GENETIC DISORDERS
Ethology of diseases
For any condition, the over all balance of genetic and
environmental determinants can be represented by a
point somewhere within the triangle.
Continuum of Penetrance
There is a Continuum of Penetrance from fully
penetrant conditions, where other genes and
environmental factors have no effect, through to low-
penetrance genes that simply play a small part, along
with other genetic and environmental factors, in
determining a persons susceptibility to a diseases.
Classification of Genetic Disorders
Multifactorial and polygenic
Chromosomal
Low penetrance
Example:
Fragile X chromosome- Characterized by mental
retardation and an inducible cytogenetic abnormality in
the X chromosome.
Non-heritable