Neuroimaging Techniques
Computed Tomography
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Functional Magnetic Resonance Imaging
Diffusion Tensor Imaging
Single Photon Emission Computed Tomography and
Positron Emission Tomography
Reference: Yildirim and Tureli (2015), Schizophrenia: A review of neuroimaging techniques and findings
Neuropathology
CT Scan
lateral and third ventricular enlargement
some reduction in cortical volume
Progressive or static disease - STILL UNCERTAIN
Neuropathology: Reduced Symmetry
Lobes
temporal
frontal
occipital
Originate during fetal life
disruption in brain lateralization during brain neurodevelopment
Neuropathology: Limbic System
Volume shrinkage
Neuronal loss
Medial dorsal nucleus - reduced number of neurons
Total number of neurons, oligodendrocytes and
astrocytes is reduced by 30 to 45 percent
Neuropathology: Basal Ganglia and Cerebellum
2 reasons
odd movements (awkward gait, facial grimacing, and
stereotypies)
movement disorders involving the basal ganglia are the ones
most commonly associated with psychosis
Variable and inconclusive reports about cell loss or reduction of
volume of the globus pallidus and the substantia nigra
Increase in number of D2 receptors in the caudate, putamen and
the nucleus accumbens
Serotonergic system in the basal ganglia
STUDIES INVOLVING NEUROIMAGING IN
SCHIZOPHRENIA
PET Scan