-Direct invasion of vascular walls by infectious pathogens
-Infections can indirectly induce a non-infectious vasculitis -Eg. generate immune-complexes/ triger cross-reactivity
-Physical & Chemical injury (irradiation, mechanical
trauma, toxin etc)
**Important to differentiate whether it is infectious or non-infectious cause as
Rx. is different. ** Non-infectious v asculitis 1. Immune complex deposition 2. ANCA antibodies 3. Anti-endothelial cell Ab Non-infectious v asculitis 1. Immune-Complex Assoc. Vasculitis -Secondary to drug hypersensitivity -Ab directed against drug-modified protein/ foreign molecules >> immune complexes formation -C/f frequently seen in skin -Drugs bind to serum protein (eg.penicillin) -Drugs themselves as foreign protein (eg. streptokinase) -** discontinuation of drug lead to resolution
-Secondary to viral infection
-Ab to viral proteins >> immune complexes formed & found in serum & vascular lesion -Eg. Polyarteritis nodosa Non-infectious vasculitis 2. ANCA (Anti-neutrophil Cytoplasmic Ab) -Presence of circulating Ab (ANCA) react with neutrophil cytoplasmic Ag