Abira Rajasingam
Adrenal gland
Adrenal gland
Zona Glomerulosa
Renin-AAS pathway
RAA pathway
Stimuli that initiate the renin-angiotensin-aldosterone pathway include dehydration, Na+ deficiency, or
haemorrhage
These conditions cause a decrease in blood volume
Decreased blood volume leads to a decreased blood pressure
Lowered blood pressure stimulate certain cells of the kidneys, called juxtaglomerular cells, to secrete the enzyme
renin
The level of renin in the blood increases
Renin converts angiotensinogen into angiotensin I
Blood containing increased levels of Angiotensin I circulates in the body
ACE converts angiotensin I into the hormone angiotensin II
Blood level of angiotensin II increase
Angiotensin II stimulates the adrenal cortex to secrete aldosterone
Blood containing increased levels of aldosterone circulates to the kidney
Aldosterone increases reabsorption of Na+, which in turn causes reabsorption of water by osmosis. As a result, less
water is lost in the urine. Aldosterone stimulates the kidney to increase secretion of K+ and H+ into the urine
With increased water reabsorption by the kidneys, blood volume increases
As blood volume increases, blood pressure increases to normal
Angiotensin II also stimulate contraction of smooth muscle in the walls of arterioles. The resulting vasoconstriction
of the arterioles increases blood pressure and thus helps raise blood pressure to normal.
Besides angiotensin II, a second stimulator of aldosterone secretion is an increase in the K concentration of blood
(or interstitial fluid). A decrease in the blood K level has the opposite effect.
Zona Fasciculata
Glucocorticoids
Protein breakdown:
GCs increase the rate of protein breakdown- mainly in muscle fibersincreases the liberation of amino acids into the bloodstream.
Glucose formation:
Liver cells may convert certain amino acids or lactic acid to glucose,
which neurons and other cells can use for ATP production =
gluconeogenesis
Lipolysis:
Depression of immune response:
Given for organ transplant
Resistance to stress:
Additional glucose supplied by the liver cells provides tissues with a
ready source of ATP to combat a range of stresses, including exercise,
fasting, fright, temperature extremes, high altitude, bleeding,
infection, surgery, trauma, and disease
High doses can cause severe mental disturbances
Androgens
Adrenal medulla
Adrenal medulla
Epinephrine- 80%
Norepinephrine- 20%
Hormones of the adrenal medulla intensify sympathetic responses
that occurs in other parts of the body
In stressful situations and during exercise, impulses from the
hypothalamus stimulate sympathetic preganglionic neurons
stimulate the Chromaffin cells to secrete epinephrine and
norepinephrine.
By increasing heart rate and force of contraction, epinephrine and
norepinephrine increase the output of the heart, which increases
blood pressure.
They increase blood flow to the heart, liver, skeletal muscle, and
adipose tissue, dilate airways to the lungs; and increase blood levels
of glucose and fatty acids.
Blood supply
Blood supply
The adrenal glands and the thyroid gland are the organs that
have the greatest blood supply per gram of tissue.
Nerve supply