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Pembimbing : Dr. Hj. Ratna M, Sp.

M
Oleh : Randy Rifianda
Kepaniteraan Klinik Stase Ilmu Penyakit Mata RSIJ Pondok Kopi
Program Studi Pendidikan Dokter Fakultas Kedokteran dan Kesehatan
Universitas Muhammadiyah Jakarta


Glaukoma

kerusakan saraf optik dan


kehilangan
lapang

pandang.
POAG
keluar
menyebabkan

pembendungan aliran
aqueous humor,
penimbunan


Beberapa studi

selenium yang berlebihan dalam


aqueous humor menyebabkan
penurunan adhesi sel trabecular
meshwork

Subjek

45 POAG

90 orang responden
45 Kontrol

Parameter

Jenis Kelamin
Usia
IMB
SBP

DBP
Smoking
IOP
Central corneal thickness


Serum dan selenium aqueous humor
Tingkat serum selenoprotein P1
Hemolysate GPx1 dan
tingkat penurunan
serum glutathione

GFAAS

ELISA

Teknik Colorimetri


Kriteria inklusi
POAG

Kriteria eksklusi
Glaukoma sekunder
Glaukoma kongenital
PACG
Calon trabeculectomy atau
fakoemulsifikasi

Statistik
Data dianalisis

SPSS 18.0

Student-t dan uji Chi Square


Nilai P kurang dari 0,05

signifikan.

Hasil penelitian

tingkat serum selenoprotein


P1 lebih tinggi dari 188 mg /
mL
tekanan intraokular lebih
tinggi dari 39 mmHg

Hasil ini
lainnya

harus

dikonfirmasi

cutoff poin dalam


skrining utama dari
POAG.

dalam

penelitian


Selenium dan tingkat
selenoprotein P1

berhubungan dengan
tekanan intraokular.

Serum P1 selenoprotein
dan tekanan intraokular

indikator yang lebih


sensitif untuk skrining
POAG.

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