FRANTZ TUMOURS

EXPERIENCE FROM A TERTIARY CARE

CENTRE
KOYYODA PRASHANTH, SURESH KUMAR, ADITYA CHOWDARY,
CH MADHUSUDHAN, R PRATAP REDDY

INTRODUCTION :

OSMANIA
MEDICAL
COLLEGE
,
HYDERABAD
Solid
pseudopapillary
neoplasms
(FRANTZ

TUMOUR) of the pancreas are rare neoplasms of low

grade

malignant

potential

described in 1959 by Frantz.

which

were

first

(1)

These account for 1

2% of pancreatic neoplasms

and approximately

(2)

13% of surgically resected cystic lesions of the

pancreas.
METHODS :
We
present
our
experience
with
these
tumors.
Between 2013 and 2015, we encountered 6 cases
(3)

CT ABDOMEN SHOWING HETEROGENOUS

MASS
A- BODY AND TAIL OF PANCREAS
B- HEAD OF PANCREAS

of SPN of the pancreas. Clinico-pathological details,

intervention done and follow up of all the cases
were studied and reported here.

RESULTS :
5 of the 6 cases were female with a mean age of
presentation of 24.17 years with age ranging from 11-

CUT SECTION OF DISTAL PANCREATECTOMY AND

SPLEENECTOMY SPECIMEN SHOWING AREAS OF
SOLID AND CYSTIC COMPONENT IN THE TUMOUR OF
THE PANCREAS

48 years.4 cases presented with abdominal pain as

the major complaint, 2 cases presented with lump in
the abdomen. 3 cases originated from the body of the
pancreas, 2 the tail and 1 in the head of the pancreas.

Distal pancreatectomy was done in 4 cases, 1 case

underwent central pancreatectomy and 1underwent
whipples procedure. Post operatively 1 case, which

A 40X VIEW

B
B 100X

VIEW
PERITHELIOMATOUS ARRANGEMENT OF TUMOUR
CELLS GIVING PSEUDOPAPILLARY APPEARANCE

was associated dorsal pancreatic agenesis developed A

diabetes. On follow up of all the cases, there was no

CONCLUSION :

recurrence of the tumor.

SPNs are rare neoplasms, typically affecting

young women

(4)

without notable symptoms

,with a low malignant potential but excellent

prognosis.

(5)

Diagnosis can be made by pre-

operative imaging and is confirmed by typical

histologic and IHC staining characteristics.

(6)

Radical surgical resection with clear margins is C

the treatment of choice. Role of enucleation
(7)

still is not defined.

A - BETA CATENIN CYTOPLASMIC POSITIVITY

B VIMENTIN CYTOPLASMIC POSITIVITY
C PR RECEPTOR POSITIVITY
D CHROMOGRANIN NEGATIVE

REFERENCES:
1. Frantz VK: Tumors of the pancreas. In: Frantz VK, editor. Atlas of Tumor Pathology. Washington DC: Armed Forces Institute of Pathology. 1959. pp 3233.
2. Martin RC, Klimstra DS, Brennan MF, et al.: Solid-pseudopapillary tumor of the pancreas: A surgical enigma? Ann Surg Oncol 2002;9:3540.
3. Goh BK, Tan YM, Cheow PC, et al.: Cystic lesions of the pancreas: An appraisal of an aggressive resection policy adopted at a single institution during 15
years. Am J Surg 2006;192:148154.
4. Klimstra DS, Wenig BM, Heffess CS: Solid-pseudopapillary tumor of the pancreas: A typically cystic carcinoma of low malignant potential. Sem Diagn Pathol
2000;17:6680.

5. Papavramidis T, Papavramidis S: Solid pseudopapillary tumors of the pancreas: Review of 718 patients reported in the English literature. J Am
Coll Surg 2005;200:965972.