Dr.S.Manikandan
Department of Pharmacology
Jawaharlal Institute of Postgraduate Medical
Education and Research (JIPMER),
Pondicherry. INDIA.
Pathophysiology of Emesis
Cancer chemotherapy
Opioids
Chemoreceptor
Trigger Zone
(CTZ)
(Outside BBB)
Dopamine D2
5 HT3,,Opioid
Receptors
Cerebral cortex
Smell
Sight
Thought
Anticipatory emesis
Vomiting Centre
(medulla)
Muscarinic, 5 HT3 &
Histaminic H1
Motion
sickness
Vestibular
nuclei
Muscarinic
Histaminic H1
in hepatic insufficiency
Given once or twice daily orally or intravenously.
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Drugs Available
Ondansetron
32 mg / day
Granisetron
10 g / kg / day
Dolasetron
1.8 mg / kg / day
Indications
Chemotherapy induced nausea & vomiting given
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Adverse Effects
Excellent safety profile
Headache & constipation
All three drugs cause prolongation of QT interval,
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Dopamine D2 Antagonist
Antagonise D2 receptors in CTZ.
Drugs available
Metoclopramide
2.5 mg b.d
Domperidone
10 mg b.d
cannot.
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effects.
But as metoclopramide crosses BBB it has
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Prochlorperazine
Promethazine
Phenothiazines are antipsychotics with potent
Droperidol
Droperidol used for postop. nausea & vomiting,
H1 Antihistaminics
Most effective drugs for motion sickness
Drugs available
Meclizine
Cyclizine
Dimenhydrinate
Diphenydramine
Promethazine Used in pregnancy, used by
NASA for space motion sickness
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Anticholinergics
Scopolamine (hyoscine) used as transdermal
Cannabinoids
Dronabinol used as adjuvant in chemotherapy
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Explanation :
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Points to Ponder
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