical use.
Modification of the 7-ACA side-chains
resulted in the development of useful
antibiotic agents, and the first agent
cephalothin (cefalotin) was launched by Eli
Lilly in 1964

 Aspirin (USAN), also known

as acetylsalicylicacid (abbrev
iated ASA), is a salicylate drug,
often used as
an analgesic to relieve minor
aches and pains, as an
antipyretic to reduce fever, and
as

an antiinflammatory medication
.
Aspirin was first isolated
by Felix Hoffmann, a chemist
with the German
company Bayer in 1897.[1][2]

(RS)-2-(4-(2-methylpropyl)phenyl)-propanoic acid

Ibuprofen (INN) (from iso-butyl- propanoic -phenolic acid) is a nonsteroidal

anti-inflammatory drug (NSAID) used for pain relief, fever reduction, and
against swelling.
Ibuprofen has an antiplatelet effect, though relatively mild and somewhat shortlived compared with aspirin or prescription antiplatelet drugs. In general,
ibuprofen also acts as a vasoconstrictor. Ibuprofen is a 'core' medicine in
the World Health Organization's Model List of Essential Medicines necessary to
meet the minimum medical needs of a basic healthcare system.
Ibuprofen was derived from propanoic acid by the research arm of Boots
Group during the 1960s and patented in 1961. Originally marketed as Brufen,
ibuprofen is available under a variety of popular trademarks, including
Motrin, Nurofen, Advil, and Nuprin. Generic formulations are available as well.
In Europe, Australia, and New Zealand, ibuprofen lysine (the lysine salt of
ibuprofen, sometimes called "ibuprofen lysinate" even though the lysine is
in cationic form) is licensed for treatment of the same conditions as ibuprofen.
The lysine salt increases water solubility

2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic
acid

Indometacin (INN) or indomethacin (USAN and

former BAN) is a non-steroidal anti-inflammatory
drug (NSAID) commonly used as a prescription
medication to reduce fever, pain, stiffness, and swelling. It
works by inhibiting the production of prostaglandins,
molecules known to cause these symptoms. It is marketed
under more than seventy different trade names.
Indomethacin was discovered in 1963 and it was first
approved for use in the U.S. by the Food and Drug
Administration in 1965. Its mechanism of action, along with
several other NSAIDs that inhibit COX, was described in
1971.

Diclofenac (INN ) is a nonsteroidal

anti-inflammatory drug (NSAID) taken
to reduce inflammation and as
an analgesic reducing pain in certain
conditions.
The name is derived from its
chemical name: 2-(2,6dichloranilino) phenylacetic acid.
In the United Kingdom, India, Brazil,
and the United States, it may be
supplied as either the sodium or
potassium salt, in China most often
as the sodium salt, while in some
other countries only as the potassium
salt. Diclofenac is available as a
generic drug in a number of
formulations, including
diclofenac diethylamine applied
topically. Over-the-counter (OTC) use
is approved in some countries for
minor aches and pains and fever
associated with common infections.

 Piroxicam is a non-steroidal anti-inflammatory drug of

the oxicam class used to relieve the symptoms of
rheumatoid and osteoarthritis, primary dysmenorrhoea,
postoperative pain; and act as an analgesic, especially where there
is an inflammatory component. It is manufactured by Pfizer under
the tradename Feldene, and is available in the UK, Spain, Portugal,
Belgium, Australia, Italy, Brazil and the United States. It is also
manufactured by Bosnalijek under the tradename Roxam, and is
available in Eastern Europe, Africa, and the Middle East. In India, it
is available by the tradename Dolonex. In Thailand it is available by
the tradename Fasden. It is manufactured as a patch by SK
Chemicals Co., Ltd. in Korea (www.skchemicals.com.cn) for use in
China under the trade name "Trast"; the Chinese name (in Pinyin) is
Biluoxikang Tiepian".
It is also used in veterinary medicine to treat
certain neoplasias expressing cyclooxygenase (COX) receptors,
such as bladder, colon, and prostate cancers.
Other brand names for Piroxicam include "Arantil", "Brexidol",
"Brexin", "Erazon", "Exipan", "Faxiden", "Felden", "Feldoral",
"Flamexin", "Hawksone", "Hotemin", "Lubor", "Mobilis", "Pirox von
ct", "Proponol", "Reumador", "Remox", "Roxam", "Sinartrol",
"Toricam", "Tracam", "Ugesic", "Veral" and "Vurdon".