Place between page 60/61

B Cell Differentiation and Markers

/disrupted

ONLY!!

Clonal proliferation of a single stage

= good prognosis

=bad prognosis

Mature B Cells

T Cell marker
-not part of normal B Cell
>50 y.o.
Cells sequestered

B/t 60/61

T-Cell Differentiation and Markers

Sheets of immature cells with mitotic figures

T Cell acute lymphoblastic leukemia and T Cell acute lymphoblastic lymphoma

look very similar, have same symptoms, and can occur concurrently

Photophoresis is a last ditch effort

Pulls off buffy coat rich in T lymphocytes and downregulates themreinfuse into patients

Similar to mycosis fungoides, but more aggressive

Place between page 62/63

Morphology of Hodgkins Lymphoma

Place anywhere, most preferably between page 64/65

=Tissue Factor added

along with calcium

Sample placed in citrate tubecitrate binds calcium in blood, preventing clotting

-thromboplastin(tissue factor) is added along with Calcium, and clotting time noted

instead of thromboplastin (tissue factor)

Sample placed in citrate tubecitrate binds calcium in blood, preventing clotting

-kaolin or cephalin is added along with Calcium, and clotting time noted

CLINICAL PICTURE
EXCESSIVE BLEEDING
SPONTANEOUS BLEEDING
PLT CT < 20,000/ L
POST TRAUMATIC
PLT CT < 50,000/L
PETECHIAE, ECCHYMOSES, EPISTAXIS,
MUCOSAL BLEEDING, CNS
PLT CT, BT, NORMAL PT, PTT

 NON IMMUNOLOGIC DESTRUCTION

Subendothelial VWF

VWF has CF VIII and also receptor for GP1B of platelets

-platelets then attach to each other with fibrinogen linkage

I and II are invasive