Pharmacology

• Prednisone (steroids;
corticosteroid
glucocorticoid)

– Uses inflammation,
hypercalcemia,
inherent steroid defx

– MOA – Inhibits or
activates transcription

Goodman, Louis, Alfred Gilman, Laurence

Brunton, John Lazo, and Keith Parker.
Goodman and Gilman. McGraw-Hill
Professional, 2006. Print
 Pharmacology
• Prednisone cont’d…
– SDFX Neuro, immune, endo, CV, e- balance,
Musculoskeletal, GI

– Absorption/Excretion metabolized in liver, excreted in urine

– C/I Guillain-Barré; DM

Goodman, Louis, Alfred Gilman, Laurence Brunton, John Lazo, and Keith Parker. Goodman
and Gilman. McGraw-Hill Professional, 2006. Print
 Pharmacology
• Hydroxychloroquine
(quinolone, anti-malarial)

– Uses – infections,
inflammation,
photosensitivity
diseases

– MOA antimalarial;
inhibits inflammatory
pathway

Goodman, Louis, Alfred Gilman, Laurence Brunton, John Lazo, and

Keith Parker. Goodman and Gilman. McGraw-Hill Professional,
2006. Print.
 Pharmacology
• Hydroxychloroquine cont’d…
– C/I – Epilepsy, MG, psoriasis, exfoliative skin dss, malarai +
porphyria cutanea tarda, mefloquine (↑%x szrs)

– Caution – GI/liver, neuro or blood problems, renal failure, G-

6-PD deficiency, amiodarone, digoxin

– SDFX – CV and CNS. GI, urticaria, vision disturbances,

pruitis, lechenoid skin eruptions, hair bleaching, hemolysis,
ototoxicity.
Goodman, Louis, Alfred Gilman, Laurence Brunton, John Lazo, and Keith Parker. Goodman
and Gilman. McGraw-Hill Professional, 2006. Print.