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Penggunaan LAMA pada

PPOK

Subtype muscarinic
M1 receptors ('neural') producing slow excitation
of ganglia.
M2 receptors ('cardiac') causing decrease in
cardiac rate and force of contraction (mainly of
atria).
M3 receptors ('glandular') causing secretion,
contraction of visceral smooth muscle, vascular
relaxation.

Subtype muscarinic
M3
Receptor
is
the
primary
subtype
responsible for bronchial and tracheal
smooth muscle contraction; this is evident
from the functional affinities of a variety of
subtype selective antagonists in airway
tissues from diverse species, including
humans

Muscarinic antagonists
Muscarinic antagonists Most important
compounds
are
atropine,
hyoscine,
ipratropium and pirenzepine.
Main effects are inhibition of secretions;
relaxation of smooth muscle (gut,
bronchi, biliary tract, bladder); inhibition
of gastric acid secretion (especially
pirenzepine);

2 adrenoceptors
Their primary effect in asthma is to dilate the
bronchi by a direct action on the 2
adrenoceptors of smooth muscle. Being
physiological
antagonists
of
bronchoconstrictors, they relax bronchial
muscle whatever the spasmogens involved.
They also inhibit mediator release from mast
cells and TNF- release from monocytes, and
increase mucus clearance by an action on
cilia.