the world. In the U.S.

, dementia affects
1 in 8 people over the age of 65 and nearly
1 in 2 people over the age of 85. Worldwide
there

are an estimated 30
million
people with
dementia. By
2050, the
number
will rise to over
When can the
world finally forget
about Alzheimers?
Aadya Sharma
Period 2
Research Question
Can the bioavailability of Curcumin as a
treatment for Alzheimers be improved
using Focused Ultrasound Technique
(FUS) as a delivery method?
Alzheimers and its Theories
A neuronal degenerative disease

6th leading cause of death

Neurofibrillary tangles

Beta amyloid theory - protein plaques in the brain

may kill neurons

Blood vessel theory - defective blood supply to the

brain
Treatments on Trial
FUS (Focused Ultrasound) - could temporarily open
the BBB & activate glial cells

J147 - curcumin compound, a drug orally

administered to rats that promoted formation of
BDNF. Not yet tested on humans.

Telomere lengthening - could help reverse ageing

process of glial cells

Coconut oil - provides a different energy source for

Freaky Fun Facts

Education can lower your risk

AD drug candidates have a Named after Dr. Alois

99.6% Alzheimer who first observed
failure rate. Only 1 out of 244 AD in 1906
compounds tested was Linked with a loss of sense of
approved
Down Syndrome smell
is a predisposition.
Glial cells make up 90% of the
Almost all patients die of brain; neurons only 10%
pneumonia
Experimenting and Project
Meta-Analysis - does not require conducting an
authentic experiment

Quasi-Experimentation

If not find a treatment, find a way that does

not work

Prepare a documentary to present my findings

Everyone with
a brain is at
risk for
Alzheimers
 Independent
Research
Do you want to learn what you want for once? Is it your hearts desire to rest on a sofa
and chillax in class?
Do you want to have fun and lead your education while learning essential researching,
oral presentation, and writing skills and working your butt off for your project?
Well then, Independent Research is the perfect class for you!

9th-12th
Weekly Reading Reports & bi-weekly Objective Journals
Develop key skills for life
Research Devt., Process & Analysis, and Communication
Support each other and build friendships
Work with professionals on a topic that interests you
Self-paced, Independent, Fun!
*Room 100, Ms. Bakhru, 2nd 3rd & 4th Periods*
 Intern/Mentor
Do you want to learn what you want for once?
Is it your hearts desire to interact in the real world and gain hands on experience in
your field of study/interest?
Do you also want to work your butt off for your own project?
Well then, Intern/Mentor is the perfect program for you!

11th- 12th
Work with professional(s) in your field of study
Develop key life skills
Research Devt., Process & Analysis, and Communication
Go to an internship/mentor every day during school (looks great on a rsum)
Learn with hands on experience
Have Fun!
*Room 100, Ms. Bakhru, & Out of School*
 Sources
"Home." Focused Ultrasound Foundation. N.p., n.d. Web. 04 Dec. 2016.
<http://www.fusfoundation.org/diseases-and-conditions/brain-disorders/alzheimer-s-disease>
"A Brief Olfactory Test for Alzheimer's Disease - Journal ..." N.p., n.d. Web. 4 Dec. 2016.
<http://www.jns-journal.com/article/S0022-510X(13)00311-0/abstract>
"The Root of Thought: What Do Glial Cells Do?" Scientific American. N.p., 2009. Web. 04 Dec. 2016.
<https://www.scientificamerican.com/article/the-root-of-thought-what/>
"Alzheimer's & Dementia Causes, Risk Factors | Research Center| Alzheimer's Association." Alzheimer's Association. N.p., n.d. Web. 04
Dec. 2016.
<http://www.alz.org/>
"Reversing Alzheimer's by Lengthening Telomeres - H Media." H Media. N.p., 2016. Web. 04 Dec. 2016.
<http://hplusmagazine.com/2015/10/08/reversing-alzheimers-by-lengthening-telomeres/>
Jordo, Jessica F., Emmanuel Thvenot, Kelly Markham-Coultes, Tiffany Scarcelli, Ying-Qi Weng, Kristiana Xhima, Meaghan OReilly, Yuexi
Huang, JoAnne McLaurin, Kullervo Hynynen, and Isabelle Aubert. "Amyloid- Plaque Reduction, Endogenous Antibody Delivery and
Glial Activation by Brain-targeted, Transcranial Focused Ultrasound." Experimental Neurology. U.S. National Library of Medicine, 2013.
Web. 04 Dec. 2016.
<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000699/>
Monte, Suzanne M. De La, and Jack R. Wands. "Alzheimer's Disease Is Type 3 DiabetesEvidence Reviewed." Journal of Diabetes
Science and Technology (Online). Diabetes Technology Society, 2008. Web. 04 Dec. 2016.
<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769828/>
Oakland Mills High School. N.p., n.d. Web. 04 Dec. 2016
<http://omhs.hcpss.org>
Stevens, Michael. Alzheimers and the Brain Online video. Youtube. Youtube, July 22, 2016. Web. Oct 23, 2016.
"Alzheimer's Drug Candidate May Be First to Prevent Disease Progression - Salk Institute for Biological Studies." Salk Institute for Biological
Studies. N.p., n.d. Web. 29 Nov. 2016.
Turkington, Carol. The Encyclopedia of Alzheimer's Disease. New York: Facts On File, 2003. Print.