system
The DIGESTIVE SYSTEM
Alimentary tract composed of
organs, the primary function of
which is the ingestion, digestion and
absorption of nutrients
The DIGESTIVE SYSTEM
Oropharynx is a
passageway of both
food and air
The Esophagus
Function: to propel
food to the stomach
The Stomach
J-shaped dilatable part of the GIT
Located on the epigastric area
and right upper quadrant
With 3 parts:
1. Fundus
2. Body
3. Pylorus
Cells in the stomach
1. Mucus cells
2. Chief cells/principal
cells/Zymogenic cells
3. Parietal Cells
4. Argentaffin cells
Cells in the stomach
1. Mucus cells-
secrete mucus for
protection of the
mucosa
Cells in the stomach
2. Chief cells/principal
cells/Zymogenic cells
secrete Pepsinogen
needed for protein
digestion
Cells in the stomach
3. Parietal cells/Oxyntic
cells- secrete
Hydrochloric acid to
activate pepsinogen and
Intrinsic factor needed to
absorb Vitamin B12
Cells in the stomach
4. Argentaffin cells-
secrete Serotonin
Small intestine
Characteristics:
Provided with mesentery
Presence of villi
Presence of plicae circularis
Lined by simple columnar
Fig. 16.14
Parts of Small Intestine
Characteristics
Presence of haustra
Presence of taenia coli
Presence of appendices
epiploicae
Large intestine
Characteristics
No villi
With mesocolon on the
appendix, transverse
colon and sigmoid colon
Parts of the large
intestine
Cecum
Appendix
Ascending colon
Transverse colon
Descending colon
Sigmoid colon
rectum
Anus
Retroperitoneal organs
are found posterior to the
peritoneum- kidney,
pancreas, duodenum,
ascending and
descending colon, rectum
Mesentery
This is a peritoneum
folded upon itself
extending from the
organ to the abdominal
wall
Blood supply of the GIT
Pancreas
A pistol-shaped organ both
an endocrine and exocrine
gland
Parts: head, body and tail
Ducts: major is Wirsung,
minor is Santorini
Accessory organ
Liver
Largest internal organ
Located on the right upper
quadrant
With right and left lobes
Functions to secrete bile
Liv er p hy sio logy a nd
Pat ho ph ysiolo gy
Normal Function Abnormality in function
Mouth
Chewing or
mastication
Secretions
Mouth
Salivary secretions-
salivary amylase or ptyalin
begins the digestion of
carbohydrates
Movements
Mouth and esophagus: Deglutition
1. Voluntary phase- food bolus is
pushed by tongue to the pharynx
2. Pharyngeal phase- reflex action
3. Esophageal phase- peristaltic
waves moves the food towards the
stomach
Stomach movement
Mixing waves
Peristaltic
movements
Fig. 16.12
Secretions
Stomach
1. Mucus- by the mucus cells for
mucosal protection
2. HCL from parietal cells
3. Pepsinogen from chief cells
4. Intrinsic factor from parietal cells
5. Gastrin =a hormone from the antral G
cells
Secretions
Stomach
Digestion for lipids:
Gastric lipase
1. Bicarbonate- to
neutralize the acidic
chyme from the stomach
2. Pancreatic amylase- for
carbohydrate digestion
Pancreatic secretions
Eliminates wastes
Controls blood and fluid volume
Regulates acid-base balance
Regulates RBC production by
erythropoietin
The Kidney
Retroperitoneal organ surrounded
by capsule and fats
Right is lower than the left
The substance is composed of
renal cortex ( where nephrons are
located) and renal medulla
( where collecting ducts are
found)
The Nephron
Functional unit of the kidney that
produces urine by filtration
Composed of
Efferent arteriole
Glomerulus
Afferent arteriole
Bowman’s capsule
Convoluted tubules- proximal, loop of
Henle and distal
Special cells in the
nephron
Juxtaglomerular cells-
secrete renin and
erythropoietin
Podocytes
Blood supply of the
kidney
• Renal artery- branch of the
abdominal aorta
• Renal vein- drains into the
inferior venal cava
Renal pelvis
Funnel-shaped expanded portion
of the ureter
Formed by the calyces
Collects urine from the kidney
The Ureter
Left and right
A long slender tube that propels
urine from the kidney to the
urinary bladder
With smooth muscles and
transitional epithelium
With innervations from the
sympathetic and parasympathetic
The urinary bladder
Hollow pyramid shaped organ located
in the pelvis
Lined with transitional epithelium
With thick detrusor muscles
Micturition reflex resulting from the
distension of the organ
Impulses are transmitted to the sacral
parasympathetic segments to initiate
urination
Fig. 18.17
Urethra
Tube extending from the urinary bladder
to the external urethral orifice
1 ½ inches in females
3 parts in Males
1. Prostatic urethra- most dilatable
2. Membranous urethra- least dilatable and
shortest
3. Penile urethra- longest
Renal Physiology
Urine formation
1. Urinary blood flow
2. Glomerular filtration
3. Tubular reabsorption
4. tubular secretion
Fig. 18.12
Fig. 18.13
Fig. 18.14
End of renal
The MALE Reproductive
system
Made up of organs, ducts and
glands whose function is to
produce spermatozoa and
androgens
Internal Male
reproductive organs
1. Testes
2. Ducts- epididymis, vas deferens
and ejacularoty duct
3. Glands- prostate and Cowper’s
4. Seminal vesicle
The testes
Male gonad housed in the
scrotum
Divided into lobules containing
tubules and cells
Sperm cells are produced in the
seminiferous tubules
Leydig cells secrete testosterone
Spermatogenesis
Begins during puberty
Occurs in the seminiferous tubules
Spermatogonia divides by MITOSIS
into primary spermatocytes
Primary spermatocytes divide by
MEOSIS to produce secondary
spermatocytes
Spermiogenesis
Consists of 3 phases
• Menstrual phase
• Proliferative phase
• Secretory phase
OVARIAN cycle
Consists of three phases
1. Pre-ovulatory : follicular phase
2. Ovulatory phase
3. Post-ovulatory : Luteal phase
Uterine Cycle: Menstrual
phase
Day 1- day 5
First day of bleeding is the first
day of cycle
Stratum functionale (compactum
and spongiosum) is shed
Around 60 ml average!
Uterine cycle:
proliferative Phase
Day 5- day 14
Epithelial cells of functionale
multiply and form glands
Due to the influence of estrogen
Uterine cycle: Secretory
phase
Day 15- day 28
Endometrium becomes thicker and
glands secrete nutrients
Uterus is prepared for implantation
Due to progesterone
If no fertilization constriction
vessels menstruation
OVARIAN cycle
Consists of three phases
1. Pre-ovulatory : follicular phase
2. Ovulatory phase
3. Post-ovulatory : Luteal phase
Ovarian Cycle;
preovulatory/follicular
Variable in length: day 6- day 13
Dominant follicle matures and
becomes graafian follicle with
primary oocyte
FSH increases initially then
decreases because of estrogen
increase
Ovarian cycle: Ovulatory
phase
Day 14
Rupture of the graafian follicle
releasing the secondary oocyte
Due to the LH surge
MITTELSCHMERZ- pain during
rupture of follicle
OVARIAN cycle: Post-
ovulatory: luteal phase
Day 15- day 28
MOST CONSTANT 14 days after
ovulation
Corpus luteum secretes Progesterone
If no fertilization, corpus luteum will
become corpus albicans then
degenerate
Decreased estrogen and progesterone
Hormonal cycle
1. Menstrual phase
Decreased Estrogen, decreased
progesterone, decreased FSH and
decreased LH
2. Proliferative/ Pre-ovulatory phase
Increased FSH and Estrogen in
small amounts
Hormonal cycle
3. Ovulatory phase
Increased FSH, Increased LH
(surge) Increased Estrogen
4. Post ovulatory/luteal Phase
Increased Estrogen, increased
progesterone, decreased FSH
and LH
MENOPAUSE