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Dr. dr. Amarullah H.

Siregar, FAAFM, FAARM, FAABM, DIHom, DNMed, MSc, MA, ND, PhD

Konsultan
Naturopati, Anti Aging, Wellness & Functional Med

KOMISI NASIONAL SAINTIFIKASI JAMU


POKJANAS TRADISIONAL ALTERNATIF KOMPLEMEN
ACADEMIC RECORD
Medical Doctor
MSc, Health Care
D.I.Hom
D.Nat.Med
MA, Wellness
PhD, Health Science
Doctor, Naturopathy
Fellow
Fellow
Fellow
Fellow
Post Doctoral

North Sumatra University Medan


University of Wales Swansea, UK
British Institute of Homeopathy London, UK
Galien University London, UK
Clayton College of Natural Health Alabama, USA
Fairfax University New Orleans, USA
Clayton College of Natural Health Alabama, USA
British Institute of Homeopathy London, UK
American Advance Restorative Medicine
American Academy of Functional Medicine
American Botanical Council
Clayton College of Natural Health Alabama, USA

he Role of Phytomedicin
for
Anti Aging Intervention
Amarullah H. Siregar

Seminar PDHMI Sumatera Selatan


Palembang, 23 Februari 2013

GLOBAL TRADE
17 February 2010

Health food supplements market in Indonesia

US$ 303 million


- 80% import
- US products US$ 160 million (60%)
The prospect of sales
- 20 25% increase over the next 2 years
- upward trend of preventive measures
EXCELLENT FOR US HEALTH MANUFACTURES
TREND IN INDONESIA USING NON PRESCRIPTIO

Chronological age

The yearly age, relates to the


number of years that we have lived
since we were born

Biological age
The performance of an individuals
body
system from mental
function to sexual performance to
physical strength
Relationship between chronological
age and programmed cell death
(apoptosis) which seems to be an
essential part of the life of

Air Pollution
Processed
AirFoods
Pollution

Food additives/
Chemicals
Pesticide/
Herbicide

External Toxins

Stress

Tobacco
smoke

Excess food
intake

Drinking
water

XENO-BIOTIC

DEGENERATIVE PROCESS
Hormonal
Skin
Immune

Psychological
Obesity
Organ damage

PREMATURE AGING

Body Pollution, 2003

MEDICINE TODAY
CONVENTIONAL

NON CONVENTI

Naturopath
Anti Aging M
Wellness M
Functional M
Restorative

Long life; the great duration


of individual life

Ultimate achievements of
biological age and practical
immortality , which we live
vital life spans
Find solutions to eliminate or
at least to alleviate the

Definition of what is old is changing daily


New treatment added years of life

ANTI AGING MEDICINE


Anti Aging Medicine not to extend life
but
to delay the onset of aging process
for
achieving fit and vital age

Population in millions

120
55-64
90-

65-74
75-84
85+

60-

30-

1900

1930

1960

1990

2020

2050

naturoceutical

Anti aging interventions


HORMONE
STRESS
EXERCISE
NATUROCEUTICALS

Signal transduction

Receptors

Y
Transporter

Ion
channels

YY

Electron transport
DNA
- Replication
- Transcription
- DNA repair

Protein
biosynthesis

Mitochondrion

n
u
c
l
e
u
s

Enzymes

RNA

lysosome

Cell membrane
Cytoskeleton
(actin, microtubules)

Posttranslational
protein modification

Natural Biomolecular Engin

Nature Chemical Biology. Volume: 6, 868870

HERBAL DELIVERY SYSTEM


Novel drug delivery systems (NDDS)

Fitoterapia.. Volume 81, Issue 7, October 2010, Pages

Advanced Drug Delivery Reviews. Available online 20 July 2012

AGING PATHWAY

BIOMOLECULAR
AGING

Mechanisms of Ageing and Development


Volume 129, Issue 5, May 2008, Pages 243253

IGF secretion

Biological clock

Science 16 April 2010:


Vol. 328 no. 5976 : 321-326

PHYTOMEDICINE AGING

Phytomedicine. Volume 19, Issue 1, 15 December 2011, Pages 6473

Phytomedi
cine

Biochemical and Biophysical Research Communications


Volume 378, Issue 1, 2 January 2009, Pages 69

LONGEVITY GENE & PHYTOMEDICINE


PTMs

Interacting proteins

Parathymosine

Activator NAD

SIRT1 expression

Nicotinamide adenine dinucleotide

Sirtuin homolog 1

PGC1

Peroxisome coactivator1
Gluconeogenesis
Fatty acid oxidation

FOXO1

SIRT1

Forkhead box 01
Gluconeogenesis
Insulin secretion
Adiponectin production

Nuclear factor kappa B

Insulin secretion
Insulin sensitivity

CRTC2

Creb Regulated
Transcription Coactivator2

GluconeogenesisB

STAT3

LXRs

Liver X receptor
Lipid metabolism

NfkB

AceCS1

Signal Tranducer Activator


Of Transcription3

Gluconeogenesis
Acetyl CoA synthetase
Acetyl CoA scavenger

Pharmacological Research. Volume 62, Issue 1, July

Calorie
restriction

Natural
substances

ology and Medicine.. Volume 51, Issue 2, 15 July 2011, Pages 250256

Phytomedi
cine

Supply of methyl groups


inhibit DNA methylation processes
Modify the use of methyl
groups
DNA methyltransferase
Response
to bioactive
reaction
components
influence DNA
Ability
to interact at molecular
demethylation
level

DNA methylation patterns


Methylatio
n on or off which alters genetic
Switching genes
messages and modify genetic expression

DNA
repair
Carcinogen
metabolism

Hormonal
regulation
Bioactive
component

Cell
cycle

Differentiate

Apoptosis

tss
en
nt
enve ts
n
ro
lap eve
oum
t cll lar
an ce lu
pl fy cel
ive dfi y
ct oodi
m
oa
Bi n nm
caca
Metabolites
Proteins
mRNA
Genes

Metabolic pathways

Functional modules

od Cel
ify lul
re ar e
pl
an spon ven
tc
t
s
om e t o s c a
po
Bi n
n e oa
nt ct
i ve
s

Phenotype

Epigenomic

CH3-DNA

Nutrigenetic

Nutrigenomic

Post translational

DNA

mRNA

Proteins

Bioactive
Food
Components

Enzyme, Structural
Transport, Signaling
caused by
Phosphorylation and
Glycocylation

PHYTOGENOMIC APPROACHES

GENOMIC

METABOLOMIC

PROTEONOMIC

BIO-INFORMATIC
Biomolecular
Bioactive plant component
BIO-ACTIVATION
DNA repair

Cell communication

Cell signaling

GENETIC STABILITY
BIOLOGICAL PROCESS
Van Ommen et al 2002. Curr Opin Biotech; 13 : 517-521

Natural substances
Nutrients
Phytochemicals
Source of
energy

Growth and
Tissues
maintenance

Regulation
Body Process

Life sustaining functions


Metabolisms
Growth &
Development

Body
Organ &
Composition System function

European Nutrigenomic Organization

Plant secondary metabolite


Phytoactive

Phytonutrient
Phytochemical
Phytoenzyme
Phytohormone

Phyto-allel
Human cells & genes

Gene
Gene
Gene
Gene
Gene

transcription
modulation
regulation
translation
expression

Recuperation
Rejuvenation
Revitalization
Miller G, 1997 J of Am Col Nutr;16: 293-295

1. Zeroing in on molecular
targets
2. Reducing oxidative stress
3. Decreasing DNA damage
4. Inhibit mitochondrial
disturbance
5. Enhancing DNA repair
6. Improve immune functions
7. Blocking inflammation process
8. Optimizing gene expression
9. Improve molecular function
10. Nourish your genes

Courtesy from Barrat Aggra


International Journal of Molecular Sciences 2012, 13(3), 3959-3978

Alternative Medicine Review 2:141153 (

Cancer Letters
Volume 267, Issue 1, 18 August 2008, Pages 133164

European Journal of Clinical Investigations, 27: 908-915.

See nutrigenomic