Definition
Significance
Classification
Risk factors and prognostic factors
Presentation
Diagnosis
Management
Patient factors
Age
Gender
Genetic variants E.g. HLA pattern
Nutritional status
Pregnancy
Alcohol use
Concomitant drugs
Drug factors
Hepatic metabolism
Biliary excretion
Daily dose of drug - drugs given at a dose of >50 mg/d had the
highest risk of hepatotoxicity
Hepatocellular type
Cholestatic type
Other Ix
Cholestatic injury:
Pharmacological therapies
Supportive care
E.g. Relieve pruritus in cholestatic injury
Liver transplantation - an option in those who
progress to liver failure or biliary cirrhosis
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