PREGNAN
CY
Bethel Mulugeta
Year III Medical Student of
AAU
August 26, 2016
Outline
Introduction
Definition
Incidence
Epidemiology
Classification
Risk factors
Natural course
Diagnosis
History
Physical examination
Lab investigation
Imaging studies
Principles of
management
Ectopic Pregnancy
Introduction
Ectopic pregnancy is the implantation of
blastocyst outside the endometrial
cavity or uterine proper
It causes:
major maternal morbidity & mortality
adversely affects future reproductive function &
economic burden of health care for women
Ectopic Pregnancy
Contd
Incidence
1-2% of pregnancies
Through time the incidence is increasing;
PID
Contraceptives use
Early Diagnosis
ART
Tubal surgery
Ectopic Pregnancy
Contd
Epidemiology
Accounts for 2% of all 1st trimester pregnancies
Leading cause of maternal mortality during 1st
trimester (10-14%)
Around 9% of all pregnancy related deaths
Ectopic Pregnancy
Classification
Based on the involvement of the tubes:
Tubal (95%)
Ampullary (70%)
Isthmic (12%)
Fimbria (11%)
Interstitial (2.4%)
Nontubal (5%)..20% of
-
Ectopic Pregnancy
Ectopic Pregnancy
Risk Factors
Congenital
Tubal hypoplasia
Partial stenosis of the tubes
In utero DES exposure
Congenital diverticulitis
Acquired
Inflammatory PID [6x], STI, purperal sepsis, post abortal infection
Surgical Constructive (tubal) surgery [4-5x], infertility surgery,
Apendicitis surgery, tubal sterilization
Tumor Ovarian, myoma
Miscellaneous Endometriosis, previous ectopic pregnancy [7x],
decreased ciliary motility, smoking, IUCD [6-10x], previous CS,
Other Increasing age, blacks, low socioeconomic status, infertile
Ectopic Pregnancy
Contd
Risk of recurrence rate:
With 1 EP = 15%
With 2 EP = 25%
Generally, 7x higher
i.e. Patient counseling and screening is
important!
Ectopic Pregnancy
Natural course
Tubal rupture
Rupture in the first week . Isthmic EP
Associated hypovolemia
Tubal abortion
Ampullary EP
Involution/resorption of conceptus
Re-implant
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Diagnosis
History
Physical examination
Lab investigation
Imaging studies
Ectopic Pregnancy
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Contd
History
Variable presentation:
Ectopic Pregnancy
12
Contd
Physical Examination
Vital sign
Abdomen
Acute abdomen - direct or rebound tenderness
Sign of fluid accumulation
Pelvic
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Investigation
Clinical diagnosis based on the results of:
the imaging studies (ultrasound) and
laboratory tests (hCG)
Other basic diagnostic tools: CBC, BG/Rh,
urinalysis, pregnancy test
Ectopic Pregnancy
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Discriminatory zone:
Contd
15
Contd
A negative ultrasound examination at
hCG levels below the discriminatory zone
is consistent with:
an early viable intrauterine pregnancy
or
an ectopic pregnancy or
Non viable intrauterine pregnancy.
Such cases are termed "pregnancy of
Ectopic Pregnancy
unknown location"
and 8 to 40 percent16
Contd
Other diagnostic tests:
Serum progesterone level --- below 5-10ngm/mL
Doppler US ---- Ring of Fire (cyst surrounded by BV)
Curettage
Laparoscopy --- Gold Standard
Culdocentesis
MRI
i.e. Do not provide additional clinically useful information.
Ectopic Pregnancy
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Principles of Management
Depends on:
Level of hCG
Size of the mass
Site of the ectopic pregnancy
General condition of the patient (Hemodynamic stability)
Available recourses
Ectopic Pregnancy
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Contd
Surgical
Indicated especially at hemodynamic
instability and emergency cases
Laparatomy QUICKELY!!
Salphingectomy
Salphingostomy
Salphingotomy
Ectopic Pregnancy
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Contd
Medical therapy (MTX)
Contraindications
Candidates:
hemodynamically stable,
willing and able to
comply with post
treatment follow-up,
B hCG 5000 mIU/mL,
no fetal cardiac activity
size < 3.5cm
Hemodynamically unstable
hepatic/renal dysfunction
Immunodeficiency,
Breast feeding
peptic ulcer disease
Hypersensitivity to MTX
Coexistent viable intrauterine pregnancy
unable to be compliant with posttherapeutic monitoring
Do not have timely access to a medical
institution
Ectopic Pregnancy
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Contd
Expectant
Indicated only at;
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Reference Material
Williams Obestetrics 23rd edition
Current Diagnosis & Treatment Obstetrics &
Gynecology, Tenth Edition
Berek & Novak's Gynecology, 14th Edition
Ectopic Pregnancy
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Thank You!!!
Ectopic Pregnancy
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