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Course Code

MSE-338 [3-0]

Course Title

Biomaterials

Biomaterials: The Intersection of Biology and


Materials Science by J. S. Temenoff and A. G.
Mikos, 1st Edition, Pearson Education India, 2008.
Biomaterials: An Introduction by Joon Park and
R. S. Lake, 3rd Edition, Springer, 2007.

Dr. Saima Shabbir, MS&E, IST

Course Outline
Introduction to materials used in medicine, trace
elements in blood and their importance, surface
properties characterization of Bio materials,
surface & protein interactions, biological and
biochemical properties of proteins, cells & tissues,
biocompatibility & host reactions to bio implants,
implementation
&
degradation
of
implant
materials, sterilization and implants associated
infections, testing & bio materials surface coating,
elastomers, hydrogels and their applications.
Ceramics & bioglasses, adhesives & sealants,
degradable materials application in drug delivery.
Dr. Saima Shabbir, MS&E, IST

OBE
CLO #

CLO

PLO

Learning
domain and
level

Student will be able to discuss various classes of


CLO-1 biomaterials on the basis of structure and PLO-1
function.

C-2

Student will be able to explain the role of


CLO-2 adsorbed proteins in the tissue response to PLO-1
different kinds of biomaterials.

C-2

Student will be able to analyze events that lead


CLO-3 to the degradation of materials in the biological PLO-2
environment.

C-4

Student will be able to propose a biomaterial for


CLO-4 a specified application in drug delivery or PLO-3
implant material.

C-5

Dr. Saima Shabbir, MS&E, IST

Biomaterials
Module 1 PLO-1/CLO-1/C-2
Introduction

Dr. Saima Shabbir, MS&E, IST

What is a biomaterial?

Dr. Saima Shabbir, MS&E, IST

Definition: Biomaterial
Any material (other than a drug) of
natural or of synthetic origin that
comes in contact with tissue, blood or
biological fluids.
Intended for use in prosthetic,
diagnostic, therapeutic or storage
applications
without
adversely
affecting the living organism and its
components.
Dr. Saima Shabbir, MS&E, IST

Therapeutic Devices
in Orthopedics

Knee replacements
Dr. Saima Shabbir, MS&E, IST

Applications in Dentistry

Dr. Saima Shabbir, MS&E, IST

Catheters

Catheters allow drainage, injection of fluids, or


access by surgicalDr.instruments.
Saima Shabbir, MS&E, IST

In Ophthalomolgy

Dr. Saima Shabbir, MS&E, IST

In Drug Delivery

Dr. Saima Shabbir, MS&E, IST

Future ApplicationsTissue Replacement

Dr. Saima Shabbir, MS&E, IST

Implant
Any medical device, made from one
or more biomaterials, intentionally
placed within the body, either totally
or partially buried beneath an
epithelial surface, where it is
intended to remain for a significant
period.

Dr. Saima Shabbir, MS&E, IST

The Food and Drug


Administration
(www.fda.gov)

Regulates:
Food-Food borne Illness, Nutrition, Dietary
Supplements
Drugs-Prescription, Generic.
Medical Devices -Pacemakers, Contact
Lenses, Hearing Aids
Animal Feed and Drugs-Livestock, Pets
Cosmetics-Safety, Labeling..
Radiation Emitting Products-Cell Phones,
Lasers, Microwaves..
Dr. Saima Shabbir, MS&E, IST

Definition: Biomaterial -FDA


Find it..

Dr. Saima Shabbir, MS&E, IST

Drugs Control Organization,


Ministry of Health, Pakistan
(www.dcomoh.gov.pk/)

Responsible for regulating firms who


manufacture,
repackage,
relabel,
and/or import medical devices sold in
Pakistan.
Also regulates radiation emitting
electronic products (medical and nonmedical)
such
as
lasers,
X-ray
systems,
ultrasound
equipment,
microwave ovens and color televisions.
Dr. Saima Shabbir, MS&E, IST

Basics
A biomaterial
is a material used in a medical
device, intended to interact with
biological systems.1
is used to make devices to replace a
part of a function of the body in a
safe,
reliable,
economic,
and
physiologically acceptable manner.
Williams, D.F. (1987) Definitions in Biomaterials. Proceedings of a Consensus Conference of the European
Society For Biomaterials, England, 1986, Dr.
Elsevier,
New
York. MS&E, IST
Saima
Shabbir,
1

General Applications of
Biomaterials

Storage of fluids, tissues, and other


biological products
Diagnosis
Monitoring
Therapy

Dr. Saima Shabbir, MS&E, IST

Drugs Control Organization,


Ministry of Health, Pakistan
(www.dcomoh.gov.pk/)

Responsible for regulating firms who


manufacture,
repackage,
relabel,
and/or import medical devices sold in
Pakistan.
Also regulates radiation emitting
electronic products (medical and nonmedical)
such
as
lasers,
X-ray
systems,
ultrasound
equipment,
microwave ovens and color televisions.
Dr. Saima Shabbir, MS&E, IST

Relevant Websites
Biomaterials Network (www.biomat.net)
Medical
Device
Information
(www.devicelink.com)
Medical Materials Engineering reference
(www.engineeringreference.com)
United States Patents and Trademarks
Office (www.uspto.gov)
MEDLINE(www.ncbi.nih.gov/entrez/query.fcgi)
Dr. Saima Shabbir, MS&E, IST

Where can you find information


about medical devices?
www.nlm.nih.gov/services/meddevice.html
- Medical Device Link's Suppliers Page at
http://www.devicelink.com/company/
- MEDMarket Network's Internet Medical
Products Guide at
http://www.medmarket.com/index.cfm?
id=product_guide

Dr. Saima Shabbir, MS&E, IST