Available at blog:
http://industry.bnet.com/pharma/10001228/e-mail-astrazeneca-knew-in1997-that-seroquel-caused-weight-gain/
Seroquel documents
These slides are excerpts from the
files, and illustrate issues suggestive
of buried trials, data manipulation and
possible obscuring of adverse drug
event information.
Thus they are selective excerpts.
To read in full context go to the
relevant file according to the code
number.
pharmacologist Dr Plunkett
the sales messages contradicted what AstraZeneca knew to be true
about...weight gain
pharmacologist Dr Plunkett
AZ aware of Seroquel association with diabetes/hyperglycemia
1999
pharmacologist Dr Plunkett
Seroquel package insert distorts risk of diabetes/hyperglycemia
pharmacologist Dr Plunkett
Discredited AZ sponsored study claimed Seroquel cured diabetes
pharmacologist Dr Plunkett
FDA admonish AZ in 2006 but in Oct 2007 label still inadequate
pharmacologist Dr Plunkett
Diabetes level blood sugar changes downplayed as
hyperglycemia
04_exhibit_27
04_exhibit_27
2nd email 6 Dec 99 - can we present the EPS data in isolation given nature of
other results
data
5th email 6 Dec 99 thus far we have buried Trials 15, 31, 56 and now
considering COSTAR
how do we face the world when they begin to criticize us for suppressing
data
Omnibus MSJExhibit 2
AZ marketing
director
deposition Apr 2008
AZ
marketing
director
deposition
Apr 2008
AZ marketing director
deposition Apr 2008
Dr Arnott
Dr Arnott
43_exhibit_12
43_exhibit_15
43_exhibit_15
promotional material
promotional material