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MOLUSCUM CONTAGIOSUM

Presented by
Andi Geby N. Fonda C111 11 202
Ismail C111 11 337
Wilda Anggriani Ansar C111 11 378
RESIDENT:
dr. Evelyn

SUPERVISOR:
dr. Widya Widita, Sp.KK, M.Kes

DEPARTEMEN ILMU KESEHATAN KULIT - KELAMIN


FAKULTAS KEDOKTERAN
UNIVERSITAS HASANUDDIN
2016

INTRODUCTION
Molluscum Contagiosum often occurs on children
and young adult.
This disease causes papular and nodular lesion with
Molluscum body inside.
Molluscum Contagiosum is caused by Mollluscipox
genus virus which belongs to Poxviridae family.

DERMATOVENEREOLOGY DEPARTMENT OF MEDICAL FACULTY HASANUDDIN

DEFINITION
This disease is caused by virus belonging to Poxviridae
family and Molluscipox genus. The clinical lesion is
discrete papular with molluscum body inside.
This virus generally is only occurs on surface of the
skin and on mucous membrane.

ETIOLOGY
Molluscum Contagiosum
is caused by more than 4
Poxviridae viruses which
is connected such as MCV
I, MCV II, MCV III, and
MCV IV.

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Molluscum Contagiosum spreading:


1. Physical contact with a sufferer or
transmission from surrounding things.
2. Sexual contact usually occur on adults.
3. Can easily occur to people with immune
compromise.

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PATHOGENESIS
The virus replicates within the cytoplasm of
epithelial cells, and infected cells replicate at
twice baseline rate. There are MCV genes that
may contribute to an impaired immune response
to this virus including (1) homolog of a major
histocompatibiity class 1 heavy chain, which
may interfere with antigen presentation (2)
chemokine homolog that may inhibit
inflammation; and (3) a glutathione peroxide
homolog that may protect the virus from
oxidative damage by peroxides.

DERMATOVENEREOLOGY DEPARTMENT OF MEDICAL FACULTY HASANUDDIN

PATHOGENESIS
Virus
Moluscum
Contagiosu
m

Increasing of
proliferation
of the virus
inside the
cytoplasm of
epithelial cell

Growth of
epidermal
lobules

Molluscum
body
(diameter
25m )

Fibrous
septa
between
lobules

Inhibits
papilla

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DIAGNOSIS
1. Anamnesis
Usually asymptomatic, but sometimes can
be itchy and pain if theres inflammation
and infection.

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Clinical Findings:
Papul (can be a giant
molluscum, papul with much
bigger size)
Discrete
Surface as dome-like
Contain molluscum body

DERMATOVENEREOLOGY DEPARTMENT OF MEDICAL FACULTY HASANUDDIN

DERMATOVENEREOLOGY DEPARTMENT OF MEDICAL FACULTY HASANUDDIN

DERMATOVENEREOLOGY DEPARTMENT OF MEDICAL FACULTY HASANUDDIN

SUPPORTING EXAMINATION
Giemsa dye
Histopathology

DERMATOVENEREOLOGY DEPARTMENT OF MEDICAL FACULTY HASANUDDIN

Skin biopsy of Molluscum Contagiosum, shows downgrowth ofinfected


epidermal cells showing large eosinophilic cytiplasmic inclusion bodies

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PROGNOSIS
Patient will recover spontaniously, but
usually need a long time, for months until
years

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DIFFERENTIAL DIAGNOSIS
Verruccae Vulgaris : HPV infection on the epidermis with skin
lesion such as papul, dome-like skin-colored nodul, rough
surface with demarcated, can be singular or in group.

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Granuloma pyogeni : disease from capillary hemangioma. Has


lesions such as erythematous papul, quickly develop until the
size 1cm, easily bleed, have brunch, and solitary.

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Papular Granuloma Anulare: Small superficial papul which


develops from central umbilical or harden and sometimes has
secret as thick fluid. The lesion will leave atrophy scar or
hiperpigmentation.

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Kista Inklusi epidermid: subcutaneous nodul which is mobile


with black punctum in the center. This can be skin colored,
yellow, or white.

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Sebaceous Gland Hyperplasia: hyperplasia of the


sebaceous gland around infundibulum follicle,
solitary lesion or multiple small lesion sized 3
mm, yellowish, or telangiektasi papul meat-like
colored in the surface

DERMATOVENEREOLOGY DEPARTMENT OF MEDICAL FACULTY HASANUDDIN

THANK YOU