Nose
Pharynx (throat)
Middle ear
Eustachian tubes
Figure 24.1
Larynx
Trachea
Bronchial tubes
Alveoli
Pleura
Figure 24.2
Pharyngitis
Laryngitis
Tonsillitis
Sinusitis
Epiglottitis: H. influenzae type b
Streptococcal Pharyngitis
Also called strep throat
Streptococcus
pyogenes
Resistant to
phagocytosis
Streptokinases lyse
clots
Streptolysins are
cytotoxic
Diagnosis by enzyme
immunoassay (EIA)
tests
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Figure 24.3
Scarlet Fever
Streptococcus pyogenes
Pharyngitis
Erythrogenic toxin produced by lysogenized
S. pyogenes
DIPHTHERIA INFECTION
Diphtheria
Corynebacterium diphtheriae: Gram-positive rod
Diphtheria toxin produced by lysogenized C.
diphtheriae
Figure 24.4
Diphtheria
Diphtheria membrane: Fibrin, tissue, bacterial
cells
Figure 24.5
OTITIS MEDIA
Otitis Media
Etiologic Bacteria
S. pneumoniae (35%)
H. influenzae (2030%)
M. catarrhalis (1015%)
S. pyogenes (810%)
S. aureus (12%)
Incidence of S.
pneumoniae reduced
by vaccine
Figure 24.6
Microbiology examination :
Gram stain as guidance from the swab or parentecis
of the fluid.
Followed by appropriate Culture of the suspected
bacteria.
Capsule
Tracheal cytotoxin of
cell wall damaged
ciliated cells
Pertussis toxin
Prevented by DTaP
vaccine (acellular
Pertussis cell
fragments)
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Figure 24.7
TUBERCULOSIS
Tuberculosis
Mycobacterium tuberculosis
Acid-fast rod; transmitted from human to human
Figure 24.8
Tuberculosis
M. bovis: <1% U.S. cases; not transmitted from
human to human
M. avium-intracellulare complex infects people with
late-stage HIV infection
Tuberculosis
Figure 24.11a
Figure 24.11b
Figure 24.10
Diagnosis of Tuberculosis
Tuberculin skin test screening
Positive reaction means current or previous
infection
Followed by X-ray or CT exam, acid-fast staining
of sputum, culturing of bacteria
PNEUMONIA
Pneumococcal Pneumonia
Streptococcus pneumoniae
Gram-positive encapsulated diplococci
Figure 24.12
Pneumococcal Pneumonia
Symptoms: Infected alveoli of lung fill with
fluids; interferes with oxygen uptake
Diagnosis: Optochin-inhibition test or bile
solubility test; serological typing of bacteria
Prevention: Pneumococcal vaccine
Mycoplasmal Pneumonia
Primary atypical
pneumonia; walking
pneumonia
Mycoplasma
pneumoniae
Pleomorphic,
wall-less bacteria
Common in children
and young adults
Figure 24.13
Mycoplasma pneumoniae
Figure 11.20
Mycoplasmal Pneumonia
Symptoms: Mild but persistent respiratory
symptoms; low fever, cough, headache
Diagnosis: PCR and serological testing
Treatment: Tetracyclines
Legionellosis
Sputum :
Gram stain and Culture
on Specific Agar
Legionella pneumophila
Gram-negative rod
Found in water
Transmitted by inhaling
aerosols ec. AC and not
transmitted from human
to human
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Psittacosis (Ornithosis)
Sputum :
Gram stain and culture on appropriate media
( hard to grow ) and Serology
Chlamydophila psittaci
Gram-negative intracellular bacterium
Psittacosis (Ornithosis)
Figure 11.24a
Chlamydial Pneumonia
Sputum :
Gram stain and Serology
Chlamydophila pneumoniae
Transmitted from human to human
Figure 11.24b
Figure 24.14
Q Fever
Symptoms: Mild respiratory disease lasting 12
weeks; occasional complications such as
endocarditis occur
Diagnosis: Growth in cell culture
Treatment: Doxycycline and chloroquine
Melioidosis
Causative agent: by Burkholderia pseudomallei
Reservoir: Soil
Mainly in southeast Asia and northern Australia
Symptoms: Pneumonia, or tissue abscesses and
severe sepsis
Diagnosis: Bacterial culture
Treatment: Ceftazidime
Diseases in Focus:
Common Bacterial Pneumonias
Viral Pneumonia
Viral pneumonia occurs as a complication of
influenza, measles, or chickenpox
Viral etiology suspected if no other cause is
determined
Figure 24.15
Antigenic drift
Point mutations in genes encoding HA or NA spikes
May involve only 1 amino acid
Allows virus to avoid mucosal IgA antibodies
Influenza Serotypes
Type
Antigenic
Subtype
Year
Severity
H3N2
H1N1
H2N2
H3N2
H1N1
1889
1918
1957
1968
1977
Moderate
Severe
Severe
Moderate
Low
None
1940
Moderate
None
1947
Very mild
Pneumocystis Pneumonia
Aspergillus fumigatus
Mucor
Rhizopus
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