Ranitidin

RUMUS MOLEKUL
RANITIDINE
C13H22N4O3S
NN-Dimethyl-5-[2-(1methylamino-2nitrovinylamino)ethylthiomethyl]furfurylamine
Memiliki struktur imidazole,
dapat terdistribusi luas ke
seluruh tubuh, termasuk air
susu dan dapat melewati
plasenta.

Indikasi
Gastric Ulcer
- Pengobatan jangka pendek active benign gastric ulcer
- Pemeliharaan penyembuhan dan penurunan kekambuhan
ulkus lambung
Duodenal Ulcer
- Pengobatan jangka pendek ulkus duodenum aktif
- Pemeliharaan penyembuhan dan penurunan kekambuhan ulkus
duodenum
Pathologic GI Hypersecretory Conditions
pengobatan jangka panjang dari sindrom Zollinger-Ellison,
mastositosis sistemik, hipersekresi pasca operasi, "short-gut"
sindrom
Gastroesophageal Reflux (GERD)
- Achieve acid suppression, control symptoms, and prevent
complications.
Pustaka: AHFS 2011, A to Z Drug Facts, DIH 17th Ed.,
- Menjaga penyembuhan dan mengurangi kambuhnya esofagitis
erosif

Komposisi Ranitidine HCl

Routes

Dosage
Forms

Strengths

Brand Names

Manufact
urer

Oral

Capsules,
liquidfilled

150 mg (of
ranitidine)*

Ranitidine
Hydrochloride
Capsules

Sandoz,
Teva

300 mg (of
ranitidine)*

Ranitidine
Hydrochloride
Capsules

Sandoz,
Teva

Solution

75 mg (of ranitidine)
per 5 mL

Zantac Syrup
(with alcohol 7.5%
and parabens)

GlaxoSmith
Kline

Tablets,
filmcoated

75 mg (of
ranitidine)*

Ranitidine
Hydrochloride
Tablets

Ranbaxy,
Sandoz,
Teva,
Watson

Zantac 75

Pfizer

150 mg (of
ranitidine)*

Zantac

GlaxoSmith
Kline

Zantac Maximum
Strength 150

GlaxoSmith
Kline

300 mg (of
ranitidine)*

Zantac

GlaxoSmith
Kline

Sumber: AHFS Drugs Information Essentials, November 2011

Cont...
Komposisi Ranitidine HCl
Route
s
Oral

Dosage
Strengths
Forms

Brand Names

Manufac
turer

Tablets,
for
solution

25 mg (of
ranitidine)

Zantac
EFFERdose
GlaxoSmi
(with aspartame thKline
and povidone)

150 mg (of
ranitidine)

Zantac
EFFERdose
GlaxoSmi
(with aspartame thKline
and povidone)

Parent
eral

25 mg (of
Injection ranitidine) per
mL*

Ranitidine
Injection (with
phenol 0.5%)

Bedford

Zantac (with
phenol 0.5%)

GlaxoSmi
thKline

Injection
, for
preparat
ion of IV
admixtu

25 mg (of
ranitidine) per mL Zantac (with
GlaxoSmi
(1 g) pharmacy
phenol 0.5%)
thKline
Sumber: AHFS Drugs Information Essentials, November 2011
bulk package

Komposisi Ranitidine
HCl dalam NaCl
Rout
es

Dosa
ge
Strengths
Form
s

Brand
Names

Manufact
urer

Zantac
1 mg (of
Premixed (in
ranitidine) per
Parent Injecti
flexible plastic GlaxoSmit
mL (50 mg) in
eral
on
container;
hKline
0.45% Sodium
preservativeChloride
Sumber: AHFS Drugs Information Essentials, November 2011
free)

Kandungan Ranitidine
Capsule 150 mg, 300 mg
Infusion [premixed in NaCl 0.45%;
preservative free]:
Zantac : 50 mg (50 mL)
Injection, solution: 25 mg/mL (2 mL, 6
mL)
Zantac : 25 mg/mL (2 mL, 6 mL,
40 mL) [contains phenol 0.5% as
preservative]
Syrup: 15 mg/mL (5 mL, 10 mL, 473
mL)
Zantac : 15 mg/mL (473 mL)
[contains alcohol 7.5%;
peppermint flavor]

Tablet : 75 mg [OTC], 150 mg,

300 mg
Zantac : 150 mg, 300 mg
Zantac 75 : 75 mg
Zantac 150 : 150 mg
Tablet, for solution, oral
[effervescent]:
Zantac EFFERdose: 25 mg
[contains
phenylalanine
2.81 mg/tablet,
sodium 1.33
mEq/tablet,
sodium benzoate]

Sumber: Drugs Information Handbook 17th edition, p.6109-6110