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Arrhytmia In Heart

Failure
Dr. Muhammad Fadil, SpJP
Department of Cardiology and Vascular Medicine
Medicine Faculty of Universitas Andalas/ Dr. M. Djamil Hospital
Padang

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4 SymCARD 2014
Introduction
In heart failure patient population, cardiac arrhythmias
frequently contribute to worsened symptoms, periodic
decompensations, and increased mortality

Arrhythmia recognition and management is an important


aspect of caring for these patients

Chronic heart failure predisposes to both supraventricular


and ventricular arrhythmias
Tedrow U and Stevenson WG. Management of Atrial and Ventricular Arrhythmias in Heart Failure. Marcel Dekker New York. 2005
Atrial Fibrillation (AF)

the most common arrhytmia in


AF heart failure

The potential adverse effects:


Loss of A-V synchrony, rapid or slow
ventricular rate responses
May lead to worsening of symptoms
Atrial fibrillation has been
associated with increased mortality
and more frequent hospitalizations
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Tedrow U and Stevenson WG. Management of Atrial and Ventricular Arrhythmias in Heart Failure. Marcel Dekker New York. 2005
4 SymCARD 2014
Prevalence AF AF is found in 6of patients with
mild heart failure and >40of
patients with advanced heart failure
% Patient with Atrial Fibrilation
0.6

0.5

0.4

0.3

0.2
0.1
0

The incidence of atrial fibrillation in recent heart failure and arrhythmia trials
Thomas SA, et al. AACN Clin Iss 2001; 12(1):156163.
Mechanism of AF in HF

January Ct, et al. Circulation;2015:129


ECG in Atrial Fibrillation (AF)
Classification and Management AF

The following issues need to be considered in patients


with HF and AF, especially first episode of AF or
paroxysmal AF:
Identification of correctable causes
Identification of potential precipitating factors as this may determine
whether a rhythm-control strategy is preferred to a rate control strategy
Assesment for thromboembolism prophylaxis

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McMurray JJV, et al. European Heart Journal (2012) 33, 17871847 4 SymCARD 2014
Management
1.Rate Controlled

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McMurray JJV, et al. European Heart Journal (2012) 33, 17871847 4 SymCARD 2014
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McMurray JJV, et al. European Heart Journal (2012) 33, 17871847 4 SymCARD 2014
Extreme case
AV node ablation and pacing may be required
CRT may be considered instead of conventional pacing

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McMurray JJV, et al. European Heart Journal (2012) 33, 17871847 4 SymCARD 2014
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McMurray JJV, et al. European Heart Journal (2012) 33, 17871847 4 SymCARD 2014
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McMurray JJV, et al. European Heart Journal (2012) 33, 17871847 4 SymCARD 2014
Management
2.Rhythm Controlled
In patients with Chronic HF, a rhythm-control strategy has not been demonstrated to be
superior to a rate-control strategy in reducing mortality or morbidity
In patient with Acute HF with haemodynamic instability emergency cardioversion

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4 SymCARD 2014
Treatment

Amiodarone the only


antiarrhythmic that should be used
in patient wth systolic HF

Catheter Ablation as a rhythm control


strategy in HF = uncertain
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McMurray JJV, et al. European Heart Journal (2012) 33, 17871847 4 SymCARD 2014
Management
3.Thrombo-embolism Prophylaxis

Most patients with systolic HF will have a risk score consistent with a firm
indication for (score2) or preference for an oral anticoagulant (score=1)
although
bleeding risk must also be considered

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McMurray JJV, et al. European Heart Journal (2012) 33, 17871847 4 SymCARD 2014
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4 SymCARD 2014
Ventricular Arrhytmias and Sudden
Cardiac Death
Sudden cardiac death : 20% to 50% of the mortality in HF

Ventricular arrhythmias are a major etiology, and implantable


defibrillators (ICDs) are warranted for many high-risk patients

Bradyarrhythmias caused 41% of in-hospital unexpected cardiac arrests

Conduction disease associated with heart failure, myocardial ischemia,


antiarrhythmic and beta-adrenergic blocking drugs, and hyperkalemia
are important potential etiologies
th
Tedrow U and Stevenson WG. Management of Atrial and Ventricular Arrhythmias in Heart Failure. Marcel Dekker New York. 2005
4 SymCARD 2014
Prevalence

Tedrow U and Stevenson WG. Management of Atrial and Ventricular Arrhythmias in Heart Failure. Marcel Dekker New York. 2005
Monomorphic Ventricular Tachycardia
Ischemic

Mechanisme of VT
Patients with Ischemic Cardiomyopathy typically have
large areas of infarction. Surviving myocyte bundles
present within the infarction create channels for
conduction set up reentry circuits VT

VT is typically monomorphic, with each QRS complex


resembling the preceding and following QRS complex
Tedrow U and Stevenson WG. Management of Atrial and Ventricular Arrhythmias in Heart Failure. Marcel Dekker New York. 2005
Monomorphic Ventricular Tachycardia
non ischemic

Mechanisme of VT
Patients with non Ischemic Cardiomyopathy who develop
sustained monomorphic VT, most have evidence of large areas
of ventricular scar associated with a reentry circuit

The scar may be a consequence of replacement fibrosis from


the myopathic process itself or due to infarcts from embolism
of left ventricular or atrial thrombus to a coronary artery.
Tedrow U and Stevenson WG. Management of Atrial and Ventricular Arrhythmias in Heart Failure. Marcel Dekker New York. 2005
Polymorphic Ventricular Tachycardia

Associated with QT interval prolongation is referred to as torsades de


pointes. Any cause of QT interval prolongation can cause torsades de Pointes

Mechanisme of VT
Electrophysiological changes that accompany ventricular hypertrophy in
chronic heart failure may increase susceptibility to torsades de pointes

Torsades de pointes is often bradycardia-dependent or pause


dependent, with a characteristic initiating sequence
Tedrow U and Stevenson WG. Management of Atrial and Ventricular Arrhythmias in Heart Failure. Marcel Dekker New York. 2005
th
McMurray JJV, et al. European Heart Journal (2012) 33, 17871847 4 SymCARD 2014
Symptomatic Bradycardia and Atrioventricular Block

Indication for pacing

1. Before implanting a conventional pace


Issues
Issuesspecific
specific maker in a patient with HF-REF, consider
to
toHF
HF whether there is an indication for ICD, CRT-
P or CRT-D
2. Because Right ventricular pacing may
induced dysyncrony and worsen symptoms,
CRT should be considered instead of
conventional pacing in patient with HF-REF
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4 SymCARD 2014
ECG in 3rd degree AV block
Take Home Messages
In the heart failure patient population, cardiac arrhythmias
frequently contribute to worsened symptoms, periodic
decompensations, and increased mortality

Atrial fibrillation and ventricular arrhythmias are common in heart


failure patient
Take Home Messages
Sudden cardiac death risk varies depending on etiology of heart
failure and other clinical features

Arrhythmia management in the heart failure population is complex,


requiring careful integration of varied strategies including medication
and procedures

Treatment of arrhythmia in patient with heart failure will decrease


hospitalization and mortality
Thank You
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4 SymCARD 2014

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