TOXICOLOGY
PREPARED BY
SF DIPULA
LEARNING OBJECTIVES
At the end of this lecture students should be
able to:
Define terms
Discuss history of toxicology
Demonstrate understanding of different
poisons in Botswana
DEFINITION OF TERMS
Toxicology
Toxicant (poison)
The specific poisonous substance
Xenobiotic
Man made substance and/or produced by but not normally found in
the body
What is a poison????
DOSE
Dose Vs Poison
An apparently nontoxic
chemical can be toxic at
high doses. (Too much of
a good thing can be bad).
TERMS
Toxicity
The adverse effects that a chemical may
produce
Exposure
Contact providing opportunity of obtaining a
poisonous dose
Hazard
The likelihood that toxicity will be
expressed
POISONOUS SUBSTANCES
Produced by plants, animals, or bacteria.
Phytotoxins
PHYTOTOXINS
ZOOTOXINS
BACTERIOTOXINS
TERMS
Overdose
Risk
HISTORY
HISTORY
HISTORY
HISTORY
HISTORY
20th Century
Rachel Carson alarmed public about
dangers of pesticides in the environment
TYPES
Descriptive
Performs toxicity tests used to evaluate the risk that exposure to a
chemical poses to human beings & environment
Mechanistic
Determines how deleterious effects on living organisms
Regulatory
Judges whether or not a drug has a low enough risk to justify making it
available for its intended use
Forensic
Concerned with medicolegal aspects of chemicals
Clinical
Focuses on diseases that are caused by/are uniquely associated with
toxic substances
EPIDEMIOLOGY IN BOTSWANA
cleaning solutions
fuels
medicines, and other materials such as glue and cosmetics.
REFERENCES