ORLISTAT IN
TREATMENT OF
OBESITY
NOOR SHAIKH
K0520724
I Will Cover...
A Brief introduction to obesity
Treatments Available
Background on Orlistat
Mechanism of action
Clinics trials
Advantage of using Orlistat
Adverse effect
Conclusion
Obesity?
A condition associated with the accumulation of excessive
body fat, which leads to a reduction in quality of life
Obesity is measured by the BMI (body mass index)
measured by the relationship between the wieght and
hieght of an individual.
An individual to be considered obese their BMI would be
greater than 30 kg/m2
Obesity is a global issue. Obesity affects 24% of adults
(over 16) and 16% of children (2-16) in England.
[statistics taken in 2006]
Obesity are linked to other diseases, such as:
hypertension, diabetes, cardiovascular diseases etc..
These obesity linked diseases are costing the NHS a large
amount of money and a solution is need to solve the
Medical management of obesity
1. Chronic disease
•Serious health
cost
•Major risk factor
for common
causes of death
2. Multiple causes
•Genetic , hormonal
environmental ,
socio - economic ,
cultural
behavioural
•Patient shouldn ’ t be
3. Treatment options blamed for they
outcome of the
•Lifestyle disorder !
modifications
•Nutrition / diet
•Physical
activity
•Behaviour
modification
•Pharmacotherapy
•Surgery
Pharmacological treatment:
( Used in obese patient with BMI ≥ 27 kg / m 2)
o
oFirst generation Drugs – Most are
widthdrawn
-It was designed for long-term therapy
-mechanism of action appetite suppressants
-shown numbers of unpleasant effects such as:
valvular heart defects, addictive, safety problems
e.g fenfluramine