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Next Generation PPI backed with cutting edge
Technology
Pellets are re-
The pellets are circulated inside
Cross-Section coated & fall the spray
outside the spray column
of Micro-pellet column

Uniform
Sugar coating with
Wurster The pellets are
Drug
Technology again accelerated
Barrier by the air
Pellets are
Enteric fluidization &
accelerated by air
Coatin recoated to
fluidization
g ensure uniform
coating

Uniform coating prevents

Gastric release & ensures
intestinal delivery for desired
Median pH>4 Time period (hrs)

4
 A comparison trial of the acid-inhibitory effects of
Nexpro 40mg and pantoprazole 40mg
100%
80%
60%
40%
20%
0%

Esomeprazole
40 mg

Nexpro 40mg once daily was more

effective in controlling acid secretion than
pantoprazole 40mg once daily
 A comparison trial of the acid-inhibitory effects of
Nexpro 40mg and Lansoprazole 30mg.
100%

80%

60%
Nexpro 40mg
40%
lansoprazole 30mg
20%

0%
Intragastric PH > 4 for 12 hours

Acid control with Nexpro 40mg was superior to

that with lansoprazole 30mg once daily
 A comparison of the acid-inhibitory effects of
Esomeprazole and Pantoprazole.

Esomeprazole provides acid-inhibition faster than and superior to

pantoprazole after single and repeated administration.
1. Aliment Pharmacol Ther. 2010 Jan;31(1):150-9.
 Omeprazole vs. Esomeprazole - GERD

Nexpro produces greater and more sustained

acid suppression as compared to omeprazole
Nature Reviews Drug Discovery 2, 132-139 (February 2003) 8
 Esomeprazole for moderate to severe night time
heartburn
and gastroesophageal reflux disease-related sleep
disturbances. % Nighttime Heartburn Relief
40%

30%

20%
34.30%

10%

10.40%

0%
Esomeprazole Placebo

Nexpro is effective for patients with moderate to severe

night time heart burn & in GERD related sleep disturbance .
Nexpro 20mg improves heartburn symptoms , sleep quality

1. Aliment Pharmacol Ther. 2010 Apr 29.

 Gastric acid suppression in symptomatic GERD-
comparator study of Esomeprazole,
Lansoprazole, and Pantoprazole.
Esomeprazole suppressed intragastric acid (pH >4.0)
significantly longer over 24 h (primary end point)
compared with Lansoprazole and pantoprazole
(P<0.0001)
Proximal gastric acid (pH >4.0) significantly longer
over 24 h compared with Lansoprazole (P<0.05) and
pantoprazole (P<0.0001).
Esomeprazole was more effective than
Lansoprazole and pantoprazole in suppressing
gastric acidity at both intragastric distal and
proximal (area of the acid pocket) sites in GERD.

1. Aliment Pharmacol Ther. 2010 Apr 23.

 The LAVENDER study : Multinational, double-blind, randomized, placebo-
controlled, prospective study ofesomeprazole in the prevention of recurrent
peptic ulcer in low-dose acetylsalicylic acid users.
Ulcer free rate at 12 week

100%

90%

80%
Esmeprazole 20mg Placebo

DailyEsomeprazole20 mg is efficacious and well tolerated

in reducing the recurrence of peptic ulcer in East-Asian
patients with a history of ulcers who are taking low-dose
ASA for cardiovascular protection. 1. Gut.2013 Dec 10.
 Dosage and Administration :
Indication Dose (mg) Duration
Healing of erosive 20-40 4-8 weeks
oesophagitis
Symptomatic relief 20 4 weeks
of GERD
To prevent relapse 20 Once daily for
of GERD upto 6months
For eradication of 40 mg Once daily for
H.pylori infection 10 days
Note: Esomeprazole should be taken at least one hour before meals.