Kuby IMMUNOLOGY
Sixth Edition
Chapter 8
The Major Histocompatibility
Complex and Antigen Presentation
Copyright 2007 by W. H. Freeman and Company
- Antigen processing
- Antigen presentation
Inheritance of MHC
Inheritance of MHC
Inheritance of MHC
Inheritance of MHC
Inheritance of MHC
Inheritance of MHC
MHC molecules
Class I MHC
Alpha chain
Transmembrane
Encoded by A, B,
and C regions in
human MHC
complex
Beta 2-
microglobulin
Encoded by highly
conserved gene on
different
chromosome
Class II Molecule
1 and 2 chain
Transmembrane
1 and 2 chain
transmembrane
Figurebshowstop
Viewofpeptidecleft
of alleles
- In humans, ~370 A alleles, 660 B alleles, 190 C
alleles
Location of genes
Human
Class I MHC are red
Telomeric end of HLA
complex
Class II MHC are blue
Centromeric end of
HLA complex
Cellular Expression of
MHC
MHC Restriction
MHC Restriction
Mice immunized
with lymphocytic
choriomenigitis virus
(LCM)
Animals spleen
cells were extracted
(containing Tc cells)
Antigen Presenting
Pathways
Cystolic Pathway
infected cell
Antigens presented on MHC Class I to Tc cells
Endocytic Pathway
Exogeneous antigen taken in by
Cystolic Pathway
Endogenous
Figure below:
be degraded
Endocytic Pathway
Exogenous