ASMA 2015

GINA
Iniciativa Global para el Asma
(Global Initiative for Asthma)
Un proyecto colaborativo del National
Heart, Lung, and Blood Institute
(Estados Unidos), y al que se unen
decenas de organizaciones de todo el
mundo.
Es el proyecto internacional ms

Definicin

El asma es una enfermedad crnica

inflamatoria
inferiores,

de

las

vas

caracterizada

respuesta

aumentada

areas
por

la

diversos

estmulos, que se manifiesta por tos,

disnea,

opresin

sibilancias,

que

torxica
pueden

y/o

revertir

THE CHANGING FACES OF ASTHMA

Time PeriodGoal of Management
1960s
1970s
1980s
1990s
2000s
2010s

Relieve
bronchospasm
Prevent
bronchospasm
Preventallergen
induced
bronchospasm
Preventandresolve
inflammation

Medication
s
Epinephrine
Albuterol,theophylline
Cromolyn
Inhaledglucocorticoids
Leukotrienemodifiers
Longactingagonists
Combinationtherapy
AntiIgE
Biomarkers/Genetics;

THE CHANGING FACES OF ASTHMA

Time PeriodGoal of Management
1960s
1970s
1980s
1990s
2000s
2010s

Relieve
bronchospasm
Prevent
bronchospasm
Preventallergen
induced
bronchospasm
Preventandresolve
inflammation

Medication
s
Epinephrine
Albuterol,theophylline
Cromolyn
Inhaledglucocorticoids
Leukotrienemodifiers
Longactingagonists
Combinationtherapy
AntiIgE
Biomarkers/Genetics;

Improving Asthma
Control
Goals of long-term control
therapy
Prevent symptoms
Improve pulmonary function
Reduce inflammation
Resolve and prevent
progression

EarlyInterventionforAsthmaPrevention
Environment
Allergens
Microbes
Pollutants
Stress

Biological &
Genetic Risk

Age Immune
Lung
Repair

1o
Prevention

Aberrant immune development & responses

Atopy

Airways
Injury
Aberrant
Repair

Viral infections
Aeroallergens
Pollutants/toxicants

2o
Prevention

Persistent inflammation
BHR
Tissue remodeling
Lung growth/differentiation

Early
Intervention

ASTHMA

- Liu AH. JACI, 113:S19024, 2004.