Nerves,
Chapters 12
Seeleys
Anatomy & Physiology, 10th
edition by VanPutte, Regan and
Russo (McGraw Hill 2014)
Todays class
Enlargements
cervical: nerve fibers for upper limbs enter and
leave spinal cord
lumbosacral: nerve fibers for lower limbs enter
and leave the spinal cord
Brain
Level of foramen
magnum
Roots of spinal
nervesnerves
Spinal
purpose of enlargements?
Lumbosacral
enlargement
Level of second lumbar
vertebra
Spinal cord
Conus
medullaris
Cauda
equina
Filum
terminale
fig 12.1
Posterior view
Spinal meninges
Specialized membranes
Protection, stability, shock absorption
3 layers
dura mater thicker, superficial. Outside the
dura mater is the epidural space
arachnoid mater. The space between the
dura mater and arachnoid mater is the subdural
space and it contains cerebrospinal fluid.
pia mater. This layer is bound very tightly to
the spinal cord.
5
Meninge
al
membra
nes
surround
ing the
spinal
cord
Duramater
Subdural space
Denticulate ligament
Arachnoid mater
Subarachnoid space
Pia mater
Epineurium of spinal nerve
Dorsal root ganglion
Spinal nerve
Ventral root
Spinal cord
Denticulate
ligament
Spinal nerve
Ventral root
Body of vertebra
Pia mater
Subarachnoid space
Arachnoid mater
Subdural space
Periosteum
Epidural space filled with adipose
tissue
Dura
mater
Anterior
Spinal
anaesthesia
fig 12.4
10
11
Grey commissures
axons of interneurons crossing from one side of cord to
other
12
Central canal
White matter Dorsal
(posterior) column
Central canal
Lateral column
Gray matter
Posterior (dorsal)
horn
Lateral horn
Anterior (ventral)
horn
Spinal nerve
White matter
Dorsal (posterior)
column
Ventral (anterior)
column
Lateral column
Dorsal root
Ventral root
Gray commissure
Rootlets
White commissure
Anterior median fissure
(b)
Fig. 12.3
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Reflex Arc
3
Interneuron
Dorsal root
Dorsal root ganglion
2
Sensory neuron
1
Sensory
receptor
Spinal cord
Skin
4
Motor neuron
Spinal
nerve
Ventral root
5
1
Effector organ
Fig. 12.5
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Skeletal
muscle
Stretch reflex
Sudden stretch of a muscle results in:
From brain
To brain
3
2
Quadriceps
femoris muscle
(extensor)
Muscle
spindle
4
1
Sensory
neuron endings
Patellar
tendon
Hammer
tap
Gamma motor
neuron endings
Patellar
ligament
Hamstring
muscles
(flexor)
Fig. 12.6
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Alpha motor
neuron
Fig. 12.7
3
Sensory
neuron
Muscle contraction
increases tension
applied to tendons. In
response, action
potentials are conducted
to the spinal cord.
Sensory
neuron
Golgi
tendon
organ
Tendon
Inhibitory
interneuron
4
Alpha motor
neuron
Hamstring
muscles
(fexor)
Golgi
tendon
refex
Muscle
Fig. 12.7
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Withdrawal reflex
Stimulation of pain receptors results in:
To brain
Sensory neuron
Quadriceps
femoris
muscle
(extensor)
Excitatory
interneuron
Alpha motor
neuron
Hamstring
muscles
(fexor)
Sensory neuron
1
Stimulus
Pain receptor
Withdrawal reflex
Fig. 12.8
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Collateral branch
from sensory
neuron
Reciprocal innervation
1 During the withdrawal reflex,
sensory neurons conduct action
potentials from pain receptors to
the spinal cord.
Inhibitory
interneuron
Quadriceps femoris
muscle (extensor)
1
Hamstring
muscles
(flexor)
Sensory
neuron
To brain
Fig. 12.9
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Alpha motor
neuron
Excitatory
interneuron
muscle
(extensor)
Sensory
neuron
To brain
1
2
4
Alpha motor
neuron
3
Hamstring
muscles
(flexor)
Fig. 12.10
Alpha motor
neuron
Withdrawal
reflex
Excitatory
interneuron
Crossed
extensor
reflex
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
From
brain
Ascending
axon
Ascending
tract
Descending
axon
Site of
divergence
Sensory
receptor
Descending
tract
Sensory neuron
Site of
convergence
Skin
Motor neuron
Interneuron
Effector organ
Fig. 12.11
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Skeletal
muscle
Fasciculi (tracts)
Ascending tracts
Carry incoming information (sensory etc)
Descending tracts
Carry out-coming information (motor etc)
Structure of a
nerve
Adipose tissue
Epineurium
Perineurium
Endoneurium
Schwann
cell
fig 12.12
Fascicle
Axon
22
Cervical
nerves
Thoracic
nerves
C1
2
3
4
5
6
7
8
T1
2
3
4
5
6
7
8
9
Cervical
plexus
(C1C4)
Brachial
plexus
(C5T1)
Spinal
Nerves
and
plexuses
Duramater
10
11
12
L1
Lumbar
nerves
Cauda equina
Lumbar
plexus
(L1L4)
2
3
4
5
S1
S2
S3
S4
S5
Sacral
nerves
Coccygeal
nerves
Co
Fig. 12.13
Posterior view
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Sacral
plexus
(L4S4)
Coccygeal
plexus
(S5Co)
Lumbosacral
plexus
(L1S4)
Fig. 12.14
Cervical
nerves
C1
2
3
4
5
6
7
8
T1
C2
Head movement
Diaphragm
movement
C3
C2
T1
C6
C7
5
7
8
9
T2
T3
T4
T5
T6
T7
T8
T9
C5
Thoracic
nerves
Rib movement
inbreathing,
vertebral column
movement, and
tone in postural
back muscles
C5
C8
T2
T1
C6
T10
T11
T12
T1
C7
C5
T1
S2
L2
S5
Co
S3
C6
S4
L2
S3
L2
C7
L3
L3
L3
12
Lumbar
nerves
T2
C8
S4
L2
C6
T1
S3
11
T1
C6
C8
L1
10
L1
T3
T4
T5
T6
T7
T8
T9
T10
T11
T12
L1
C4
C4
2
3
C4
C3
S2
S2
Hip movement
L4
L4
L4
L4
L5
3
4
5
Lower limb
movement
S1
L5
S1
S1
L5
L5
L5
S1
S1
Sacral
nerves
Coccygeal
nerves
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
C7
C8
5 major Plexuses
Networks of nerves
combined ventral rami of adjacent spinal nerves
Form during development alongside muscle development
Plexuses:
organization produced by intermingling of nerves
Plexuses produce nerves with axons from more than one
spinal nerve.
Ventral rami of C1-C4 form the cervical plexus
C5-T1 form the brachial plexus
L1-L4 forms the lumbar plexus
L4-S4 forms the sacral plexus
S5 and the coccygeal nerve from the sacral plexus
Spinal
Dorsal root of
Spinalnerves
spinal nerve
nerves Dorsal root ganglion
Rootlets
Communicating rami
Ganglion of
sympathetic chain
Spinal nerve
Dorsal ramus of spinal
nerve
Ventral ramus of spinal nerve
Dont mix up
root and ramus!!
Ventral root of
spinal nerve
Roots of
Splanchnic nerve
Dorsal rootlets
Intervertebral foramen
Dorsal root ganglion
Spinal
nerve
fig 12.15
(b) Posterior view
26
Spinal nerves
31 pairs
all except first pair and those in the sacrum exit between the adjacent
vertebrae
8 in cervical region
12 in thoracic region
5 in lumbar
5 in sacral region
C0 below the sacral region
27
Cervical injuries can result the loss of use of both arms and legs or
quadraplegia
Thoracic injuries can result in loss of function of trunk and the legs
called paraplegia
The lumbar vertebrae injuries result in loss of function in hips and legs.
Good description of injuries (3.28 mins. from the Shepherd Centre)
http://www.youtube.com/watch?v=zxpb1-okVig&feature=related
Monkeys develop more use of injured arms
http://speakingofresearch.com/2014/05/19/spinal-cord-stimulation-restores-mo
nkeys-ability-to-move-paralysed-hand
/
New breakthrough in spinal cord regeneration called epidural stimulation.
http://
www.people.com/article/christopher-reeve-spinal-cord-injury-breakthrough
Human stem cell transplant from nasal epithelium that can partially reverse
spinal cord injury
http://speakingofresearch.com/2014/10/21/paralysed-man-walks-cell-transplant
/
Human exoskeletons
http://www.ted.com/talks/eythor_bender_demos_human_exoskeletons.html
Cervical plexus
C1
C4
Branches
Other nerves (not part
of cervical plexus)
C1
C5
Fig. 12.16
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Anterior view
Cervical plexus
Brachial
plexus
Posterior divisions
Cords: posterior, lateral, medial
Major branches:
Axillary nerve
Radial nerve
Musculocutaneous nerve
Median nerve
Ulnar nerve
T1
C5
Upper trunk
Middle trunk
Suprascapular nerve
Posterior cord
C7
Axillary nerve
Lateral cord
Radial nerve
Long thoracic nerve
C8
Lower trunk
Medial cord
Median nerve
Ulnar nerve
Medial brachial
cutaneous nerve
Fig.
12.17
Medial antebrachial
T1
cutaneous nerve
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Anterior view
Brachial plexus
Originates from C5-T1.
Five ventral rami join to form three trunks that separate into six
divisions and these join to form the posterior, lateral and medial
cords.
The five branches that innervate the upper limb originate from
the three cords.
The five major branches are:
1. The axillary nerves that innervates the shoulder
2. The radial nerve that innervates the posterior arm,
forearm and hand.
3. The musculocutaneous that innervates the anterior
hand
4. The unlnar that innervates the forearm
5. The medial nerves innervate the hand
Axillary nerve
Fig. 12.18
Axillary Nerve
Axillary nerve
Origin
Movements/Muscles Innervated
Laterally rotates arm
Teres minor
Posterior cord
Teres minor
Lateral cord
Medial cord
Deltoid
Abducts arm
Deltoid
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Posterior views
Fig. 12.19
Radial Nerve
Origin
Movements/Muscles Innervated
Extends elbow
Triceps brachii
Anconeus
Flexes elbow
Posterior cord
Lateral cord
Medial cord
Radial nerve
Lateral head of
triceps brachii
Long head of
triceps brachii
Medial head of
triceps brachii
Brachioradialis
Extensor carpi
radialis longus
Extensor carpi
radialisbrevis
Supinator
Extends fingers
Extensor digitorum
Extensor digiti minimi
Extensor indicis
Abducts thumb
Abductor pollicis longus
Extends thumb
Anconeus
Supinator
Extensor digitorum
Extensor digiti minimi
Extensor carpi ulnaris
Extensor indicis
Adductor pollicis
longus
Extensor pollicis
brevis and longus
Posterior view
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Posterior view
Anterior view
Musculocutaneous nerve
Fig. 12.20
Musculocutaneous Nerve
Origin
Posterior cord
Movements/Muscles Innervated
Flexes shoulder
Lateral cord
Musculocutaneous nerve
Medial cord
Biceps brachii
Coracobrachialis
Biceps brachii
Coracobrachialis
Flexes elbow
Brachialis
Anterior views
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Posterior view
Fig. 12.21
Ulnar Nerve
Origin
Posterior cord
Movements/Muscles Innervated
Lateral cord
Medial cord
Flexes fingers
Part of the flexor digitorum profundus
controlling the distal phalanges of little
and ring fingers
Ulnar nerve
Adducts thumb
Adductor pollicis
Anterior view
Posterior view
Adductor pollicis
Hypothenar muscles
The two medial
(ulnar) lumbricales
Anterior view
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Median Nerve
Origin
Posterior cord
Lateral cord
Medial cord
Movements/Muscles Innervated
Pronates forearm and hand
Pronator teres
Pronator quadratus
Median nerve
Flexes wrist
Palmaris longus
Flexes fingers
Anterior view
Palmaris longus
Pronator teres
Posterior view
Thenar muscles
The two lateral
(radial) lumbricales
Anterior view
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Fig. 12.22
L1
Lumbar
Fig. 12.23
and
sacral
plexus
L4
S4
L2
Iliohypogastric
Ilioinguinal
L3
Lateral femoral
cutaneous
L4
Genitofemoral
Femoral
L5
Obturator
Lumbosacral
trunk
S1
Superior gluteal
Inferior gluteal
Common
fibular
(peroneal)
S2
Tibial
S3
Sciatic
S4
Posterior femoral
cutaneous
S5
Pudendal
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Anterior view
1.
2.
3.
4.
Obturator Nerve
Fig. 12.24
L3
L4
Origin
Movements/Muscles Innervated
Rotates thigh laterally
Obturator externus
Obturator nerve
Adducts thigh
Adductor magnus (adductor part)
Adductor longus
Adductor brevis
Obturator externus
Gracilis
Adductor magnus
Adductor brevis
Adductor longus
Gracilis
Medial view
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Anterior view
Femoral Nerve
Fig. 12.25
L2
L3
L4
Origin
Movements/Muscles Innervated
Flexes hip
Psoas major
Iliacus
Pectineus
Extends knee
Vastus lateralis
Vastus intermedius
Vastus medialis
Psoas major
Iliacus
Femoral nerve
Sartorius
Pectineus
Vastus
lateralis
Rectus femoris
Vastus
intermedius
Vastus medialis
Anterior view
Tibial Nerve
Origin
Tibial nerve
L4
L5
S1
S2
Fig. 12.26
Lumbosacral plexus, L4S3
Movements/Muscles Innervated
Extends hip and flexes knee
Tibial nerve
S3
Adductor
magnus
Flexes knee
Popliteus
Flexes toes
Flexor digitorum longus
Flexor hallucis longus
Gastrocnemius
Popliteus
Soleus
Origin
Tibial nerve
Movements/Muscles Innervated
Flex and adduct toes
Plantar muscles of foot
Flexor hallucis
longus
Tibialis posterior
Movements/Muscles Innervated
None
Cutaneous (Sensory) Innervation
Lateral and posterior one-third
of leg and lateral side of foot
Anterior view
Posterior view
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Posterior view
Tibial nerve
Fig. 12.27
L4
L5
Common Fibular
(Peroneal) Nerve
S1
S2
Origin
Lumbosacral plexus, L4S2
Movements/Muscles Innervated
Extends hip and flexes knee
Biceps femoris (short head)
Common fibular
(peroneal) nerve
Deep Fibular
(Peroneal) Nerve
Biceps femoris
short head
Origin
Common fibular (peroneal) nerve
Movements/Muscles Innervated
Dorsiflexes foot
Tibialis anterior
Fibularis tertius
Tibialis anterior
Fibularis
longus
Extends toes
Extensor digitorum
longus
Fibularis
brevis
Extensor hallucis
longus
Fibularis
tertius
Origin
Common fibular (peroneal) nerve
Movements/Muscles Innervated
Plantar flexes and everts foot
Fibularis longus
Fibularis brevis
Cutaneous (Sensory) Innervation
Dorsal anterior third of leg and
dorsum of foot
Deep fibular
(peroneal) nerve
Superficial
fibular (peroneal)
nerve
Superficial Fibular
(Peroneal) Nerve
Extensor
digitorum
brevis
Anterior view
Lateral view
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Anterior view
Table 12.1
Next topic
The next topic is the Brain and
Cranial Nerves (Chapter 13)