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MICROPHENIS

Micropenis : stretched penile length of less


than 2.5 standard deviations (SDs) below the
mean for age.
The penis grows very little until puberty
when testosterone levels begin to rise.

PATHOPHYSIOLOGI

Fetal production of testosterone and its


peripheral conversion to dihydrotestosterone
(DHT) is necessary for normal male
development.
After birth, gonadotropin (luteinizing
hormone [LH] and follicle stimulating
hormone [FSH]) and testosterone production
decrease.

Beginning at about age 1 week, gonadotropin


and testosterone levels begin to rise again to
pubertal levels, peaking at age 1-3 months
Decreasing to prepubertal levels by age 6
months.

Genetic syndromes in which micropenis may


be a feature include Prader-Willi, Klinefelter,
and Noonan syndromes

TREATMENT

Testosterone therapy in the form of 3-6


monthly intramuscular (IM) injections
Testosterone therapy has generally been
found effective in treating micropenis due to
testosterone deficiency.