Tips Umur Panjang

Growing Old Is Fairly New

When she died at the verified age of 122, Jeanne Calment (18751997) had lived longer than any other human on record.
AP/WIDE WORLD PHOTOS

Vividly colored fruits and vegetables such as these are rich in antioxidants. Although their role in the aging process is still unknown,
antioxidants are believed to reduce the risk of certain cancers.

Aging in Fast-Forward: Werner Syndrome

At age 15, this Japanese-American woman looked healthy, but by age 48, she had clearly developed symptoms of Werner
syndrome.
INTERNATIONAL REGISTRY OF WERNER SYNDROME

Definisi
Proses menua merupakan penimbunan secara
progresif dari semua perubahan yang terjadi
dengan bertambahnya waktu, dan berkaitan
dengan kerentanan terhadap penyakit,
kemudian kematian menyertai usia lanjut.
Prinsip: Proses menua adalah kehilangan daya
homeostesis/ daya pengembalian
keseimbangan dari gangguan infeksi, trauma,
stress dll.

Teori menua
1. Pengontrolan genetik (umur spesies)

2.
3.
4.
5.
6.

Redundan message (gen cadangan)

Aging gene (program genetik)

Rusak System Imun (rentan thd infeksi)

Mutasi somatik (Error katastrophe)
Radikal bebas
Ikatan silang makromolekul (kalogen)
Akibat metabolisme (intake kalori),
Kemunduran metabolism

Teori penuaan lainnya

Pakai dan Rusak

Neuro endokrin
Kontrol genetik
Telomerase
Radikal bebas
Cross-Linking teori

Teori Biologi menua lainnya

Telomere Theory
Telomeres (structures at the ends of chromosomes) have
experimentally been shown to shorten with each successive cell
division. Shortened telomeres activate a mechanism that prevents
further cell multiplication. This may be an important mechanism of
aging in tissues like bone marrow and the arterial lining where active
cell division is necessary.
Reproductive-Cell Cycle Theory
The idea that aging is regulated by reproductive hormones that act
in an antagonistic pleiotrophic manner via cell cycle signaling,
promoting growth and development early in life in order to achieve
reproduction, but later in life, in a futile attempt to maintain
reproduction, become dysregulated and drive senescence (dyosis).
Wear-and-Tear theory
The idea that changes associated with aging are the result of
chance damage that accumulates over time.

Teori Biologi menua lainnya

Somatic Mutation Theory
The biological theory that aging results from damage to the
genetic integrity of the bodys cells.
Error Accumulation Theory
The idea that aging results from chance events that gradually
damage the genetic code.
Accumulative-Waste Theory
The biological theory of aging that points to a buildup of cells
of waste products that presumably interferes with metabolism.
Autoimmune Theory
The idea that aging results from an increase in autoantibodies
that attack the body's tissues. A number of diseases
associated with aging, such as atrophic gastritis and
Hashimoto's thyroiditis, are probably autoimmune in this way.

Teori Biologi menua lainnya

Aging-Clock Theory
The theory that aging results from a preprogrammed sequence, as in a
clock, built into the operation of the nervous or endocrine system of the
body. In rapidly dividing cells the shortening of the telomeres would provide
just such a clock.
Cross-Linkage Theory
The idea that aging results from accumulation of cross-linked compounds
that interfere with normal cell function.
Free-Radical Theory
The idea that free radicals (unstable and highly reactive organic molecules,
also named reactive oxygen species or oxidative stress) create damage that
gives rise to symptoms we recognize as aging.
Mitohormesis
It has been known since the 1930s that restricting calories while maintaining
adequate amounts of other nutrients prevents aging across a broad range of
organism. Recently, Michael Ristow has shown that this delay of aging is
due to increased formation of free radicals within the mitochondria causing a
secondary induction of increased antioxidant defence capacity

Premature Aging
Penyakit generatif: hipertensi, penyakit
kardiovaskuler, diabetes yang terjangkit
pada umur setengah baya
Alzheimer
Huntington

Radikal Bebas
1. Sumber:
Penggunaan minyak makan yang berulang.
Polusi udara
Radiasi sinar UV.
2. Bentuk:
Superoksida (O2-),
radikal hidroksi (OH-) dan
hidrogen peroksida (H2O2)

Akibat RB pada sel

Terganggu transportasi sel

Gangguan membran sel
Menurun aktivitas enzim
Pembentukan pigmen ketuaan
Ikatan silang kolagen dan elastin
Pembentukan mukopolisakarida dalam
jaringan konective

Anti Oksidan (RB)

Provitamin A (beta karoten)

Vitamin C (As. Askorbat)
Vitamin E (tokopherol)
Flavonoid
Vitamin C& E menurunkan nafsu makan
Tetapi meningkatkan proses imun dan
resistensi & menurunkan perkembangan
tumor.

Anti Oksidan endogen

Enzim Superoksida dismutase (SOD)
Enzim Glutation Peroksidase (GSHPx)
Enzim katalase.

Penuaan dapat dicegah

Kecukupan dan keseimbangan nutrisi

Menjalani gaya hidup sehat
Terhindar dari radiasi sinar ultraviolet
Mengkonsumsi zat anti oksidan
Latihan fisik secara teratur
Mencegah, mengobati & rehabilitasi
penyakit generatif.

Biological Gerontology
Genetics
Biochemestry
Cell Biology
Genomics
Proteomics
Metabolomics
Demography
Evolution
Phisiology

Referensi

http://en.wikipedia.org/wiki/Biological_immortality"Categories: Aging