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Fibromyalgia and

Depression
Rangga Lunesia

Background
The primary and debilitating

Pathophysiology of Fibromyalgia and


Depression: Predisposing,
Precipitating,
and Perpetuating Factors

Raphael et al (2004)

The acute stress response

Reactive,Melancholic, and
Atypical Depression
Depression may also take the form

Maturation of FM and Depression : From Hypercortisolism and Melancholic


Depression
to
Hypocortisolism
and
Atypical
Depression

The presence of melancholic and atypical depression in

Scenarios of Linked FM and


Depression
A physiological progression in FM and a transition from a

Laboratory Evidence for the Role


of Depression in FM
Ang et al (2011)

Treatment Evidence from


Clinical Trials
Depression and FM also appear to be linked because drugs

Summary
FM has been included in the family of affective spectrum

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