Bowens Disease

Disusun oleh :
Elfinsa Ismi Istiqomah
030 10 092

Pembimbing:
dr. Sri Primawati Indraswari, Sp.KK, MM, MH

Pendahuluan

Djuanda. A, Hamzah. M, Aisah. S. Ilmu Penyakit Kulit dan Kelamin. Edisi 7. Jakarta: Balai Penerbit FKUI. 2015.
Ali Asra. Mc graw hill Speciality Board Review Dermatology- A Pictorial Riview Ed 2nd. Bowen disease. Medical Publishing Division :
Texas. 2010. p 4647, 73, 195196, 196f, 290t.
[1]
[2]

Amerika

Djuanda. A, Hamzah. M, Aisah. S. Ilmu Penyakit Kulit dan Kelamin. Edisi 7. Jakarta: Balai Penerbit FKUI. 2015.
Fauci, Anthony, S. Harrison's Principles of Internal Medicine, 14th Ed. New York: McGraw Hill, Inc.p 1998.
[3] Oemiati Ratih, EkowatiRahajeng, Kristianto Antonius Yudi. Prevalensi tumor dan beberapa faktor yang mempengaruhinya di Indonesia.
Jakarta: Badan Penelitian dan Pengembangan Kesehatan. 2011
[1]
[2]

Di RSUD Kardinah pada tahun 2015 didapatkan insiden kanker

kulit non-melanoma sebanyak 16 kasus. Terdiri dari karsinoma
sel basal 5 kasus, dan karsinoma sel skuamosa 11 kasus.
Prevalensi Kanker kulit non-melanoma berdasarkan Jenis kelamin di RSUD Kardinah tahun 2015

40%

Laki-laki
60%

Prevalensi Kanker kulit non-melanoma berdasarkan Kelompok usia tahun 2015

12

Perempuan

10
8

Jumlah Pasien

6
4
2
0

< 14 th

15 -24 th 25 - 44 th 45 - 64 th > 66 th

Sedangkan, insiden kanker kulit non-melanoma di RSUD

Kardinah pada tahun 2016 hingga bulan april didapatkan
sebanyak 3 kasus kasus. Terdiri dari karsinoma sel basal 3
kasus, dan karsinoma sel skuamosa 0 kasus.
Prevalensi Kanker kulit non melanoma Berdasarkan Jenis Kelamin di RSUD Kardinah Tahun 2016 hingga bulan april

33%
Laki-laki

Prevalensi Kanker kulit non-melanoma berdasarkan Kelompok usia tahun 2016 hingga bulan april

Perempuan
1.2

67%

1
0.8
0.6
Jumlah Pasien

0.4
0.2
0

Anatomi

[1] Perdanakusuma, David. Anatomi Fisiologi Kulit dan Penyembuhan Luka. Surabaya: Surgetor 2008

Sistem saraf
Ada 3 macam serabut saraf yag
terdapat pada kulit, yaitu :
Serabut

[1] Djuanda. A., Hamzah. M., Aisah. S. Ilmu Penyakit Kulit dan Kelamin. Edisi 7. Jakarta: Balai Penerbit FKUI. 2015

Vaskularisasi Kulit
P
Papilla
Arteri
Epidermis
leksusdermis
antara(1
dermis
arteri,dan
1 vena)
subkutis

[1]

Perdanakusuma, David. Anatomi Fisiologi Kulit dan Penyembuhan Luka. Surabaya: Surgetor 2008

Fisiologi Kulit
Fungsiimunologi
Peran
proteksi
ekskresi
absorbsi
pembetukan
presepsi
keratinisasi
termoregulasi
pembentukan
kulitpigmen
vitamin D

[1] Djuanda. A., Hamzah. M., Aisah. S. Ilmu Penyakit Kulit dan Kelamin. Edisi 7. Jakarta: Balai Penerbit FKUI. 2015

Bowens disease
Definisi

[1]
[1]

Bowen JT. A study of Two cases of Chronic Atypical Epithelial proliferation. J Cut Dis 1912; 30: 241-55
Mark P Eid. Bowen Disease. 2009. Available from: http://emedicine.medscape.com/article/1100113-overview

Lapisan kulit pada Karsinoma Sel Skuamosa

(Kanker Kulit Non Melanoma) 11

Cox N. H., D. J. Eedy, C. A. Morton. British Journal of Dermatologists. Guidelines for management of Bowen's disease. UK: British Association of
Dermatologists. 2006. p11-5
[1]

Cox N. H., D. J. Eedy, C. A. Morton. British Journal of Dermatologists. Guidelines for management of Bowen's disease. UK: British Association of
Dermatologists. 2006. p11-5
[2]
Djuanda. A., Hamzah. M., Aisah. S. Ilmu Penyakit Kulit dan Kelamin. Edisi 7. Jakarta: Balai Penerbit FKUI. 2015
[1]

Etiologi

Radiasi seperti sinar ultraviolet, photochemotherapy, radiotherapy

Jamez WD, Berger TG, Elston D. Andrews Diseases of The Skin: Clinical Dermatology. Tenth Edition. Canada: Saunders Elsevier. 2006. p 652-56
Mihalis EL, Wysong A, Boscardin WJ, et al Factors affecting sunscreen use and sun avoidance in a U.S. national sample of organ transplant recipients. Br J
Dermatol. 2013 Feb;168(2):346-53
[1]
[2]

Histopatologik

Sel tampak membesar diluar batas, inti berwarna

keungu-unguan dan anak inti kecil yang mutipel serta
mencolok. Membentuk kumpulan yang mengelilingi
keratinosit non neoplastik
[1] Jamez WD, Berger TG, Elston D. Andrews Diseases of The Skin: Clinical Dermatology. Tenth Edition. Canada: Saunders Elsevier. 2006

Gambaran
Klinis Bowens
disease
Serang bagian
Kulit

[1]
[2]

Wolff K, Johnson RA, Suurmond D. Fitzpatricks Color Atlas and Synopsis of Clinical Dermatology. Fifth Ed. New York: McGraw-Hill
Martis John J. S, MARTIS J ,et al. Bowens Disease on the Anterior Abdominal Wall. Journal of Clinical and Diagnostic Research. 2009

Karsinoma Sel
Skuamosa
Intraepidermal pada
kuku

Makula erimatosa,
skuamosa

Tumor soliter
dengan hasil biopsi
menunjukkan
Bowens disease

rtis John J. S, MARTIS J ,et al. Bowens Disease on the Anterior Abdominal Wall. Journal of Clinical and Diagnostic Research. 2009
H., D. J. Eedy, C. A. Morton. British Journal of Dermatologists. Guidelines for management of Bowen's disease. UK: British Association of Dermatologists

Erythroplasia of
Queyrat, squamous cell
carcinoma in situ of the
glans penis 2
Karsinom
a sel
skuamos
a in situ

[1]

Ali Asra. Mc graw hill Speciality Board Review Dermatology- A Pictorial Riview Ed 2nd. Bowen disease. Medical Publishing Division : Texas. 2010

Pemeriksaan Penunjang
Pemeriksaan

[1] Djuanda. A., Hamzah. M., Aisah. S. Ilmu Penyakit Kulit dan Kelamin. Edisi 7. Jakarta: Balai Penerbit FKUI. 2015

[1]

Djuanda. A., Hamzah. M., Aisah. S. Ilmu Penyakit Kulit dan Kelamin. Edisi 7. Jakarta: Balai Penerbit FKUI. 2015

Penatalaksanaan
Kemoterapi Topical

Cox N. H., D. J. Eedy, C. A. Morton. British Journal of Dermatologists. Guidelines for management of Bowen's disease. UK: British Association of Dermatologists.
2006
[2]
Ahmed, I., J., S. Berth-Jones, Charles Holmes, C. J. O. Callaghan, and A. Ilcyhyshyn. Comparison of cryotherapy with curettage in the treatment of Bowen's disease: a
[1]

Pencegahan
Hindari p

[1]

Naylor, Mark. The Epidemic of Nonmelanoma Skin Cancer: Prevention, Diagnosis, and Treatment. 2004. Available: http://cme.medscape.com/viewarticle/478435

Prognosis

dubiadiobati
tidak
Metastasis
Tanda
ad
daerah
adanya
bonam
kelenjar
dapat
vulva
kanker
menjadi
getah
adanya
kulit bening
non
karsinoma
kegansan
melanoma
uterus
sel dan
skuamosa
, serviks
keganasan
invasif
dan internal
vagina. (etiolog

Bowens disease

[1] MacKie Rona M. Skin Cancer. United Kingdom: Martin Dunitz. 1989. p 87-93

Bowens disease

III. RINGKASAN

Ali Asra. Mc graw hill Speciality Board Review Dermatology- A Pictorial Riview Ed 2nd. Bowen disease. Medical Publishing Division : Texas. 2010. p 4647, 73, 195196,
196f, 290t.
[1]
Djuanda. A, Hamzah. M, Aisah. S. Ilmu Penyakit Kulit dan Kelamin. Edisi 7. Jakarta: Balai Penerbit FKUI. 2015.
[1]
Jamez WD, Berger TG, Elston D. Andrews Diseases of The Skin: Clinical Dermatology. Tenth Edition. Canada: Saunders Elsevier. 2006. p 652-56
[1]

DAFTAR PUSTAKA
1.
2.

3.
4.
5.
6.

7.
8.
9.
10.
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12.

Djuanda. A., Hamzah. M., Aisah. S. Ilmu Penyakit Kulit dan Kelamin. Edisi 7. Jakarta:
Balai Penerbit FKUI. 2015.
Ali Asra. Mc graw hill Speciality Board Review Dermatology- A Pictorial Riview Ed
2nd. Bowen disease. Medical Publishing Division : Texas. 2010. p 4647, 73, 195
196, 196f, 290t.
Fauci, Anthony, S.Harrison's Principles of Internal Medicine, 14th Ed.New York:
McGraw Hill, Inc.p 1998: 303, 548, 1099T.
Lim Pei-wen, Sharen. Skin Cancer. US: Ensiklo. 2008.
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Rumah Sakit Cipto Mangunkusumo,.1985.
Oemiati Ratih, EkowatiRahajeng, Kristianto Antonius Yudi. Prevalensi tumor dan
beberapa faktor yang mempengaruhinya di Indonesia. Jakarta: Badan Penelitian
dan Pengembangan Kesehatan. 2011.
Perdanakusuma, David. Anatomi Fisiologi Kulit dan Penyembuhan Luka. Surabaya:
Surgetor 2008.
Price, Wilson. Patofisiologi, Konsep Klinis Proses-proses Penyakit. Jakarta: EGC.
1995.
Bowen JT. A study of Two cases of Chronic Atypical Epithelial proliferation. J Cut Dis
1912; 30: 241-55
Mark
P
Eid.
Bowen
Disease.
2009.
Available
from:
http://emedicine.medscape.com/article/1100113-overview
Cox N. H., D. J. Eedy, C. A. Morton. British Journal of Dermatologists. Guidelines for
management of Bowen's disease. UK: British Association of Dermatologists. 2006.
p11-5
Jamez WD, Berger TG, Elston D. Andrews Diseases of The Skin: Clinical
Dermatology. Tenth Edition. Canada: Saunders Elsevier. 2006. p 652-56

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Quereux G, NGuyen JM, Dreno B. Human papillomavirus and extragenital in situ
carcinoma. Dermatology. 2004. p 209:405.
Mitsuishi T, Kawana S, Kato T, Kawashima M. Human papillomavirus infection in actinic
keratosis and Bowens disease: comparative study with expression of cell-cycle regulatory
proteins p2, p53, PCNA, Ki-67, and Bcl-2 in positive and negative lesions.Hum Pathol.
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Martis John J. S, MARTIS J ,et al. Bowens Disease on the Anterior Abdominal Wall. Journal of
Clinical and Diagnostic Research. 2009. p1431-33
Ahmed, I., J., S. Berth-Jones, Charles Holmes, C. J. O. Callaghan, and A. Ilcyhyshyn.
Comparison of cryotherapy with curettage in the treatment of Bowen's disease: a
prospective study. UK: British Journal of Dermatology. 2000. p143:759-766.
Morton, Colin, A., Colin Whitehurst, John H. McColl, James V. Moore, and Rona M. MacKie.
Photodynamic Therapy for Large or Multiple Patches of Bowen Disease and Basal Cell
Carcinoma. Archives Dermatology. 2001. p137:319-324.
Morton CA, Whitehurst C, McColl JH, et al. Photodynamic therapy for large or multiple
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Naylor, Mark. The Epidemic of Nonmelanoma Skin Cancer: Prevention, Diagnosis, and
Treatment. 2004. Available: http://cme.medscape.com/viewarticle/478435